Percutaneous Treatment of Lumbar Herniated Disk

Fabris, G.; Tommasini, G.; Lavaroni, A.; Biasizzo, E.; Petralia, Benedetto; Aprile, I.; Iaiza, F.; Colle, M.; D’Agostini, Serena; Dolso, Pierluigi; Nardi, F. De

doi:10.1177/197140099701000506

Cited by 21 publications

(11 citation statements)

References 7 publications

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“…Of the 34 patients with satisfactory outcome 29 requested a second cycle of treatment and of the 50 patients who failed to benefit from treatment 22 opted for a new cycle of O 2 -O 3 infiltrations. O 2 -O 3 administration proved an effective treatment for root pain caused by spondylolysis thanks to its well-known pain relieving properties [7,8,16] (Fig. 4).…”

Section: Discussionmentioning

confidence: 98%

Oxygen–Ozone Therapy for Degenerative Spine Disease in the Elderly: A Prospective Study

Bonetti

Fontana

Martinelli

et al. 2010

Acta Neurochirurgica Supplementum

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We describe our experience of oxygen-ozone therapy to treat degenerative spine disease in the elderly. From April 2004 to March 2008 we selected 129 patients with CT and/or MR evidence of spondyloarthrosis and disc degeneration of the lumbar spine. All patients enrolled in the study had contraindications to the administration of commonly used analgesic and anti-inflammatory drugs.Oxygen-ozone therapy was given by CT-guided intraforaminal injection as the first treatment followed by 4 weekly paralumbar infiltrations on an outpatient basis. The full treatment lasted a month. Clinical outcome was assessed 3 months and 1 year after treatment. The good results obtained indicate that oxygen-ozone therapy is an ideal treatment with no side-effects in elderly patients with degenerative spine disease.

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Section: Discussionmentioning

confidence: 98%

Oxygen–Ozone Therapy for Degenerative Spine Disease in the Elderly: A Prospective Study

Bonetti

Fontana

Martinelli

et al. 2010

Acta Neurochirurgica Supplementum

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“…Since 1956, when Thomas and later Smith 18,19 experimented chymopapain on humans, many authors hace tried to treat sciatica and low back pain with percutaneous procedures to avoid surgery 4,8,15 . Many others drugs were tested to obtain better results with low cost and fewer side effects (Discase, Lekopain, Chymodiactin and Collagenase).…”

Section: Discussionmentioning

confidence: 99%

Percutaneous Treatment of Herniated Lumbar Disc by Intradiscal Oxygen-Ozone Injection

Muto

Avella

1998

Interv Neuroradiol

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We report our experience of treating lumbar herniated disc by intradiscal injection of an oxygen-ozone mixture. Ozone (03, MW = 48) is a triatomic molecule, having antiviral, disinfectant and antiseptic properties. Several mechanisms of action have been proposed to explain the efficacy of the treatment: analgesic action; anti-inflammatory action; oxidant action on the proteoglycan in the nucleus pulposus. We treated 93 patients (50 women, 43 men) aged from 24 to 45 yrs (average age 38 yrs) from June 1996 to April 1998. All patients presented sciatica and/or low back pain, lasting two or more months; patients had in the mean time received both medical and physical therapy with mild or no benefit. Diagnostic tests in all patients included plain film x-ray, CT and/or MR at the level of the lumbar spine disclasing a herniated or protruded disc with nerve root or thecal sac compression. We divided patients to be treated in to two groups: the first one group included 35 patients already selected for surgery who presented herniated or protruded disc with radicular pain with associated neurological deficit (hypoesthesia and partial loss of reflex). Those patients had already had medical and physical therapy for two or more months and agreed to try the percutaneous treatment before surgery. CT or MR in this group demonstrated the presence of intraforaminal, extra or sub-ligamentary and sequestrated herniated disc. The second group included 58 patients with radicular pain but without neurological deficit; patients in this group had received medical and/or physical therapy for two or more months and CT showed the presence of a small subligamentary herniated or protruded disc. We considered the results according to the modified MacNab method. In the first group we had “failure” in all patients; in seven cases the symptoms improved for one month, but recurred later on. In the second group 45 patients had “success” showing complete clinical recovery within five to six days after treatment, all remained without symptoms up to six months or more of follow-up. The remaining 13 patients presented the same symptoms again within three months after a temporary clinical recovery. The goal of this study was to present this new technique that can also be compared with a previous study of different percutaneous treatment. Clinical and neuroradiological indications and the contraindications are well known, and must be followed to achieve good results and avoid complications.

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“…The paravertebral intramuscular treatment produces pain relief in the majority of patients, together with decongestion, reabsorption of oedema and increased mobility. This has triggered the idea of injecting the oxygen-ozone mixture in the intervertebral disc and the conjugation foramen in order to obtain a powerful e¤ect directly on the pathological mechanism [1,7,9]. Recently application of these gases has been used also in cervical disc pathology.…”

Section: Introductionmentioning

confidence: 99%

“…Studies on pain originating from this pathology show that it may be due to biochemical mechanisms of acid intoxication of the nerve, which may be somehow independent from the mechanical problem but may result either from an autoimmune reaction, producing a chronic inflammatory response engendering an acid environment, or a situation of ischemia [10]. These problems may be solved by biochemical treatment, reducing the need for surgical intervention [1][2][3]7]. On the other hand, the mechanism of disc shrinkage and elimination of herniated fragments have carefully been studied and the development of an autoimmune response against a ''non-self '' material, leading to a chronic inflammatory reaction has been demonstrated [6].…”

Section: Introductionmentioning

confidence: 99%

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Intradiscal injection of oxygen-ozone gas mixture for the treatment of cervical disc herniations

Alexandre¹,

Corò²,

Azuelos³

et al.

Acta Neurochirurgica

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SummaryFor disc herniations the use of open surgical approaches is reduced since new percutaneous methods allowing shrinkage of the disc and improvement of the radicular function are gaining interest. Studies on the spontaneous disappearance of disc fragments have demonstrated autoimmune responses with a chronic inflammatory reaction. Also radicular pain has been shown to be mostly due to biochemical mechanisms [10]. Researchers in di¤erent fields surprisingly noticed that a brief, calculated, oxidative stress by ozone administration may correct a persistent imbalance due to excessive, chronic oxidative injury [4]. Oxygen-ozone gas injection in painful patients has a dramatic e¤ect on clinical symptoms. On these bases the intradiscal injection of oxygen-ozone gas has been conceived [1,7,9]. We report the treatment on a series of patients a¤ected by cervical disc pathology, treated by intradiscal injection of oxygen-ozone gas mixture. The e¤ects both on pain and on radicular dysfunction are impressive. The morphological e¤ect of the treatment was also evaluated by pathological examination.

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Percutaneous Treatment of Lumbar Herniated Disk

Cited by 21 publications

References 7 publications

Oxygen–Ozone Therapy for Degenerative Spine Disease in the Elderly: A Prospective Study

Oxygen–Ozone Therapy for Degenerative Spine Disease in the Elderly: A Prospective Study

Percutaneous Treatment of Herniated Lumbar Disc by Intradiscal Oxygen-Ozone Injection

Intradiscal injection of oxygen-ozone gas mixture for the treatment of cervical disc herniations

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