Percent Gleason Grade 4/5 as Prognostic Factor in Prostate Cancer Diagnosed at Transurethral Resection

Egevad, Lars; Granfors, Torvald; Karlberg, Lars; Bergh, Anders; STATTIN, P??R

doi:10.1097/00005392-200208000-00023

Cited by 20 publications

(34 citation statements)

References 18 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Percent high-grade cancer (%GP 4/5) has been suggested as a prognostic factor for prostate cancer [13][14][15][16]. The Gleason grading system was originally a nine-tiered system, but only some of the grades are actually commonly used.…”

Section: Discussionmentioning

confidence: 99%

Interactive digital slides with heat maps: a novel method to improve the reproducibility of Gleason grading

et al. 2011

Self Cite

View full text Add to dashboard Cite

Our aims were to analyze reporting of Gleason pattern (GP) 3 and 4 prostate cancer with the ISUP 2005 Gleason grading and to collect consensus cases for standardization. We scanned 25 prostate biopsy cores diagnosed as Gleason score (GS) 6-7. Fifteen genitourinary pathologists graded the digital slides and circled GP 4 and 5 in a slide viewer. Grading difficulty was scored as 1-3. GP 4 components were classified as Type 1 (cribriform), 2 (fused) or 3 (poorly formed glands). A GS 5-6, 7 (3+4), 7 (4+3), 8-9 was given in 29%, 41%, 19% and 10% (mean GS 6.84,). In 15 cases, at least 67% of observers agreed on GS groups (consensus cases). Mean interobserver weighted kappa for GS groups was 0.43.Mean difficulty scores in consensus and non-consensus cases were 1.44 and 1.66 (p = 0.003).Pattern 4 Types 1, 2 and 3 were seen in 28%, 86% and 67% of GP 4. All three co-existed in 16% (11% and 23% in consensus and non-consensus cases, p = 0.03). Average estimated and calculated %GP 4/5 were 29% and 16%. After individual review, the experts met to analyze diagnostic difficulties. Areas of GP 4 and 5 were displayed as heat maps, which were helpful for identifying contentious areas. A key problem was to agree on minimal criteria for small foci of GP 4. In summary, the detection threshold for GP 4 in NBX needs to be better defined.This set of consensus cases may be useful for standardization.

show abstract

Section: Discussionmentioning

confidence: 99%

Interactive digital slides with heat maps: a novel method to improve the reproducibility of Gleason grading

et al. 2011

Self Cite

View full text Add to dashboard Cite

show abstract

“…One proposed morphological approach is quantitation of amount of high-grade (percentage Gleason pattern 4 or 5) carcinoma. 44,46 In TURP chips, the percentage of score 4/5 was the most powerful predictor of death for prostate cancer. 46 The percentage of a tumor that is Gleason pattern 4 or 5 (4/5) in the whole gland has been related to cancer volume, the presence of lymph node metastasis, and progression after radical prostatectomy.…”

Section: Experimental Approachesmentioning

confidence: 99%

“…44,46 In TURP chips, the percentage of score 4/5 was the most powerful predictor of death for prostate cancer. 46 The percentage of a tumor that is Gleason pattern 4 or 5 (4/5) in the whole gland has been related to cancer volume, the presence of lymph node metastasis, and progression after radical prostatectomy. Thus, this factor may be utilized in the reporting of grade in radical prostatectomy specimens in the future, but validation at other institutions and the questions of reliability of the estimate (interobserver agreement) and how best to quantitate % 4/5 disease must be addressed.…”

Section: Experimental Approachesmentioning

confidence: 99%

“…If a tertiary Gleason pattern 4 or 5 is detected, it should definitely be noted. 46 Radical prostatectomy Gleason grade should be assigned in standard fashion, with the most common and the secondary Gleason patterns in the whole gland used to determine the primary and secondary Gleason grades. There are published recommendations to grade only the 'dominant nodule' 28 or to report separate grades for separate tumors in the whole gland, 17 but many prostate glands lack a dominant nodule and no data exist to support reporting of separate tumors.…”

Section: Reportingmentioning

confidence: 99%

See 1 more Smart Citation

Gleason grading and prognostic factors in carcinoma of the prostate

2004

View full text Add to dashboard Cite

“…Tümörü oluşturan yüksek dereceli (Gleason patern 4 veya 5) prostat kanserinin yüzde-si önemli bir prognostik göstergedir [27,28] [29,30].…”

Section: Gleason Patern 5 (Grade 5)unclassified

Prostat Kanser Patolojisi

Baydar¹,

Fakultesi²

2018

Trd Sem

View full text Add to dashboard Cite

Percent Gleason Grade 4/5 as Prognostic Factor in Prostate Cancer Diagnosed at Transurethral Resection

Abstract: Percent Gleason grade 4/5, modified Gleason score and Gleason score are predictors of disease specific survival in patients with prostate cancer on deferred treatment. Our study indicates that any grade 4/5 pattern impairs the prognosis significantly.

Cited by 20 publications

References 18 publications

Interactive digital slides with heat maps: a novel method to improve the reproducibility of Gleason grading

Interactive digital slides with heat maps: a novel method to improve the reproducibility of Gleason grading

Gleason grading and prognostic factors in carcinoma of the prostate

Prostat Kanser Patolojisi

Contact Info

Product

Resources

About