Percutane Katheterisierung der rechten und linken Nebennierenvene beim Menschen

Bette, L; Blaise, H.; Leppla, W; Oertel, G. W.; Weinheimer, B

doi:10.1007/bf01479130

Cited by 13 publications

(1 citation statement)

References 15 publications

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“…Half-maximal effects occurred at 7 pM cortisol when a 24-h treatment was used. Although these concentrations of cortisol are higher than those present in the general circulation, such concentrations are normally present in venous blood from the adrenal cortex [36].…”

Section: Control Of Differentiated Functionmentioning

confidence: 99%

Hormonal regulation of the adrenocortical cell

1980

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Monolayer cultures of bovine and human adrenocortical cells have been used to study regulation of growth and function. Homogeneous bovine adrenocortical cells exhibit a finite life span of approximately 60 generations in culture. Full maintenance of differentiated function (steroid hormone synthesis) requires an inducer such as ACTH and antioxidizing conditions. Full induction of differentiated function occurs only when cellular hypertrophy is stimulated by growth factors such as fibroblast growth factor and serum. ACTH and other agents that increase cellular cAMP inhibit replication but do not block growth factor-induced cellular hypertrophy. ACTH and growth factors together result in a hypertrophied, hyperfunctional cell. Replication ensues only when desensitization to the growth inhibitory effects of ACTH occurs. Cultures of the definitive and fetal zones of the human fetal adrenal cortex synthesize the steroids characteristic of the two zones in vivo. ACTH stimulates production of dehydroepiandrosterone (DHA), the major steroid product of the fetal zone, and of cortisol, the characteristic steroid product of the definitive zone. Prolonged ACTH treatment of fetal zone cultures results in a preferential increase in cortisol production so that the pattern of steroid synthesis becomes that of the definitive zone. The preferential increase in cortisol production by fetal Zone cultures results from induction of 3 beta-hydroxysteroid dehydrogenase, delta 4,5 isomerase activity, which is limiting in fetal zone cells. ACTH thus causes a phenotypic change in fetal zone cells to that of definitive zone cells. In both bovine and human adrenocortical cells, the principal effect of ACTH is to induce full expression of differentiated function. This occurs only under conditions where growth substances and nutrients permit full amplification.

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Section: Control Of Differentiated Functionmentioning

confidence: 99%

Hormonal regulation of the adrenocortical cell

1980

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Radiologische Diagnostik bei arterieller Hypertonie

Braedel¹,

Schieffer²,

Fröhlig³

et al. 1984

Arterielle Hypertonie

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Technical difficulties of selective venous blood sampling in the differential diagnosis of female hyperandrogenism

Sörensen

Moltz

Schwartz

1986

Cardiovasc Intervent Radiol

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To determine glandular steroid release of adrenals and ovaries in female hyperandrogenism, a standardized method for percutaneous transfemoral venous blood sampling was developed. In eight volunteers and 67 patients, catheterization was performed during the early follicular phase (days 3-7; between 8 and 10 a.m.) to reduce interference from cyclic and circadian variations of secretion. Serial samplings reduced the episodic effluent changes. Anatomical variations and collateral flow as well as stress effects and the dosage of contrast media were studied. During catheterization, peripheral cortisol levels did not differ significantly from control groups. Collaterals had no effect on hormone levels. Contrast media increased cortisol effluent levels only when they were sampled following venography. Four-vessel venous sampling was found to be indicated if peripheral testosterone was more than 1.5 ng/ml and/or dehydroepiandrosterone sulfate more than 6,700 ng/ml. If an ovarian (adrenal)/peripheral gradient of testosterone exceeded 2.7 ng/ml, surgical intervention for tumor removal at the site of hormone excess was felt to be necessary.

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Percutane Katheterisierung der rechten und linken Nebennierenvene beim Menschen

Cited by 13 publications

References 15 publications

Hormonal regulation of the adrenocortical cell

Hormonal regulation of the adrenocortical cell

Radiologische Diagnostik bei arterieller Hypertonie

Technical difficulties of selective venous blood sampling in the differential diagnosis of female hyperandrogenism

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