Percutaneous injection of hemostatic agents for severe blunt hepatic trauma: an experimental study

Tang, Jie; Lv, Faqin; Li, Wenxiu; Zhang, Huiqin; Luo, Yukun; An, Lichun; Li, Tanshi

doi:10.1007/s00330-008-1096-5

Cited by 8 publications

(4 citation statements)

References 22 publications

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“…This method creates excellent haemostasis by directly injecting haemostatic agents under contrast-enhanced ultrasonography (CEUS) guidance into injury sites to stop bleeding [4][5][6]. We designed this animal experiment to explore the effectiveness and safety of this new method to treat blunt splenic trauma.…”

Section: Introductionmentioning

confidence: 98%

Effectiveness and safety of CEUS-guided haemostatic injection for blunt splenic trauma: an animal experiment

Tang

et al. 2010

Radiol med

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The aim of this study was to investigate whether complications occur after haemostatic agents are injected into blunt splenic injuries. After undergoing ultrasound (US), contrast-enhanced US (CEUS) and contrast-enhanced computed tomography (CECT) examinations, dogs with grade III-IV injury received the minimally invasive therapy. After treatment, CEUS was performed to observe changes in the regions treated. In the immediate group, dogs underwent laparotomy 30 min after treatment to observe the haemostatic effect. In the survival group, animals underwent CEUS and CECT examinations to observe the short-term healing outcome and complications at 3, 7, 14, and 21 days after the injection. After undergoing CEUS and CECT examinations, 12 dogs with grade III-IV injury received the minimally invasive therapy. Before injection, CEUS examinations showed anechoic and/or hypoechoic perfusion defects and active bleeding at the injury sites, and CECT showed traumatic lesions as low-density regions without enhancement. After treatment, CEUS demonstrated the disappearance of active bleeding, and hyperechoic spots emerged at the injury sites. Uneven density regions were displayed on CECT. Treated areas were covered by blood clots and glue membrane in the immediate-group animals. Three weeks later, CEUS showed a decrease of hyperechoic spots in the survival group, and the splenic parenchyma enhanced uniformly on CECT. Laparotomy showed that the greater omentum had moved upwards and partly covered the wound in four animals, and the injury sites had completely healed. Histopathological examination showed that fibrous connective tissue covered the splenic capsule and that the haemostatic glue had degraded. No complication occurred, such as delayed splenic haemorrhage, splenic abscesses, splenic pseudoaneurysms, intestinal obstruction or intestinal adhesions. CEUS-guided haemostatic injection is not only effective in stopping active bleeding immediately, but it is also safe in that no complications occurred during the 3 weeks of follow-up. This study indicates that CEUS-guided percutaneous injection may provide a safe, feasible and effective therapy for blunt splenic trauma.

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Section: Introductionmentioning

confidence: 98%

Effectiveness and safety of CEUS-guided haemostatic injection for blunt splenic trauma: an animal experiment

Tang

et al. 2010

Radiol med

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“…Cyanoacrylate was effectively used during the endoscopic ultrasound-guided treatment of fundic varices formed under conditions of portal hypertension 144 . The α-cyanoacrylate-based adhesive, applied to a dog model with severe liver injury, can close wounds and reduce bleeding 145 . Some problems still need to be addressed to increase the application prospects of α-cyanoacrylate-based adhesives.…”

