Perceived severity of restless legs syndrome across the female life cycle

Ghorayeb, Imad; Bioulac, Bernard; Scribans, Cédric; Tison, François

doi:10.1016/j.sleep.2007.07.018

Cited by 51 publications

(28 citation statements)

References 28 publications

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“…The last trimester of pregnancy is often described as the most critical [8]. As in our study, 25% of the women stated the worsening of RLS symptoms during pregnancy, despite this, the IRLS did not significantly differ according to the trimester of pregnancy [14,15,25]. However, the main syndrome characteristics of the RLS during pregnancy are similar to those of the general population [13,14].…”

Section: Discussionsupporting

confidence: 54%

“…RLS in prior pregnancies or RLS in past while non-pregnant are also important risk factors for RLS during pregnancy [14,17] since only 55.4% in our study had de novo RLS during the index pregnancy. This effect also occurs later in life many years after the pregnancy [28] since RLS seems to be more frequent and more severe among women with previous pregnancies who had a higher mean IRLS score than women without children [25]. However, we were not able to confirm this data since mean the IRLS score was not statistically different among women without previous pregnancies (17.9 ± 7.1) than those with one pregnancy (18.0 ± 7.0), two (18.6 ± 7.9) or more than two pregnancies (19.4 ± 7.6).…”

Section: Discussionmentioning

confidence: 99%

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Restless Legs Syndrome and Pregnancy: A Questionnaire Study in the Poitiers District, France

Neau

Porcheron²,

Mathis³

et al. 2010

Eur Neurol

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Aims: To perform a large and detailed epidemiologic study on restless legs syndrome (RLS) during pregnancy in a European country. Methods: A cross-sectional questionnaire survey. The questionnaire was distributed by the medical staff in different outpatient waiting rooms (obstetrics and gynecology department of the university hospital, obstetrics and gynecology department of a private clinic, private midwives, private obstetrician-gynecologists, radiological centers before fetal ultrasound examination and general practitioners) in a French town and its surrounding area (200,000 inhabitants): A woman was considered affected if she met the International RLS Study Group criteria for RLS diagnosis. Results: 1,022 pregnant women living in a French town were included. 24% of women were affected by RLS during their pregnancy. The disease was strongly related to the third trimester of pregnancy and had a significant impact on sleep leading to severe nocturnal and diurnal consequences with a high consumption of sleep medication. Conclusions: RLS affects one quarter of pregnant women, essentially during the third trimester and represents an important public health issue with sleep medication intake.

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Section: Discussionsupporting

confidence: 54%

Section: Discussionmentioning

confidence: 99%

Restless Legs Syndrome and Pregnancy: A Questionnaire Study in the Poitiers District, France

Neau

Porcheron²,

Mathis³

et al. 2010

Eur Neurol

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“…Beside genetic factors, RLS in prior pregnancies or RLS in the past without pregnancy, are also important risk factors for RLS during pregnancy [15,18] since only 55.4% in a previous study [20] had de novo RLS during the index pregnancy. This effect also occurs later in life many years after the pregnancy [28] since, as in our study, RLS seems to be more frequent and more severe among women with previous pregnancies who had a higher mean IRLS score than women without children [29]. This could suggest that one pregnancy alone is enough to create a long-lasting alteration in biological factors later leading to RLS [28].…”

Section: Discussionsupporting

confidence: 53%

Restless Legs Syndrome and Pregnancy: Follow-Up of Pregnant Women before and after Delivery

et al. 2010

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Aims: To describe the frequency of restless legs syndrome (RLS) in a French population of randomly selected women during their third trimester of pregnancy and its evolution up to 3 months after delivery and to identify potential factors associated with the improvement of RLS after delivery. Methods: A cross-sectional questionnaire survey. Results: 186 pregnant women living in a French town were included. 32% of women were affected by RLS during the third trimester of their pregnancy. Multiple pregnancies and iron intake during pregnancy were significantly associated with RLS during the third trimester. RLS disappeared after delivery among 64.8% of the women, and by less than 2 weeks after delivery in half of them. This improvement after delivery was not associated with the number of previous pregnancies, the RLS severity and iron intake during pregnancy, peridural anaesthesia, caesarean section, delivery complications, newborn weight, breastfeeding, dopaminergic agent intake after delivery, and with the absence of RLS before pregnancy. Conclusions: RLS affects one third of pregnant women during their third trimester and usually improves after delivery. Although there is no allowed treatment, most of the time only counselling and iron status assessment should be provided.

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“…Although the data on patients' medications were available, we did not screen for comorbid diseases in migraine patients and controls, which could affect the prevalence of RLS. The impact of female sex hormones on RLS has been discussed, and as with migraine [52], RLS severity has been reported to increase during the menstrual period [53]. Further study is required to clarify the association between RLS, migraine, and the menstrual cycle.…”

Section: Discussionmentioning

confidence: 99%

Evaluation of contributing factors to restless legs syndrome in migraine patients

Suzuki

Miyamoto

et al. 2011

J Neurol

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Recent studies have provided evidence for a positive association between migraine and restless legs syndrome (RLS), although the exact mechanisms and contributing factors remain unclear. A cross-sectional, case-control study was conducted, including patients with migraine (n = 262) and headache-free control subjects (n = 163). Migraine was diagnosed according to International Classification of Headache Disorders II criteria. RLS diagnosis was made based on four essential criteria as described by the International Restless Legs Syndrome Study Group. All patients completed the Migraine Disability Assessment (MIDAS) questionnaire, Beck Depression Inventory (BDI)-II scores, Pittsburgh Sleep Quality Index (PSQI), and Epworth Sleepiness Scale (ESS). A total of 210 blood samples were collected to correlate various parameters with RLS. RLS frequency was significantly greater in patients with migraine than in controls (13.7 vs. 1.8%). Migraine patients with RLS had high scores for MIDAS, BDI-II, PSQI, and ESS compared with those without RLS. In addition, migraine patients with RLS had a high rate of smoking and RLS family history, as well as increased levels of serum phosphorus and urea nitrogen compared with those without RLS. However, there was no difference in serum iron and ferritin levels between the groups. In migraine patients, logistic regression analysis revealed that positive RLS family history, BDI-II, ESS, and serum phosphorus levels were significant RLS predictors. Our study confirmed a positive association between RLS and migraine. RLS comorbidity in migraine patients was associated with insomnia, daytime sleepiness, depressive symptoms, headache-related disability, and increased serum phosphorus levels. These findings may provide a better understanding of RLS pathogenesis in migraine.

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Perceived severity of restless legs syndrome across the female life cycle

Cited by 51 publications

References 28 publications

Restless Legs Syndrome and Pregnancy: A Questionnaire Study in the Poitiers District, France

Restless Legs Syndrome and Pregnancy: A Questionnaire Study in the Poitiers District, France

Restless Legs Syndrome and Pregnancy: Follow-Up of Pregnant Women before and after Delivery

Evaluation of contributing factors to restless legs syndrome in migraine patients

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