Percent true calcium absorption, mineral metabolism, and bone mass in children with arthritis: Effect of supplementation with vitamin D<sub>3</sub> and calcium

Hillman, Laura S.; Cassidy, James T.; Chanetsa, Fungai; Hewett, John E.; Higgins, Barry; Robertson, Janet

doi:10.1002/art.23809

Cited by 25 publications

(23 citation statements)

References 34 publications

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“…In a U.S. study, black adolescent girls had lower 25-hydroxyvitamin D concentrations than white girls, but calcium absorption and retention were unrelated to 25-hydroxyvitamin D or 1,25-dihydroxyvitamin D concentrations (29). In a group of children with arthritis, supplemental vitamin D 3 , 2000 IU/d for 6 months, had no effect on calcium absorption, irrespective of whether it was given with supplemental calcium (30). One strength of our study is it is the first to compare directly the effect of both vitamin D 2 and vitamin D 3 administration on calcium absorption in children.…”

Section: Discussionmentioning

confidence: 97%

The Effect of Vitamin D2 and Vitamin D3 on Intestinal Calcium Absorption in Nigerian Children with Rickets

Thacher

Obadofin

O’Brien

et al. 2009

The Journal of Clinical Endocrinology &Amp; Metabolism

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Section: Discussionmentioning

confidence: 97%

The Effect of Vitamin D2 and Vitamin D3 on Intestinal Calcium Absorption in Nigerian Children with Rickets

Thacher

Obadofin

O’Brien

et al. 2009

The Journal of Clinical Endocrinology &Amp; Metabolism

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“…A previous study showed significantly lower osteocalcin and alkaline phosphatase concentrations in individuals with JIA compared to controls, suggesting reduced bone formation (14). Lower calcium concentrations in the JIA group, with no difference in 25(OH)D concentrations may be explained by the reduced capacity for mineral absorption described in children with arthritis (17). A study in animal We did not find an association between 25(OH)D concentrations with either disease activity or duration.…”

Section: Discussionmentioning

confidence: 56%

“…However, only a few studies have assessed the serum concentrations of 25(OH)D in children and adolescents with JIA (14)(15)(16)(17).…”

Section: Introductionmentioning

confidence: 99%

Serum 25-hydroxyvitamin D and biochemical markers of bone metabolism in patients with juvenile idiopathic arthritis

Munekata¹,

Terreri²,

Peracchi³

et al. 2013

Braz. J. Med. Biol. Res.

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Our objective was to evaluate the concentrations of serum 25-hydroxyvitamin D [25(OH)D], serum calcium, serum phosphorus, alkaline phosphatase, and parathormone (PTH) in patients with polyarticular juvenile idiopathic arthritis (JIA) and to associate them with disease duration and activity, bone mineral density and use of medications. In a cross-sectional and controlled study, 30 patients with polyarticular JIA were evaluated and compared to 30 healthy individuals matched for age and gender. Clinical status, anthropometry, laboratory markers in both patients and controls, and bone mineral density, only in the patients, were measured. Of the 30 patients included in the study, 23 (76.7%) were female and 16 (53.3%) non-Caucasian; mean age was 14 years (range = 4 to 20 years). Mean disease duration was 5 years (range = 1 to 12 years). The mean concentrations of serum albumin-corrected calcium (9.04 ± 0.41 mg/dL) and alkaline phosphatase (153.3 ± 100.1 IU) were significantly lower in patients with JIA than in controls (P , 0.0001 and P = 0.001, respectively). No differences in 25(OH)D, PTH or serum phosphorus were observed between JIA and control subjects. Regarding 25(OH)D concentration, 8 patients (26.7%) and 5 controls (16.7%) had 25(OH)D concentrations compatible with deficiency (lower than 20 ng/mL) and 14 patients (46.7%) and 18 controls (60%) had concentrations compatible with insufficiency (20-32 ng/mL). These values were not associated with disease activity, use of medications or bone mineral density. We observed a high frequency of 25(OH)D insufficiency and deficiency in the study sample. The compromised bone metabolism emphasizes the importance of follow-up of JIA patients.

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“…En otro estudio se pone de manifiesto que la suplementación con 2.000 UI de vitamina D3 diarias, aumenta la concentración sérica de 25 (OH) D y los niveles de calcio, pero no mejoran la masa ósea. Resultados similares se obtuvieron con la suplementación de 1.000 mg de calcio al día 27 .…”

Section: Lactancia Maternalunclassified

Recomendaciones dietéticas en la artritis reumatoide

Alhambra-Expósito

Arjonilla-Sampedro

Molina-Puerta

et al. 2013

Rev Esp Nutr Hum Diet

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La artritis reumatoide es una enfermedad sistémica crónica, con gran impacto en la vida social, emocional y física de los pacientes. Desde hace décadas, se han utilizado distintas dietas para tratar de mejorar los síntomas de las personas que la padecen. En este artículo se revisan los posibles beneficios de la terapia dietética en la artritis reumatoide. Los objetivos nutricionales en esta patología son frenar la pérdida de masa ósea, favorecer la recuperación de fracturas óseas y mejorar los trastornos inflamatorios asociadas al hueso y a las articulaciones. En general, se recomiendan dietas bajas en grasas saturadas, ricas en grasas polinsaturadas: omega 3 y omega 6, en hidratos de carbono complejos y fibra. Recomendaciones dietéticas en la artritis reumatoide

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Percent true calcium absorption, mineral metabolism, and bone mass in children with arthritis: Effect of supplementation with vitamin D₃ and calcium

Abstract: The findings of this study indicate that percent true calcium absorption is low-normal in children with arthritis. Vitamin D3 at 2,000 IU/day increases serum 25(OH)D and calcium levels but does not improve bone mass accretion. Calcium at 1,000 mg/day also failed to improve bone mass.

Cited by 25 publications

References 34 publications

The Effect of Vitamin D2 and Vitamin D3 on Intestinal Calcium Absorption in Nigerian Children with Rickets

The Effect of Vitamin D2 and Vitamin D3 on Intestinal Calcium Absorption in Nigerian Children with Rickets

Serum 25-hydroxyvitamin D and biochemical markers of bone metabolism in patients with juvenile idiopathic arthritis

Recomendaciones dietéticas en la artritis reumatoide

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Percent true calcium absorption, mineral metabolism, and bone mass in children with arthritis: Effect of supplementation with vitamin D3 and calcium

Abstract: The findings of this study indicate that percent true calcium absorption is low-normal in children with arthritis. Vitamin D3 at 2,000 IU/day increases serum 25(OH)D and calcium levels but does not improve bone mass accretion. Calcium at 1,000 mg/day also failed to improve bone mass.

Cited by 25 publications

References 34 publications

The Effect of Vitamin D2 and Vitamin D3 on Intestinal Calcium Absorption in Nigerian Children with Rickets

The Effect of Vitamin D2 and Vitamin D3 on Intestinal Calcium Absorption in Nigerian Children with Rickets

Serum 25-hydroxyvitamin D and biochemical markers of bone metabolism in patients with juvenile idiopathic arthritis

Recomendaciones dietéticas en la artritis reumatoide

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Percent true calcium absorption, mineral metabolism, and bone mass in children with arthritis: Effect of supplementation with vitamin D₃ and calcium