Researchers need to investigate global life-threatening problems tied to agriculture such as food insecurity and malnutrition pandemics. This chapter reviews empirical fact-based state-of-the-art literature underlying the agri-business adoption barriers and the agriculture food insecurity crises. The authors focus their effort on identifying the hot spots of global agriculture problems, in developing nations. They use critical analysis to identify the most pressing issues and controversies surrounding West Africa. They then explore empirical literature suggesting possible remedies and future research needs to resolve the agriculture problems, in a way that these concepts would generalize globally and be of interest to other scholars. They produce several conceptual models to assist future agriculture research scholars including keyword thematic diagrams, cross-case subject analysis, topic contingency analysis, and literature topic synthesis. They then focus on probable solutions and they create several conceptual models to summarize those. They close with recommendations for future research.