Perceived exertion at work in women with fibromyalgia: Explanatory factors and comparison with healthy women

Palstam, Annie; Larsson, Anette; Bjersing, Jan; Löfgren, Monika; Ernberg, Malin; Bilevičiūtė-Ljungar, Indrė; Ghafouri, Bijar; Sjörs, Anna; Larsson, Björn; Gerdle, Björn; Mannerkorpi, Kaisa

doi:10.2340/16501977-1843

Cited by 23 publications

(33 citation statements)

References 38 publications

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“…It was executed in 3 cities: Linköping, Stockholm and Gothenburg. A more detailed description can be found in previous publications (34).…”

Section: Recruitment Processmentioning

confidence: 99%

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Unaltered low nerve growth factor and high brain-derived neurotrophic factor levels in plasma from patients with fibromyalgia after a 15-week progressive resistance exercise

Jablochkova¹,

Bäckryd²,

Mannerkorpi³

et al. 2019

J Rehabil Med

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LAY ABSTRACTPatients with fibromyalgia have treatment-resistant chronic pain. More research is needed in order to understand how and why fibromyalgia develops. Neurotrophins, such as nerve growth factor and brain-derived neurotrophic factor, are involved in peripheral and central nervous system development of pain and hyperalgesia, but few studies have examined circulating nerve growth factor and brain-derived neurotrophic factor in fibromyalgia or have investigated whether exercise interventions affect the levels of these peptides. This study compared blood levels of nerve growth factor and brain-derived neurotrophic factor in fibromyalgia with those in healthy controls, and investigated the effect of exercise on these levels. Brain-derived neurotrophic factor levels were higher and levels of nerve growth factor were lower in fibromyalgia, compared with healthy controls. Clinical improvements were achieved following the exercise intervention, but the levels of brain-derived neurotrophic factor and nerve growth factor were not normalized.Background: The pathophysiology of fibromyalgia includes central and peripheral factors. Neurotro phins, such as nerve growth factor and brainderived neurotrophic factor, are involved in peripheral and central nervous system development of pain and hy peralgesia. Few studies have examined circulating nerve growth factor and brainderived neurotrophic factor in fibromyalgia or have investigated whether exercise interventions affect the levels of these pep tides. Objectives: To compare plasma levels of nerve growth factor and brainderived neurotrophic factor in fibromyalgia and in healthy controls, to investiga te correlations between levels of nerve growth fac tor, brainderived neurotrophic factor, and cytokines and clinical variables, and to investigate the effect of exercise on these levels. Subjects and methods: A total of 75 women with fibromyalgia participated in blood tests at baseline and after the 15week intervention, and 25 healthy controls participated at baseline. Patients were ran domized to a 15week progressive resistance exer cise intervention or a relaxation intervention. Results: Brainderived neurotrophic factor level was significantly higher (p < 0.001) and nerve growth factor level was significantly lower (p < 0.001) in fi bromyalgia than in healthy controls. Neither resis tance exercise nor relaxation interventions affec ted the levels of brainderived neurotrophic factor or nerve growth factor. No significant correlations were found between brainderived neurotrophic fac tor or nerve growth factor plasma levels in fibromy algia and cytokine levels or clinical variables. Conclusion: Changes in circulating nerve growth factor and brainderived neurotrophic factor levels may affect nociception/pain in fibromyalgia. Clinical improvements were achieved following the exercise intervention, but the levels of brainderived neuro trophic factor and nerve growth factor were not nor malized.

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“…It was executed in 3 cities: Linköping, Stockholm and Gothenburg. A more detailed description can be found in previous publications (34).…”

Section: Recruitment Processmentioning

confidence: 99%

“…Subjects were not allowed to participate in a rehabilitation programme within the past year or practice resistance exercise or relaxation therapy twice a week or more. Consuming analgesics, non-steroidal anti-inflammatory drugs (NSAID), or hypnotic drugs were not allowed for 48 h before examination (34).…”

Section: Recruitment Processmentioning

confidence: 99%

Unaltered low nerve growth factor and high brain-derived neurotrophic factor levels in plasma from patients with fibromyalgia after a 15-week progressive resistance exercise

Jablochkova¹,

Bäckryd²,

Mannerkorpi³

et al. 2019

J Rehabil Med

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“…Leg muscle strength was assessed us- Follow-up at 20 weeks ♦ Lost to follow-up (death) (n = 1) ♦ No medical exam due to illness but surveys completed by mail (n = 1) ing the sit to stand (STS) test, in which the number of complete rises from a chair performed in 60 seconds was recorded (30). Isometric elbow flexion force was assessed with an electronic dynamometer (31). The patients were seated in a standardized position without back support and with legs stretched out.…”

mentioning

confidence: 99%

Effects of Aerobic and Resistance Exercise in Older Adults With Rheumatoid Arthritis: A Randomized Controlled Trial

Lange

Kucharski

Svedlund

et al. 2018

Arthritis Care & Research

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“…Estos resultados son cónsonos con los encontrados en la literatura revisada que destacan que las personas con fibromialgia muestran dificultad para realizar tareas o actividades del trabajo que involucre manejar objetos pesados y permanecer en la misma postura por largos periodos (Henriksson et al, 2005). Todo el esfuerzo que estas realizan en el trabajo será más marcado que el esfuerzo que realizan las personas sanas (Palstam et al, 2014).…”

Section: Discussionunclassified

Fibromialgia en Trabajo: explorando su Impacto en el Desempeño Laboral

Centeno¹,

Moreno-Velázquez²,

Sánchez-Cardona³

2018

Rev. Interam. Psicol. Ocup.

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Perceived exertion at work in women with fibromyalgia: Explanatory factors and comparison with healthy women

Abstract: Women with fibromyalgia perceive an elevated exertion at work, which is associated with physical work-related factors and factors related to fear and anxiety.

Cited by 23 publications

References 38 publications

Unaltered low nerve growth factor and high brain-derived neurotrophic factor levels in plasma from patients with fibromyalgia after a 15-week progressive resistance exercise

Unaltered low nerve growth factor and high brain-derived neurotrophic factor levels in plasma from patients with fibromyalgia after a 15-week progressive resistance exercise

Effects of Aerobic and Resistance Exercise in Older Adults With Rheumatoid Arthritis: A Randomized Controlled Trial

Fibromialgia en Trabajo: explorando su Impacto en el Desempeño Laboral

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