Percutaneous malathion absorption by anuran skin in flow-through diffusion cells

Willens, Scott; Stoskopf, Michael K.; Baynes, Ronald E.; Lewbart, Gregory A.; Taylor, Sharon K.; Kennedy‐Stoskopf, Suzanne

doi:10.1016/j.etap.2006.04.010

Cited by 28 publications

(28 citation statements)

References 27 publications

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“…Furthermore, thyroid hormone also plays an essential role in tadpole skeletal development [20]. Amphibians are regarded as a good indicator for aquatic environmental changes because of their gill and skin permeability and vulnerability [21,22]. It is believed that Cd pollution is one of the main threats to amphibian population decline worldwide [23].…”

Section: Introductionmentioning

confidence: 99%

Effects of chronic cadmium exposure on metamorphosis, skeletal development, and thyroid endocrine disruption in Chinese toad Bufo gargarizans tadpoles

Sun

Wang

et al. 2017

Enviro Toxic and Chemistry

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The present study examined the effects of chronic cadmium (Cd) exposure on metamorphosis, body size, thyroid gland, and skeletal development of Chinese toad (Bufo gargarizans) tadpoles. Tadpoles were exposed to Cd concentrations at 0, 5, 10, 50, 100, and 500 μg/L from Gosner stages 26 to 46 of completion of metamorphosis. Our results showed that 100 and 500 μg/L of Cd concentrations increased mortality and decelerated metamorphosis rate. In addition, significant body size reduction at Gosner stage 42 was observed at 100 and 500 μg/L of Cd treatments (p < 0.01). Average body length and hind-limb length were significantly decreased in the 500 μg/L of Cd group (p < 0.05) but body mass was not significantly different at Gosner stage 46. Moreover, bone formation was delayed in high Cd concentration treatments (50, 100, and 500 μg/L) at both Gosner stage 42 and 46. Histopathological changes of the thyroid gland showed that follicular cell hyperplasia and malformation were induced by high Cd concentrations (50, 100, and 500 μg/L). Furthermore, real-time polymerase chain reaction analysis suggested that the larvae exposed to high-dose Cd exhibited a significant decrease in deiodinase (Dio2) and thyroid hormone receptor (TRβ) mRNA levels at Gosner stage 42 and 46. Our investigation indicated that high-dose Cd caused metamorphic deceleration, body size reduction, and delayed skeletal development through disrupting the thyroid system in B. gargarizans larvae. Environ Toxicol Chem 2018;37:213-223. © 2017 SETAC.

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Section: Introductionmentioning

confidence: 99%

Effects of chronic cadmium exposure on metamorphosis, skeletal development, and thyroid endocrine disruption in Chinese toad Bufo gargarizans tadpoles

Sun

Wang

et al. 2017

Enviro Toxic and Chemistry

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“…There is an increased concern about the sublethal effects of organophosphorous compounds on human and animal health (Jaga and Dharmani, 2003). Integration of human and wildlife health research and modeling are necessary to assess the potential ecological risks of these pesticides because certain wildlife species can show effects that are more subtle or take longer to manifest in humans (Willens et al, 2006). The widespread use of organophosphorous insecticides (due to their low toxicity to humans and low environmental persistence) coupled with the permeability to anuran skin and sensitivity to environmental toxicants make anurans important animal models for studying the impacts of insecticide contamination of the environment (Taylor et al, 1999a,b).…”

Section: Discussionmentioning

confidence: 99%

Effect of mosquito larvicide Abate® on the developmental stages of the Asian common toad, <i>Bufo melanostictus</i>

Harischandra¹,

Karunaratne²,

Rajakaruna

2012

Ceylon J. Sci. (Biol. Sci.)

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Exposure to chemical contaminants has been identified as a key factor causing widespread mortalities and malformations in amphibians world over. We examined the effect of exposure to commonly used mosquito larvicide, Abate ® which has temephos as the active ingredient, on the Asian common toad, Bufo melanostictus, under laboratory conditions. The LC 50 values of 16.56 ppm and 17.03 ppm were obtained when one-day old tadpoles (Gosner stage 21-24) and one-week old tadpoles (Gosner stage 25) were exposed to Abate for two weeks, respectively. Chronic exposure to Abate at effective field concentrations used in mosquito control programmes (WHO recommended doses) had a significant effect on the survival of egg stage (Gosner stages 12-14), and one day old tadpoles but not on one week old tadpoles. Tadpoles exposed to Abate grew larger and had a longer larval period and the difference in the duration of larval period was statistically significant. Exposed tadpoles also developed malformations such as rotation of bones, micromelia of the limb bones, hemimelia of femur, skin webbing in the hind limbs and ectrodactyly. Edemas were also observed in the exposed tadpoles. Exposure to all concentrations of Abate had a significant effect on the survival, growth and development of malformations in the early tadpole stages compared to the control group. The reduction in survival was not significant when older tadpoles of one week post-hatch were exposed, although they developed malformations and their larval period was prolonged significantly compared to the control group. Thus, the study shows that Abate is lethal to the early stages of the Asian common toad but the toxicity decreased as the tadpoles grow older.

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“…The unique position of amphibians at the aquatic/terrestrial interface makes their population health an important marker of ecosystem health. The challenge of understanding the translational impacts of their physiology and ecology, such as their unusual and diverse skin structures that affect absorption kinetics of xenobiotics, is critical to our understanding of human health (Willens et al 2006). The more we learn about the impacts of ecological factors on amphibian health, the better we understand the necessity of managing amphibians in laboratories with utmost care.…”

mentioning

confidence: 99%

The Art of Amphibian Science

Smith¹,

Stoskopf²

2007

ILAR Journal

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Percutaneous malathion absorption by anuran skin in flow-through diffusion cells

Cited by 28 publications

References 27 publications

Effects of chronic cadmium exposure on metamorphosis, skeletal development, and thyroid endocrine disruption in Chinese toad Bufo gargarizans tadpoles

Effects of chronic cadmium exposure on metamorphosis, skeletal development, and thyroid endocrine disruption in Chinese toad Bufo gargarizans tadpoles

Effect of mosquito larvicide Abate® on the developmental stages of the Asian common toad, <i>Bufo melanostictus</i>

The Art of Amphibian Science

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