Prediction of steady‐state skin permeabilities of polar and nonpolar permeants across excised pig skin based on measurements of transient diffusion: Characterization of hydration effects on the skin porous pathway

Tang, Hua; Blankschtein, Daniel; Langer, Robert

doi:10.1002/jps.10177

Cited by 41 publications

(25 citation statements)

References 57 publications

(88 reference statements)

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“…The device and measurement interface are mechanically imperceptible to the user, and therefore compatible for evaluation on any part of the body, in a manner that obviates the need for pressure sensing and offers potential for use in continuous, long-term recordings. The results outlined in the following extend our previously reported platforms for this purpose by (1) integrating both thermal and electrical characterization capabilities into a single measurement system, (2) introducing simple algorithms for extracting a full complement of intrinsic thermal and electrical properties from the measurement data, with good quantitative correspondence to simple models of the skin, and (3) applying the technology in a comprehensive clinical trial, with 20 patients and a variety of skin stimuli, for validation and comparison against clinical standard tools, that is, corneometers. The findings establish the design considerations, the analysis approaches and the capabilities of this technology for use in scenarios ranging from bedside hospital care, to clinical evaluation and study, to at-home diagnostics.…”

Section: Introductionsupporting

confidence: 81%

“…The skin also serves as a diffusion barrier 1 , both to block penetration of undesired pathogens 2 , and to prevent excessive transepidermal water loss 3 . The outermost part of skin, the stratum corneum, and the immediate underlying tissue, the epidermis, consist of layered collections of avascular, keratinized cells, in an extracellular lipid matrix [4][5][6][7] .…”

Section: Introductionmentioning

confidence: 99%

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Multimodal epidermal devices for hydration monitoring

et al. 2017

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Precise, quantitative in vivo monitoring of hydration levels in the near surface regions of the skin can be useful in preventing skinbased pathologies, and regulating external appearance. Here we introduce multimodal sensors with important capabilities in this context, rendered in soft, ultrathin, 'skin-like' formats with numerous advantages over alternative technologies, including the ability to establish intimate, conformal contact without applied pressure, and to provide spatiotemporally resolved data on both electrical and thermal transport properties from sensitive regions of the skin. Systematic in vitro studies and computational models establish the underlying measurement principles and associated approaches for determination of temperature, thermal conductivity, thermal diffusivity, volumetric heat capacity, and electrical impedance using simple analysis algorithms. Clinical studies on 20 patients subjected to a variety of external stimuli validate the device operation and allow quantitative comparisons of measurement capabilities to those of existing state-of-the-art tools.

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Section: Introductionsupporting

confidence: 81%

Section: Introductionmentioning

confidence: 99%

Multimodal epidermal devices for hydration monitoring

et al. 2017

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“…Treatment times can vary from a few seconds 66,67 to a few minutes, 36,60 to hours to days. 58,68 The viscosity, surface tension, density, acoustic impedance, and other bulk and interfacial properties of the coupling medium play an important role in enhancement of skin permeability.…”

Section: Clinical Application Of Urdds Transdermal Drug Deliverymentioning

confidence: 99%

Potential and problems in ultrasound-responsive drug delivery systems

Zhao¹,

Du²,

Lu³

et al. 2013

IJN

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Abstract:Ultrasound is an important local stimulus for triggering drug release at the target tissue. Ultrasound-responsive drug delivery systems (URDDS) have become an important research focus in targeted therapy. URDDS include many different formulations, such as microbubbles, nanobubbles, nanodroplets, liposomes, emulsions, and micelles. Drugs that can be loaded into URDDS include small molecules, biomacromolecules, and inorganic substances. Fields of clinical application include anticancer therapy, treatment of ischemic myocardium, induction of an immune response, cartilage tissue engineering, transdermal drug delivery, treatment of Huntington's disease, thrombolysis, and disruption of the blood-brain barrier. This review focuses on recent advances in URDDS, and discusses their formulations, clinical application, and problems, as well as a perspective on their potential use in the future.

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“…The permeation results indicated that MH preparations showed a more enhanced permeation of salicylic acid across excised rat skin than the standard SSD (1% silver sulphadiazine cream). It has been shown that the two parameter Fickian diffusion model and the developed skin porous -pathway theory 6 , have shown that hydration culminates in the induction of new pores /reduction of the tortuosity of the existing pores within the excised rat skin. The permeability of drugs across rat skin may be due to the structural changes in the skin although the exact mechanism is unclear.…”

Section: Antimicrobial Activity Of Mucin-honey Mixturesmentioning

confidence: 99%

Transdermal Permeation of Salicylic Acid Embedded in an Array of formulations Based on Mucinated Honey across Excised Experimental Rat Skin

Adikwu¹,

Ibezim²,

Okafor³

et al. 2012

Journal of Pharmaceutical Research

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This work focuses on the skin permeation properties of drug formulations such as ointments, creams and gels produced using various quantities of mucin, honey and their admixtures (mucinated -honey (MH) containing salicylic acid as the model drug. Permeation studies involved the assessment of the transdermal migration of salicylic acid across excised rat skin at room temperature using phosphate buffered saline as the release medium. Results obtained indicate that formulations containing mucinated honey (MH) showed higher salicylic acid release than those containing only mucin or honey alone. Furthermore, the apparent permeability (P app ) values obtained for ointments varied between 2.036 x 10 -4 to 2.372 x 10 -4 cm 2 S -1 while those obtained for creams ranged from 2.726 -3.027 x 10 -4 cm 2 S -1 . Additionally, the P app values for the gels formulated were between 2.5174 and 2.9368 x 10 -4 cm 2 S -1 . Results for the steady state flux study of the formulations showed that MH formulations have much higher values than those obtained for formulations containing mucin or honey alone. Findings suggest that the materials handled could be possible candidates for the formulation of ointments, creams and gels for topical drug delivery applications to wounds.

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Prediction of steady‐state skin permeabilities of polar and nonpolar permeants across excised pig skin based on measurements of transient diffusion: Characterization of hydration effects on the skin porous pathway

Cited by 41 publications

References 57 publications

Multimodal epidermal devices for hydration monitoring

Multimodal epidermal devices for hydration monitoring

Potential and problems in ultrasound-responsive drug delivery systems

Transdermal Permeation of Salicylic Acid Embedded in an Array of formulations Based on Mucinated Honey across Excised Experimental Rat Skin

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