Gleason grading and prognostic factors in carcinoma of the prostate

Humphrey, Peter A.

doi:10.1038/modpathol.3800054

Cited by 417 publications

(352 citation statements)

References 58 publications

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“…Some studies have reported that patients with high Gleason scores (≥ 8) had poor prognoses [29], but others found that the Gleason scores had limited prognostic value for prostate cancer patients. Our study suggested that the biopsy Gleason score could predict PFS, but not OS.…”

Section: Analysis Of the Predictors For Osmentioning

confidence: 99%

Prostate-specific antigen half-life: a new predictor of progression-free survival and overall survival in Chinese prostate cancer patients

et al. 2009

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We investigated the potential value of prostate-specific antigen half-life (PSAHL) and decreasing velocity (PSAVd) to predict progression-free survival (PFS) and overall survival (OS) in Chinese patients with prostate cancer. A total of 153 patients treated with hormonal therapy were included in the study. Of these, 78 patients progressed to hormonerefractory prostate cancer (HRPC) and 24 patients died by the end of follow-up. PSAHL was defined as the time during which prostate-specific antigen (PSA) concentration became half of the initial value during the first hormonal therapy. PSAVd reflected the decreasing velocity of PSA during the first hormonal therapy. PFS was defined as the interval from the beginning of hormonal therapy to HRPC. Cox proportional hazards regression analysis was used to evaluate whether PSAHL and PSAVd were significantly associated with PFS and OS. The median PSAHL and PSAVd were 0.50 months and 33.8 ng mL −1 per month. The median PFS and OS were 22.7 months (95% confidence interval [CI], 22.0-29.6 months) and 43.5 months (95% CI, 37.9-48.4 months), respectively. On univariate and multivariate analysis, long PSAHL (> 0.5 months), metastatic disease, high biopsy Gleason scores (≥ 8) and high nadir PSA (> 0.4 ng mL −1 ) were all found to be significantly associated with short PFS. Long PSAHL, high nadir PSA and short PSA doubling time (PSADT ≤ 2.0 months) were significantly associated with short OS. There were no significant relationships between PSAVd and either PFS or OS. Thus, PSAHL is a promising new independent predictor of survival. Patients with long PSAHL were identified as those at high risk for a relatively short PFS and OS.

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Section: Analysis Of the Predictors For Osmentioning

confidence: 99%

Prostate-specific antigen half-life: a new predictor of progression-free survival and overall survival in Chinese prostate cancer patients

et al. 2009

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“…Human prostatic carcinomas (PCs) are graded by pathologists using the Gleason system (Gleason, 1966), which remains one of the most powerful prognostic indicators in PC (Humphrey, 2004;Young et al, 2000). An important feature of the Gleason grading is that it does not rely on detailed assessment of nuclear morphology, but it assigns numerical grades (1)(2)(3)(4)(5) based upon the architectural patterns of the tumour that are best evaluated at low power magnification.…”

Section: Introductionmentioning

confidence: 99%

Proposal of Gleason-like grading system of canine prostate carcinoma in veterinary pathology practice

Palmieri

Grieco

2015

Research in Veterinary Science

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A C C E P T E D M A N U S C R I P T ACCEPTED MANUSCRIPTA single primary growth pattern was observed in 28 cases, a secondary pattern in 11 cases and a tertiary pattern in 6 cases. Cribriform, solid and small acinar/ductal were the most common primary, secondary and tertiary morphological patterns, respectively.The highest Gleason score (GS10) was obtained in 46.7% of cases. Nine of 14 metastasizing cases were classified as GS10. Gleason pattern 5 was present in 33 of cases.This study suggests that the modified Gleason grading, based on specific histological growth patterns existing in canine prostate carcinomas, may be accepted as a grading system for histopathology in the practice settings in order to complete the clinical assessment for the best management of the patient.

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“…Obje metode interpretiraju standardne tkivne rezove obojene hemalaun-eozinom u svjetlosnoj mikroskopiji. Gleasonov sustav bazira se na arhitekturalnim karakteristikama rasta tumora dok metoda SZO-a uz nuklearnu anaplaziju uključuje i sposobnost tumora da formira žlijezde 16 . Dr. Donald F. Gleason, patolog iz Minnesote (SAD), zajedno s članovima Veterans Administration Cooperative Urological Research Group objavio je rezultate randomizirane kliničke studije koja je na velikoj skupini od 5.000 pacijenata s karcinomom prostate testirala sustav gradiranja u odnosu na preživljenje 17 .…”

Section: Tip Tumoraunclassified

Pathohistological diagnosis of prostate cancer

2017

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Sažetak. Rak prostate najčešći je malignom u muškaraca u Europi i SAD-u, raznolik u kliničkoj prezentaciji, patohistološkoj slici, obrascima rasta i širenja. Kada se rak prostate otkrije u ranom stadiju postotak izlječenja je visok. Definitivna verifikacija je patohistološka s individualnom procjenom agresivnog potencijala tumora kroz prognostičke parametre kao što su Gleasonov gradus/gradusna skupina, postotak i broj zahvaćenih cilindara tumorom u iglenoj biopsiji, stadij i pozitivan rub kod prostatektomije. Ovi čimbenici danas značajno utječu na izbor i protokole terapija, ali u ranom stadiju ne mogu prepoznati lokalizirani, klinički značajan karcinom koji će sigurno izazvati metastatku bolest te zahtijeva liječenje. Stoga su se istraživanja danas usredotočila na molekularne biomarkere koji su važni u prognozi, patogenezi te kao ciljne molekule za moguću terapiju. Članak pridonosi boljem razumijevanju patohistološkog nalaza i novih činjenica u molekularnoj patogenezi tumora, što je važno za zbrinjavanje pacijenata s rakom prostate.Ključne riječi: karcinom prostate; molekularni biomarkeri; prognostički čimbenici Abstract. Prostate cancer (PCa) is the most common male cancer in Europe and the US. The early diagnosis relies on prostate specific antigen serum test, digito-rectal and ultrasound exmination. Definitive verification is pathohistological with individual assesment of aggressiveness of the tumor potential through prognostic parameters such as Gleason gradus/grade groups, percentage and number of affected cilinders in the biopsy, stage and positive margins in prostatectomy. These parameters significantly affect the choice and protocol of therapies but can not identify a localized, clinically significant cancer that will certainly cause metastatic disease and require treatment. Therefore, researchers focused on molecular biomarkers that are important in prognosis, pathogenesis, and as a target molecules for possible therapy. The article contributes to a better understanding of the pathohistological findings and new facts about the molecular pathogenesis of tumors, which are important for the care of patients with prostate cancer.

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Gleason grading and prognostic factors in carcinoma of the prostate

Cited by 417 publications

References 58 publications

Prostate-specific antigen half-life: a new predictor of progression-free survival and overall survival in Chinese prostate cancer patients

Prostate-specific antigen half-life: a new predictor of progression-free survival and overall survival in Chinese prostate cancer patients

Proposal of Gleason-like grading system of canine prostate carcinoma in veterinary pathology practice

Pathohistological diagnosis of prostate cancer

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