The Effect of Vitamin D2 and Vitamin D3 on Intestinal Calcium Absorption in Nigerian Children with Rickets

Thacher, Tom D.; Obadofin, Michael O.; O’Brien, Kimberly; Abrams, Steven A.

doi:10.1210/jc.2009-0018

Cited by 64 publications

(40 citation statements)

References 33 publications

(48 reference statements)

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“…A similar correlation between 25(OH)D and 1, 25(OH) 2 D was previously observed (24,29). An increase of 25(OH)D within the normal range led to a subsequent increase of serum 1,25(OH) 2 D concentrations (28,30,31). Thus, oral administration of 25(OH)D in doses of 20-25 mg/d (800-1000 IU/d) for 2-12 wk and a single dose of vitamin D (1.25 mg) were reported to increase 1,25(OH) 2 D concentrations (28,30,32).…”

Section: Discussionsupporting

confidence: 79%

Serum 25-Hydroxyvitamin D Is a Predictor of Serum 1,25-Dihydroxyvitamin D in Overweight and Obese Patients,

Lagunova

Porojnicu

Vieth

et al. 2011

The Journal of Nutrition

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Recent research suggests that 1,25-dihydroxyvitamin D [1,25(OH)(2)D], a steroid hormone that regulates calcium homeostasis, may also play a role in the development and progression of cancer, multiple sclerosis, cardiovascular, and other diseases. Decreased serum 1,25(OH)(2)D concentrations are often observed in overweight and obese patients. However, little is known about the factors that may influence 1,25(OH)(2)D renal synthesis, because it is generally accepted that serum 1,25(OH)(2)D concentration is strictly regulated by parathyroid hormone and serum concentrations of calcium and phosphorus. In this study, the associations among serum 1,25(OH)(2)D, serum 25-hydroxyvitamin D [25(OH)D], and body composition were analyzed in 1779 patients with excess body weight registered in a Metabolic and Medical Lifestyle Management Clinic in Oslo, Norway. According to our results, serum 25(OH)D, adiposity, age, season of blood sampling, and gender directly influence serum 1,25(OH)(2)D (r = 0.33; P < 0.001), with serum 25(OH)D being the strongest predictor for serum 1,25(OH)(2)D. The 1,25(OH)(2)D concentrations were 25.4 pmol/L (95% Cl: 19.3-31.5; P < 0.001) lower in the lowest 25(OH)D quartile to compared with highest quartile. A seasonal variation was observed for both vitamin D metabolites. Thus, our results suggest that in patients with excess body weight, serum 1,25(OH)(2)D concentrations were associated with 25(OH)D and varied during the year. Therefore, it may also be valuable to measure both serum 25(OH)D and 1,25(OH)(2)D for the evaluation of vitamin D status in overweight and obese persons.

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Section: Discussionsupporting

confidence: 79%

Serum 25-Hydroxyvitamin D Is a Predictor of Serum 1,25-Dihydroxyvitamin D in Overweight and Obese Patients,

Lagunova

Porojnicu

Vieth

et al. 2011

The Journal of Nutrition

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“…In contrast, only 70 mg vitamin D 3 /wk (w10 mg/d) plus alendronate in postmenopausal women increased fractional calcium absorption by 0.07, but the large rise was attributed to the alendronate effect on serum PTH and 1,25(OH) 2 D 3 (34). In adolescent girls and young children with rickets, supplementation with vitamin D 3 showed no increase in calcium absorption (15,35). Several factors may have contributed to discrepancies in the findings between studies, such as baseline 25(OH)D and PTH concentrations, the calcium-absorption method, calcium intake, impaired renal function, or variable doses of vitamin D used in these studies.…”

Section: Discussionmentioning

confidence: 99%

Vitamin D supplementation and calcium absorption during caloric restriction: a randomized double-blind trial

Shapses¹,

Sukumar²,

Schneider³

et al. 2013

The American Journal of Clinical Nutrition

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“…Several observational studies have found that in such children calcium is very effective in treating rickets while vitamin D is ineffective [173,174]. This is supported by a study of nutritional rickets due to very low calcium intakes in which vitamin D supplementation had no effect on the fractional intestinal calcium absorption, despite raising the mean 25(OH)D level from a baseline of 50 nmol/L to 75 nmol/L [175].…”

Section: Human Data Relevant To Vitamin D and The Neonate And Infantmentioning

confidence: 92%

Fetus, Neonate and Infant

Kovacs

2011

Vitamin D

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The Effect of Vitamin D2 and Vitamin D3 on Intestinal Calcium Absorption in Nigerian Children with Rickets

Abstract: Despite similar increases in 25-hydroxyvitamin D and 1,25-dihydroxyvitamin D with vitamin D(2) or vitamin D(3), fractional calcium absorption did not increase, indicating that rickets in Nigerian children is not primarily due to vitamin D-deficient calcium malabsorption.

Cited by 64 publications

References 33 publications

Serum 25-Hydroxyvitamin D Is a Predictor of Serum 1,25-Dihydroxyvitamin D in Overweight and Obese Patients,

Serum 25-Hydroxyvitamin D Is a Predictor of Serum 1,25-Dihydroxyvitamin D in Overweight and Obese Patients,

Vitamin D supplementation and calcium absorption during caloric restriction: a randomized double-blind trial

Fetus, Neonate and Infant

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