Percutaneous Absorption of Zinc in Acrodermatitis enteropathica

Parra, Cristóbal A.; Smalik, A. V.

doi:10.1159/000250194

Cited by 7 publications

(2 citation statements)

References 7 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Although the stratum corneum is the principle skin barrier, it is uncertain whether zinc penetrated the entire skin layer, since epidermal fragments remained in the specimens. In another study, systemic absorption of zinc was shown in a child with severely diseased skin treated with 25% zinc oxide paste in the diaper area [9]. Since skin diseases arc associated with an increased skin permeability, this could partly account for the observed zinc absorption.…”

Section: Discussionmentioning

confidence: 94%

Percutaneous Absorption of Zinc from Zinc Oxide Applied Topically to Intact Skin in Man

Ågren

1990

Dermatology

View full text Add to dashboard Cite

The penetration of zinc through normal skin treated with a zinc oxide (25%) medicated occlusive dressing was studied.The mean release rate of zinc to the skin was 5 μg/cm²/h. After 48 h of treatment suction blisters were raised by the« Kiistala method. The zinc concentration of the epidermis blister fluid and dermis was increased beneath the zinc dressing compared to control-treated skin. The study shows that zinc permeates intact human skin from topically applied zinc oxide in vivo.

show abstract

Section: Discussionmentioning

confidence: 94%

Percutaneous Absorption of Zinc from Zinc Oxide Applied Topically to Intact Skin in Man

Ågren

1990

Dermatology

View full text Add to dashboard Cite

show abstract

“…It is known that zinc is absorbed transcutaneously [15,19]. Parra and Smalik treated an 8-monthold infant suffering from acrodermatitis enteropathica exclusively with zinc paste (25% zinc oxide) in the anogenital area [30]. This resulted in complete normalization of the skin condition and laboratory values.…”

Section: Discussionmentioning

confidence: 99%