Percutaneous Transhepatic Catheterization of the Portal Venous System

Burcharth, F

doi:10.1007/978-4-431-68361-2_10

Cited by 6 publications

(4 citation statements)

References 38 publications

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“…For this study, eligible patients had to meet the following entry criteria: (a) no previous treatment for esophagogastric varices, (b) no previous surgery on the stomach, (c) no hepatoma, (d) presence of esophageal varices, (e) no contraindication of percutaneous transhepatic portography (uncontrolled ascites, prothrombin time index < 40%, thrombocyte count < 40,000/~1) (17). Therefore this study included 56 cirrhotic patients with portal hypertension (35 men and 21 women) 36 to 76 yr old (mean ?…”

Section: Patientsmentioning

confidence: 99%

Portal and gastric mucosal hemodynamics in cirrhotic patients with portal-hypertensive gastropathy

et al. 1994

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Controversy exists as to the nature of gastric perfusion in portal-hypertensive gastropathy. To investigate portal hemodynamics and gastric mucosal perfusion in cirrhotic patients with and without portal-hypertensive gastropathy, we subjected 56 cirrhotic patients with portal hypertension to portal vein catheterization, pneumatic pressure sensor technique, duplex sonography and laser Doppler flowmetry. Thirteen patients had portal-hypertensive gastropathy: In 10 it was mild, and in 3 it was severe. The presence of portal-hypertensive gastropathy seemed to be independent of age, sex, cause of cirrhosis or grade of esophageal varices. Portal venous pressure, esophageal variceal pressure, portal venous flow and congestion index in patients with portal-hypertensive gastropathy were not significantly different from the values in those without portal-hypertensive gastropathy. However, portal-variceal pressure gradient (subtracting esophageal variceal pressure from portal venous pressure) (p < 0.01) and the incidence of palisading-type esophageal varices on portography (p < 0.05) was increased in patients with portal-hypertensive gastropathy significantly more than in those without portal-hypertensive gastropathy. In the fundus, gastric mucosal blood flow was significantly higher in patients with portal-hypertensive gastropathy than in those without portal-hypertensive gastropathy, whereas in the corpus and the antrum the values were not significantly different. We suggest that the mucosa of the upper stomach in patients with portal-hypertensive gastropathy is congestive and highly perfused. The pathogenesis of portal-hypertensive gastropathy may be related to both congestion and hyperemia in the upper stomach.

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Section: Patientsmentioning

confidence: 99%

Portal and gastric mucosal hemodynamics in cirrhotic patients with portal-hypertensive gastropathy

et al. 1994

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“…A total of 24 h post-surgery, stable black thrombi with hardened vascular walls and venous stenosis were formed, supporting the validity of the modeling method. Additionally, since the portal vein is relatively thin, and has confluent intestinal and splenic branches, puncture catheterization is difficult to perform (25). In the current study, B-scan ultrasonography was used to evaluate thrombus formation.…”

Section: Discussionmentioning

confidence: 99%

The inhibitory role of recombinant P‑selectin glycoprotein ligand immunoglobulin G on portal vein thrombosis based on a novel rat model

et al. 2019

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The current study aimed to reveal a novel method for constructing a portal vein thrombosis (PVT) model in rats and to evaluate the inhibitory role of recombinant P-selectin glycoprotein ligand immunoglobulin G (rPSGL-Ig) on the formation of PVT. The PVT model was constructed in rats through intermittent portal vein obstruction (IPVO) combined with endangium destruction. A total of 4 mg/kg rPSGL-Ig was intraperitoneally pre-injected into rats 1 h prior to model construction. Changes in the thrombus size and vessel diameter were observed by B-scan ultrasonography. Histopathological changes in the portal vein, central hepatic vein and vasa intestini tenuis were observed using hematoxylin and eosin staining. Additionally, histopathological changes in the portal vein were observed by transmission electron microscopy. A total of 8 mg/kg rPSGL-Ig or 2×10 4 U/kg urokinase were used to compare the thrombolytic effects and thrombus sizes. The PVT model was successfully constructed in rats, and exhibited a significantly greater thrombus size and vessel diameter compared with the control group (P<0.05). Intervention with rPSGL-Ig significantly inhibited the formation of PVT, and resulted in a significantly lower thrombus size and vessel diameter compared with the model group (P<0.05). Additionally, histopathological changes in the portal vein, central hepatic vein and vasa intestini tenuis in PVT rats were considerably reversed following the intervention with rPSGL-Ig. rPSGL-Ig demonstrated a lower thrombolytic effect compared with that of URO. IPVO combined with endangium destruction effectively constructed a PVT model in rats. rPSGL-Ig effectively prevented PVT in rats. rPSGL-Ig may be used in future studies for the treatment of patients with PVT.

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“…30,31 Percutaneous transhepatic portography was done for 38 patients, excluding any subjects with contraindications such as a prothrombin level below 40% of normal, thrombocyte counts below 40.000/mm 3 , and ascites. 32 At that time, the portal venous pressure (PVP) was measured directly, using a transducer with a catheter placed in the portal vein. Portal vascular resistance (PVR) was calculated using the formula PVR = PVP/PVF (mmH2O/mL/ min).…”

Section: Study 2: Mechanisms Of the Changes In Hv Waveform In Cirrhotmentioning

confidence: 99%

Abnormality of the hepatic vein waveforms in cirrhotic patients with portal hypertension and its prognostic implications

Kawanaka¹,

Kinjo²,

Anegawa³

et al. 2008

J of Gastro and Hepatol

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Percutaneous Transhepatic Catheterization of the Portal Venous System

Cited by 6 publications

References 38 publications

Portal and gastric mucosal hemodynamics in cirrhotic patients with portal-hypertensive gastropathy

Portal and gastric mucosal hemodynamics in cirrhotic patients with portal-hypertensive gastropathy

The inhibitory role of recombinant P‑selectin glycoprotein ligand immunoglobulin G on portal vein thrombosis based on a novel rat model

Abnormality of the hepatic vein waveforms in cirrhotic patients with portal hypertension and its prognostic implications

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