Perconditioning associated to hypertonic saline solution on liver function improvement after ischemia/reperfusion injury

Ribeiro, Rubens Fernando Gonçalves; Couteiro, Rodrigo Paracampo; Monteiro, Andrew Moraes; Rodrigues, Ivone Aline da Silva; Cavalcante, Lainy Carollyne da Costa; Gouveia, Eduardo Henrique Herbster; Galvão, Lucas Nascimento; Lopes, Luiz Renato Oliveira; Yasojima, Edson Yuzur; Brito, Marcus Vinicius Henriques

doi:10.1590/s0102-865020170110000006

Cited by 3 publications

(1 citation statement)

References 20 publications

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“…The reason is that excessive oxygen produces superoxide anion free radicals during reperfusion, possibly aggravating renal dysfunction [28]. Interestingly, hypertonic saline, which has protective effects on ischemia reperfusion, as well as antioxidant and anti-apoptotic effects [29,30], protect kidneys from injury. Furthermore, Kreimier et al showed that hypertonic saline solution effectively improved renal microcirculation [31] and protected shock kidney by infusion of small doses [32].…”

Section: Discussionmentioning

confidence: 99%

Higher Concentration of Hypertonic Saline Shows Better Recovery Effects on Rabbits with Uncontrolled Hemorrhagic Shock

Kang²,

et al. 2019

Med Sci Monit

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Departmental sources Background: Our previous study found a novel fluid combination with better resuscitation effects under hypotensive condition at the early stage of uncontrolled hemorrhagic shock (UHS). However, the optimal recovery concentration of hypertonic saline in this fluid combination remains unknown. This experiment aimed to explore the optimal concentration. Material/Methods: New Zealand white rabbits (n=40) were randomly divided into 5 groups, including a sham-operated group (SO), a shock non-treated group (SNT), a normal saline group (NS), and hypertonic saline groups (4.5% and 7.5%). We established an UHS model and administered various fluid combinations (dose-related sodium chloride solution+crystal-colloidal solution) to the groups followed by monitoring indexes of hemodynamic and renal function, measuring infusion volume and blood loss, and analyzing pathological morphology by hematoxylin and eosin staining. Results: The hypertonic saline groups showed more stable hemodynamic indexes, reduced blood loss, fewer required infusions, and milder decreases in renal function than those of control groups (SNT and NS groups), and exhibited fewer pathological changes in the heart, lung, kidney, and liver. All indexes in the 4.5% and 7.5% groups were better than those of the NS group, and the hemodynamic indexes in the 7.5% group were more stable than those of the 4.5% group (P<0.05), with reduced blood loss and infusion volume and a milder decrease in renal function. Conclusions: The novel fluid combination with 7.5% hypertonic saline group had a better recovery effect at the early stage of UHS before hemostasis compared to that of the 4.5% hypertonic saline group. This result may provide guidance for clinical fluid resuscitation.

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Section: Discussionmentioning

confidence: 99%

Higher Concentration of Hypertonic Saline Shows Better Recovery Effects on Rabbits with Uncontrolled Hemorrhagic Shock

Kang²,

et al. 2019

Med Sci Monit

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Deleterious Effects of Remote Ischaemic Per-conditioning During Lower Limb Ischaemia–Reperfusion in Mice

Guillot¹,

Charles²,

Lejay³

et al. 2021

European Journal of Vascular and Endovascular Surgery

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Remote ischemic conditioning improves rat brain antioxidant defense in a time-dependent mechanism

et al. 2021

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Purpose To clarify the best protocol for performing remote ischemic conditioning and to minimize the consequences of ischemia and reperfusion syndrome in brain, the present study aimed to evaluate different time protocols and the relation of the organs and the antioxidant effects of this technique. Methods The rat’s left femoral artery was clamped with a microvascular clamp in times that ranged from 1 to 5 minutes, according to the corresponding group. After the cycles of remote ischemic conditioning and a reperfusion of 20 minutes, the brain and the left gastrocnemius were collected. The samples were used to measure glutathione peroxidase, glutathione reductase and catalase levels. Results In the gastrocnemius, the 4-minute protocol increased the catalase concentration compared to the 1-minute protocol, but the latter increased both glutathione peroxidase and glutathione reductase compared to the former. On the other hand, the brain demonstrated higher catalase and glutathione peroxidase in 5-minute group, and the 3-minute group reached higher values of glutathione reductase. Conclusions Remote ischemic conditioning increases brain antioxidant capacity in a time-dependent way, while muscle presents higher protection on 1-minute cycles and tends to decrease its defence with longer cycles of intermittent occlusions of the femoral artery.

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Perconditioning associated to hypertonic saline solution on liver function improvement after ischemia/reperfusion injury

Cited by 3 publications

References 20 publications

Higher Concentration of Hypertonic Saline Shows Better Recovery Effects on Rabbits with Uncontrolled Hemorrhagic Shock

Higher Concentration of Hypertonic Saline Shows Better Recovery Effects on Rabbits with Uncontrolled Hemorrhagic Shock

Deleterious Effects of Remote Ischaemic Per-conditioning During Lower Limb Ischaemia–Reperfusion in Mice

Remote ischemic conditioning improves rat brain antioxidant defense in a time-dependent mechanism

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