Section: Introductionmentioning

confidence: 99%

Recent advances in the medical applications of hemostatic materials

Yu¹,

Wang²,

Liu³

et al. 2023

Theranostics

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Bleeding caused by trauma or surgery is a serious health problem, and uncontrollable bleeding can result in death. Therefore, developing safe, effective, and convenient hemostatic materials is important. Active hemostatic agents currently used to investigate the field of hemostasis are divided into four broad categories: natural polymers, synthetic polymers, inorganic materials, and metal-containing materials. Hemostatic materials are prepared in various forms for wound care applications based on the active ingredients used. These materials include nanofibers, gels, sponges, and nanoparticles. Hemostatic materials find their applications in the field of wound care, and they are also used for hemostasis during malignant tumor surgery. Prompt and effective hemostasis can reduce the possibility of the spread of tumor cells with blood. This review discusses the outcomes of current research conducted in the field and the problems persisting in the field of developing hemostatic materials. The review also presents a platform for the further development of hemostatic materials. Bleeding caused by trauma or surgery is a serious health problem, and uncontrollable bleeding can result in death. Therefore, developing safe, effective, and convenient hemostatic materials is important. Active hemostatic agents currently used to investigate the field of hemostasis are divided into four broad categories: natural polymers, synthetic polymers, inorganic materials, and metal-containing materials. Hemostatic materials are prepared in various forms for wound care applications based on the active ingredients used. These materials include nanofibers, gels, sponges, and nanoparticles. Hemostatic materials find their applications in the field of wound care, and they are also used for hemostasis during malignant tumor surgery. Prompt and effective hemostasis can reduce the possibility of the spread of tumor cells with blood. This review discusses the outcomes of current research conducted in the field and the problems persisting in the field of developing hemostatic materials. The review also presents a platform for the further development of hemostatic materials.

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“…Pancreatic contusion and laceration (PCL) is classified as a grade I-II injury based on the American Association for the Surgery of Trauma (AAST) organ injury scaling (2), with a conservative strategy being recommended as its primary form of management (3). Ultrasound (US)-guided percutaneous intervention (UGPI) plays an important role in the clinical management of PCL, as it is used for the delivery of local drug therapy and fluid drainage (4)(5)(6)(7)(8). In addition, particular precision in the delivery of UGPI is required in PCL because of the retroperitoneal location of the pancreas.…”

Section: Introductionmentioning

confidence: 99%

CT-US fusion imaging increases the feasibility of early ultrasound-guided percutaneous intervention of local drug therapy in pancreatic contusion and laceration

Feng¹,

Wang²,

Huang³

et al. 2021

Ann Transl Med

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Background: Multimodal fusion imaging (MMFI) was usually used to assist percutaneous procedures for difficult lesions, with most applications occurring with hepatic and prostatic interventions. This paper aimed to evaluate the precision and effectiveness of computed tomography-ultrasound (CT-US) fusion imaging (CUFI)-assisted US-guided percutaneous intervention (UGPI) in early local drug therapy for pancreatic contusion and laceration (PCL).Methods: A total of 12 pigs with PCL were randomly divided into a CUFI-assisted UGPI (MU) group (n=6) and a single UGPI (SU) group (n=6). The MU group underwent CUFI-assisted UGPI of locally applied medical protein glue (1 mL) injection while the SU group received the same therapy using two-dimensional UGPI. The duration and accuracy of each procedure were observed in the 2 groups.Results: In the MU group, the overall time of the procedure for locking the plane was 1.85±0.06 minutes.Less time was spent in the selection of the pathway and puncture site in the MU group compared with the SU group (6.56±0.42 vs. 7.61±0.44 minutes, P<0.01). The duration of puncturing and drug injection was also shorter in the MU group than in the SU group (3.41±0.30 vs. 4.20±0.20 minutes, P<0.01) and the MU group had a higher accuracy of medical protein glue injection than the SU group (100% vs. 50%, P<0.05).Conclusions: CUFI could increase the precision and effectiveness of early UGPI in the delivery of local drug therapy in PCL.

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Percutaneous injection of hemostatic agents for severe blunt hepatic trauma: an experimental study

Cited by 8 publications

References 22 publications

Effectiveness and safety of CEUS-guided haemostatic injection for blunt splenic trauma: an animal experiment

Effectiveness and safety of CEUS-guided haemostatic injection for blunt splenic trauma: an animal experiment

Recent advances in the medical applications of hemostatic materials

CT-US fusion imaging increases the feasibility of early ultrasound-guided percutaneous intervention of local drug therapy in pancreatic contusion and laceration

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