Percutaneous Absorption

Malkinson, Frederick D.; Rothman, Stephen

doi:10.1007/978-3-642-87657-8_3

Cited by 11 publications

(10 citation statements)

References 133 publications

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“…Der direkte Weg über die Epidermis mit ihren verschiedenen Re sorptionswiderständen [8,11,12], dem Stratum disjunctum und conjunctum inkl. der « Barriere-Schicht» des Stratum lucidum, den nach folgenden vitalen Zellschichten der Epidermis bis hin zum Papillar körper scheidet aus Gründen der Diffusion infolge der physikochemi schen Eigenschaften der Antigene als vorwiegend grossmolekulare, nichtdissoziierbare Proteine aus [2].…”

Section: Von W Gronemeyer Und M D Ebelicunclassified

Der sogenannte «Reibtest», seine Anwendung und klinische Bedeutung

Gronemeyer¹,

Debelić²

1967

Dermatology

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Section: Von W Gronemeyer Und M D Ebelicunclassified

Der sogenannte «Reibtest», seine Anwendung und klinische Bedeutung

Gronemeyer¹,

Debelić²

1967

Dermatology

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“…39,40,43,5051 Variables such as age, sex, ratio of body fat, previous exposure, nutrition, type and amount of skin exposed as well as the specific conditions of exposure will all affect actual absorption. Rates obtained from healthy adults will again tend to underestimate absorption for younger or more sensitive populations.…”

Section: Methodsmentioning

confidence: 99%

The role of skin absorption as a route of exposure for volatile organic compounds (VOCs) in drinking water.

Brown¹,

Bishop²,

Rowan³

1984

Am J Public Health

111

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Assessments of drinking water safety rely on the assumption that ingestion represents the principal route of exposure. A review of the experimental literature revealed that skin penetration rates for solvents are remarkably high, and that the stratum corneum is a less effective barrier to penetration than traditionally assumed.Based on published skin absorption rates, we used Fick's law (JO = Kp A C°) to determine permeability constants for selected compounds. We then calculated dose per kilogram for nine different exposure situations and compared this to the oral dose per kilogram. IntroductionRegulators today face complex problems in assessing the health hazards associated with contamination of drinking water supplies. Due to the general absence of federal drinking water standards for the volatile solvents commonly found in contaminated water, state and local regulatory agencies must decide whether to discontinue or restrict use of water supplies on a case by case basis. Such decisions are heavily, if not exclusively, based on the recommendation of a toxicologist.

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“…The mechanism is still controversial. [12] as well as some other workers, believe that the main absorption is through the appendages, especially the hair follicles, and only to a lesser extent through the sweat ducts. This implies that after contact with the orificial epithelium the pene trating chemical reaches the dermis iirst and the epidermis secondarily.…”

Section: Transepidermal Penetrationmentioning

confidence: 99%