Percutaneous Absorption of Corticosteroids: Age, Site, and Skin-Sectioning Influences on Rates of Permeation of Hairless Mouse Skin by Hydrocortisone

Behl, Charangit R.; Flynn, Gordon L.; Linn, Edwards E.; Smith, Ward M.

doi:10.1002/jps.2600730925

Cited by 32 publications

(7 citation statements)

References 16 publications

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“…Since a phenomenon of increasing permeability as a function of time was observed for urea, thiourea, glycerol, glucose, water and methanol by Ackermann (1983) and for hydrocortisone and hydrocortisone 21-n-alkyl esters (Smith, 1982 andBehl et al, 1984), one should be cautious about drawing extensive conclusions on the ether-water partitioning/percutaneous absorption relationships while there is uncertainty about the permeability coefficient that should be used.…”

Section: Resultsmentioning

confidence: 99%

Ether-water partitioning and permeability through nude mouse skin in vitro. II. Hydrocortisone 21-n-alkyl esters, alkanols and hydrophilic compounds

Ackermann

Flynn

Smith

1987

International Journal of Pharmaceutics

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The permeability coefficients obtained by means of an infinite dose diffusion cell system with nude mouse skin in vitro were compared to the ether-water partition coefficients of the following compounds: glucose, urea, glycerol, thiourea, alkanols (methanol to octanol), hydrocortisone and hydrocortisone 21-n-alkyl esters (-acetate to-heptanoate). The permeability coefficients ranged from 1.0 x 10-6 cm/h (glucose) to 0.34 cm/h (hydrocortisone-21-heptanoate). The ether-water partition coefficients ranged between 9.0 X 10-6 (glucose) and 1.4 x 104 (hydrocortisone-21-heptanoate). No general pattern emerged when the permeability coefficient is taken as a function of the ether-water partition coefficient for these compounds. Therefore the skin can not be regarded as a simple lipoidal barrier.

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Section: Resultsmentioning

confidence: 99%

Ether-water partitioning and permeability through nude mouse skin in vitro. II. Hydrocortisone 21-n-alkyl esters, alkanols and hydrophilic compounds

Ackermann

Flynn

Smith

1987

International Journal of Pharmaceutics

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“…Lambert et al50 studied the effects of skin hydration on the skin permeabilities of various hydrophobic and hydrophilic permeants across hairless mouse skin and reported that skin hydration leads to enhancement of the skin porous pathway within the hairless mouse skin, but does not significantly alter the skin lipid pathway of the excised hairless mouse skin. Previously, the transport properties of hairless mouse skin have been studied extensively, and its hydration tendency has been well documented 49,51,52. Although excised pig skin has been recognized as a better skin model of human skin than hairless mouse skin for in vitro percutaneous absorption studies based on its morphological and functional characteristics,45,46 the effects of skin hydration on its transport properties have not been investigated systematically in the past.…”

Section: Discussionmentioning

confidence: 99%

Prediction of steady‐state skin permeabilities of polar and nonpolar permeants across excised pig skin based on measurements of transient diffusion: Characterization of hydration effects on the skin porous pathway

Tang

Blankschtein

Langer

2002

Journal of Pharmaceutical Sciences

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“…In another study (with SKH-hr -1 mice) on percutaneous absorption of corticosteroids, it was suggested that to some permeating species, intact human and hairless integuments offered quantitatively different mass transfer resistance, with human skin being at least one logarithmic order less permeable [30]. A study on the permeation of hydrocortisone in human and hairless mouse skin (SKH-hr -1 ), and the effects of an enhancer revealed that the peak permeability in human epidermis was an order of magnitude smaller than for mouse skin [31].…”

Section: Ooooooooooooooooomentioning

confidence: 99%

Relevance of Hairless Mouse as an Experimental Model of Percutaneous Penetration in Man

Simon

Maibach

1998

Skin Pharmacol Physiol

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Since their first description in 1850, hairless mice have been widely used in scientific research. One major aspect of their use is skin pharmacology in general and skin penetration studies in particular. The term ‘hairless mouse’ does not distinguish a unique animal: it is a collective, descriptive name for a large group of different strains of various genetic origin. It is therefore important to precisely define the strain of mice used in a study. The available information on comparative penetration studies in man and in hairless mouse is sometimes contradictory. Some compounds will penetrate in an almost similar manner, whereas others differ in at least one logarithmic order, the human skin being the less permeable. Skin permeability is influenced, among others, by the physicochemical qualities of the compound under investigation. To obtain a clearer view on the suitability of the hairless mouse model in skin penetration studies, it should be useful to study this issue prospectively in a systematic fashion.

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Percutaneous Absorption of Corticosteroids: Age, Site, and Skin-Sectioning Influences on Rates of Permeation of Hairless Mouse Skin by Hydrocortisone

Cited by 32 publications

References 16 publications

Ether-water partitioning and permeability through nude mouse skin in vitro. II. Hydrocortisone 21-n-alkyl esters, alkanols and hydrophilic compounds

Ether-water partitioning and permeability through nude mouse skin in vitro. II. Hydrocortisone 21-n-alkyl esters, alkanols and hydrophilic compounds

Prediction of steady‐state skin permeabilities of polar and nonpolar permeants across excised pig skin based on measurements of transient diffusion: Characterization of hydration effects on the skin porous pathway

Relevance of Hairless Mouse as an Experimental Model of Percutaneous Penetration in Man

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