Perception of Side Effects of Chemotherapy among Cancer Patients in B.P. Koirala Memorial Cancer Hospital Bharatpur, Nepal

Gurung, Sharmila; Pandey, Radha Acharya

doi:10.3126/jcmsn.v11i4.14319

Cited by 6 publications

(4 citation statements)

References 10 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“… 3 , 9 On the other hand, side effects of chemotherapeutic agents are other concerns. 21 The mi-RNAs like miR-155 play a crucial role in cell fate as small potent molecules with different targets. Rokah et al demonstrated that Philadelphia chromosome in CML cells can downregulate the expression of miR-155.…”

Section: Discussionmentioning

confidence: 99%

miR-155 effectively induces apoptosis in K562 Philadelphia positive cell line through upregulation of p27kip1

Fathabad¹,

Karimipoor²,

Alizadeh³

et al. 2017

Bioimpacts

View full text Add to dashboard Cite

Introduction: Chronic myelogenous leukemia (CML) is a myeloproliferative disorder caused by the Philadelphia chromosome translocation, at (9; 22), which results in BCR-ABL fusion tyrosine kinase oncoprotein. This fusion induces down-regulation of miR-155. Upregulation of miR-155 can influence cell fate via the effect on p27kip1 and apoptosis. The aim of this study was to induce apoptosis in K562 CML cell line by overexpression of miR-155. Methods: The K562 cell line was transfected with pLenti-III-pre mir155-GFP constructs through electroporation. Then, overexpression of miR-155 as well as the expression level of p27kip1 and c-Myc was analyzed by quantitative PCR (qPCR). The level of p27 (Kip1) protein expression was measured by Western blot and the Annexin V method was carried out to investigate apoptosis. Results: Flow cytometric analysis results of K562 cells transfected with pLenti-III-pre mir155-GFP construct showed a significant increase in cell apoptosis. Gene expression and protein level of p27kip1 were upregulated. However, there was no change in c-Myc expression profile. Conclusion: miR-155 could be a promising approach to aid in the treatment of CML. However, further studies are required in this respect.

show abstract

Section: Discussionmentioning

confidence: 99%

miR-155 effectively induces apoptosis in K562 Philadelphia positive cell line through upregulation of p27kip1

Fathabad¹,

Karimipoor²,

Alizadeh³

et al. 2017

Bioimpacts

View full text Add to dashboard Cite

show abstract

“…Chemotherapeutic drugs have side effects because in addition to destroying the actively dividing cancer cells, they damage the actively growing normal cells (5) . These side effects of chemotherapy affect the patients' daily life and affect the different body system resulting in physical, psychological and cognitive side effects (6) . Chemotherapy treatment for cancer has been associated with fatigue, pain, depressive symptoms which is main trigger for suicidal behavior, and disturbed sleep, poor sleep quality is a risk factor for exacerbation of chronic pain (7).…”

Section: Introductionmentioning

confidence: 99%

Self-Efficacy, Pain and Suicidal Thoughts among Women with Breast Cancer Undergoing Chemotherapy

Abd-Elrhman

Abdelkhalek

Hady

2022

Zagazig Nursing Journal

View full text Add to dashboard Cite

Background: Breast cancer continues to be the most frequently diagnosed cancer in women worldwide. Its diagnosis and treatment often results in a stressful life event and high levels of psychological distress. Pain, hopelessness, and suicidal ideation are common in patient with breast cancer. Aim of the study: To identify self-efficacy, pain and suicidal thoughts among women with breast cancer undergoing chemotherapy .Subjects and method: Research design: A Cross sectional descriptive design was used. Setting: The present study was done at oncology outpatient clinic at Zagazig university hospitals, Subjects: 305 patients were selected for the study by systemic random sampling technique. Tools of data collection: Three tools were used, the first tool composed of two parts: socio-demographic data sheet, and Symptom-Management Self-Efficacy Scale-Breast Cancer The second tool was the Numerical Rating Scale and the third tool was Suicide Probability Scale. Results: The study findings showed that 51.1% of breast cancer women had low score regarding self-efficacy, 68.2% had moderate pain and 54.8%had moderate score regarding suicide probability .Higher percentage of them who had severe score of suicide probability and severe pain aged 40-60 years, were not working, had moderate education, were widow, had not enough income and at fourth degree of cancer. The findings also indicated that there was statistically significant relation between total score of self-efficacy, pain intensity and suicide probability. Conclusions: The Study results proven that more than half of breast cancer patients had low score regarding self-efficacy and moderate score regarding suicide probability. Additionally, more than two third of breast cancer patients had moderate pain. Moreover, reduced self-efficacy among breast cancer patients is particularly associated with pain experience and current suicidal thoughts. Recommendations: Developing Psycho-educational program focus on preventing suicidal thought, reducing pain and increasing self-efficacy in breast cancer women.

show abstract

“…In addition to affecting the physical condition, recent research such as that conducted by Gurung and Pandey in Nepal or Sasaki, et al in Japan stated that chemotherapy also affects the patient's non-physical condition such as work, household duties or the patient's partner, this is even more complained by patients than physical problems (Gurung & Pandey, 2016;Sasaki et al, 2017). This indicates a possible shift from the impact of chemotherapy that is experienced based on the patient's own perceptions.…”

Section: Introductionmentioning

confidence: 99%

“…Likewise with cancer patients who undergo chemotherapy. The perception or assessment of each patient regarding the side effects experienced is also different (Gurung & Pandey, 2016).…”

Section: Introductionmentioning

confidence: 99%

Perception of Cancer Patients on Chemotherapy Side Effects

Indra¹,

Saputra²

2021

Jurnal Riset Kesehatan

View full text Add to dashboard Cite

Chemotherapy causes various side effects that can affect the patient's physical or non-physical condition. Patients' perceptions or ratings of these side effects vary. This study aimed to identify cancer patients' perceptions of the side effects of chemotherapy they are undergoing. The descriptive study was conducted on 84 samples, namely cancer patients aged 20 years who had undergone chemotherapy at least once before. Data collection using a questionnaire that has been tested for validity and reliability. Data analysis was carried out descriptively with frequency distribution. The results showed that the perception of the physical side effects of chemotherapy that was considered very disturbing by the patient (severe symptoms) was nausea (59.5%), feeling of weakness (36.9%), hair loss (35.7%), vomiting. (29.8%), loss of appetite (28.6%). %), weight loss (27.4%), insomnia and skin discoloration (19% each), headache (16.7%) and fever (15.5%). When the perception of non-physical side effects was fear of death, affecting work/household duties and feeling fear (15.5% each), feeling anxious about my life, and the presence of family members I have to take care (14.3% each). The most disturbing side effects of chemotherapy are physical problems. The health service is expected to increase interventions to minimize the side effects of chemotherapy.

show abstract

Perception of Side Effects of Chemotherapy among Cancer Patients in B.P. Koirala Memorial Cancer Hospital Bharatpur, Nepal

Cited by 6 publications

References 10 publications

miR-155 effectively induces apoptosis in K562 Philadelphia positive cell line through upregulation of p27kip1

miR-155 effectively induces apoptosis in K562 Philadelphia positive cell line through upregulation of p27kip1

Self-Efficacy, Pain and Suicidal Thoughts among Women with Breast Cancer Undergoing Chemotherapy

Perception of Cancer Patients on Chemotherapy Side Effects

Contact Info

Product

Resources

About