Percutaneous Absorption of C14-Labeled Triamcinolone Acetonide

Malkinson, Frederick D.

doi:10.1001/archderm.1963.01590220059007

Cited by 48 publications

(5 citation statements)

References 12 publications

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“…Malkinson & Kirschcnbaum (13) in thcir work on absorption of triamcinolone, mention two fac tors which remain to be evaluatcd: (i) dccreascd race of local mctabolic inactivation of the steroid, and (ii) prolonged and dccreased rate of c1rcula tory removal dcpendent on local tissue storage in corium. The pronounccd and prolonged vascular action of the fluorinated steroids rnay be cx plained in part by thcse two postulations.…”

Section: Discussionmentioning

confidence: 99%

Plethysmographic recordings of skin pulses. IV. The vasoconstrictive effect of steroids in normal and stripped skin

1971

Acta Derm Venereol

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Section: Discussionmentioning

confidence: 99%

Plethysmographic recordings of skin pulses. IV. The vasoconstrictive effect of steroids in normal and stripped skin

1971

Acta Derm Venereol

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“…Considerable care must be used to be sure that further increases in topical potency will not result in a proportionate increase in potential systemic effects. Even though a strongly anti-inflammatory derivative may not be absorbed through normal skin or skin stripped of its stratum corneum more readily than its parent, hydrocortisone, and may in fact be absorbed more slowly than hydrocortisone through stripped skin, as shown by Malkinson 13 the absorption of these agents through skin affected by various diseases has not yet been measured. It is reasonable to assume that more absorption takes place through skin affected with an inflammatory disease like psoriasis than through a noninflammatory dermatosis such as alopecia totalis, as demonstrated by Gill and Baxter.8 However, absorption of a compound does not necessarily mean that it reaches the systemic circulation in an active form.…”

Section: Discussionmentioning

confidence: 99%

Adrenal function after topical steroid therapy

March

Rea

Porter

1965

Clin Pharma and Therapeutics

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Suppression of pituitary-adrenal axis activity was observed in one of a series of Department of Dermatology, New York University Schools of Medicine, and the Department of Dermatology and Syphilology, Bellevue HospitalDespite the remarkable increase in potency of the more recently synthesized adrenal corticosteroids, and despite their extremely widespread topical use in dermatologic therapy, very few adverse effects have been reported. Such reactions appear to have been limited to exacerbation of infections (especially in impetigo, in secondarily infected eczemas, and in herpetic lesions of the cornea but not of the skin) and one report of striae in Hexural areas.

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“…At the start of the twentieth century, numerous in vivo trials showed chronic absorption following topical administration by measuring drug amounts in skin, urine, and feces [33]. Primary analytical techniques were purely qualitative and compounds were observed in the blood or urine by examining the change in the assessed sample in terms of color, acidity, or density compared to the normal sample [34].…”

Section: In the Twentieth Century The Emergence Of Topical Productsmentioning

confidence: 99%

Transdermal Patches for the Treatment of Angina Pectoris: An Effective Drug Delivery System-a Review

et al. 2022

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Topical delivery methods have been used since the dawn of time, employed to cure a wide range of ailments and for aesthetic purposes. Transdermal drug delivery has evolved throughout time, with the development of passive and active technologies that have resulted in enhanced distribution, accuracy in drug dosage, and better fulfilment of the requirements of the individual. The search for more powerful pharmaceuticals that can be delivered to the skin through appropriate transdermal technologies will continue to be a focus in the development of drugs for transdermal patches and other forms of delivery. Topical and transdermal distribution has been around for a while, but this review will focus on transdermal patches and how they've evolved. The articles have been searched on different search engines such as Scopus database, Science direct, PubMed, Google scholar, and Bentham science using multiple keywords. An adhesive transdermal patch is applied to the skin and contains medicine that is absorbed into the bloodstream through the skin. It aids in the recovery of an afflicted part of the body. When compared to oral, topical, i. v., and i. m. administration systems, transdermal drug delivery allows a controlled release of the medicine into patients, often by either a porous membrane or by body heat melting small layers of medication embedded in the adhesive. The fundamental drawback of transdermal delivery methods is that the skin is a highly efficient barrier, therefore, only tiny molecules can enter the skin and be administered in this manner.

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Percutaneous Absorption of C14-Labeled Triamcinolone Acetonide

Cited by 48 publications

References 12 publications

Plethysmographic recordings of skin pulses. IV. The vasoconstrictive effect of steroids in normal and stripped skin

Plethysmographic recordings of skin pulses. IV. The vasoconstrictive effect of steroids in normal and stripped skin

Adrenal function after topical steroid therapy

Transdermal Patches for the Treatment of Angina Pectoris: An Effective Drug Delivery System-a Review

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