Percutaneous nephrolithotomy and modern aspects of complications and antibiotic treatment

Wagenius, Magnus; Borglin, Jasmine; Popiołek, Marcin; Forsvall, Andreas; Stranne, Johan; Linder, Adam

doi:10.1080/21681805.2020.1740316

Cited by 9 publications

(8 citation statements)

References 24 publications

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“…Interestingly, patients with verifiable bacteria in kidney stones displayed a prolonged LOS due to different post-operative complications. Similarly, Wagenius et al demonstrated, that patients with positive stone cultures harbor a greater risk for post-operative urosepsis, than those with just positive urine culture [ 27 ]. So the evidence of pathogens in the kidney is a tremendous risk for infectious complications.…”

Section: Discussionmentioning

confidence: 99%

The microbiome of kidney stones and urine of patients with nephrolithiasis

et al. 2023

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The incidence of nephrolithiasis is rising worldwide. Although it is a multifactorial disease, lifestyle plays a major role in its etiology. Another considerable factor could be an aberrant microbiome. In our observational single-center study, we aimed to investigate the composition of bacteria in kidney stones and urine focusing on patients with features of metabolic syndrome. Catheterized urine and kidney stones were collected prospectively from 100 consecutive patients undergoing endoscopic nephrolithotomy between 2020 and 2021 at our clinic. Microbiome composition was analyzed via 16S rRNA gene amplicon sequencing. Detection of bacteria was successful in 24% of the analyzed kidney stones. These patients had a prolonged length of stay compared to patients without verifiable bacteria in their stones (2.9 vs 1.5 days). Patients with features of metabolic syndrome were characterized by kidney stones colonized with classical gastrointestinal bacteria and displayed a significant enrichment of Enterococcaceae and Enterobacteriaceae. Stones of patients without features of metabolic syndrome characterized by Ureaplasma and Staphylococcaceae. Patients with bacteria in their kidney stones exhibit a longer length of stay, possibly due to more complex care. Patients presenting with features of metabolic syndrome displayed a distinct stone microbiome compared to metabolically fit patients. Understanding the role of bacteria in stone formation could enable targeted therapy, prevention of post-operative complications and new therapeutic strategies.

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Section: Discussionmentioning

confidence: 99%

The microbiome of kidney stones and urine of patients with nephrolithiasis

et al. 2023

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“…Seeking biomarkers that can be used to predict the occurrence of urosepsis may contribute to the early diagnosis of urosepsis and improve the prognosis of septic patients. Based on previous studies, we supposed that serum histone H3 is the biomarker Since the revision of the international consensus of Sepsis-3, the diagnosis rate of sepsis has greatly improved, revealing sepsis to be among the most serious complications in patients after PCNL, with an incidence ranging from 3.5 to 35.05% [20][21][22][23][24]. The release of kidney stone-colonizing bacteria and other bacterial endotoxins during surgery into the circulation system coupled with elevated renal pelvis pressure is believed to be the main cause of postoperative infection and urosepsis [25,26].…”

Section: Discussionmentioning

confidence: 99%

Early Changes and Predictive Value of Serum Histone H3 Concentration in Urosepsis: A Prospective Observational Study

et al. 2022

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“…Similarly, Wagenius et al demonstrated, that patients with positive stone cultures harbor a greater risk for postoperative urosepsis, than those with just positive urine culture. [27] So the evidence of pathogens in the kidney is a tremendous risk for infectious complications.…”

Section: Discussionmentioning

confidence: 99%

The Microbiome of Kidney Stones and Urine of Patients with Nephrolithiasis

Lemberger

Pjevac

Hausmann

et al. 2022

Preprint

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Purpose: The incidence of nephrolithiasis is rising worldwide. Although it is a multifactorial disease, lifestyle plays a major role in its etiology. Another considerable factor could be an aberrant microbiome. In our observational single-center study, we aimed to investigate the composition of bacteria in kidney stones and urine focusing on patients with features of metabolic syndrome. Material and Methods: Catheterized urine and kidney stones were collected prospectively from 100 consecutive patients undergoing endoscopic nephrolithotomy between 2020 and 2021 at our clinic. Microbiome composition was analyzed via 16S rRNA gene amplicon sequencing. Results: Detection of bacteria was successful in 24% of the analyzed kidney stones. These patients had a prolonged length of stay compared to patients without verifiable bacteria in their stones (2.9 vs 1.5 days). Patients with features of metabolic syndrome were characterized by kidney stones colonized with classical gastrointestinal bacteria and displayed a significant enrichment of Enterococcacea and Enterobacteriaceae. Stones of patients without features of metabolic syndrome are characterized byUreaplasma and Staphylococcaceae. Conclusion: Patients with bacteria in their kidney stones exhibit a longer length of stay, possibly due to more complex care. Patients presenting with features of metabolic syndrome displayed a distinct stone microbiome compared to metabolically fit patients. Understanding the role of bacteria in stone formation could enable targeted therapy, prevention of postoperative complications and new therapeutic strategies.

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Percutaneous nephrolithotomy and modern aspects of complications and antibiotic treatment

Cited by 9 publications

References 24 publications

The microbiome of kidney stones and urine of patients with nephrolithiasis

The microbiome of kidney stones and urine of patients with nephrolithiasis

Early Changes and Predictive Value of Serum Histone H3 Concentration in Urosepsis: A Prospective Observational Study

The Microbiome of Kidney Stones and Urine of Patients with Nephrolithiasis

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