Effects of Aerobic and Resistance Exercise in Older Adults With Rheumatoid Arthritis: A Randomized Controlled Trial

Lange, Elvira; Kucharski, D.; Svedlund, Sara; Svensson, Karin; Bertholds, Gunhild; Gjertsson, Inger; Mannerkorpi, Kaisa

doi:10.1002/acr.23589

Cited by 56 publications

(119 citation statements)

References 51 publications

(87 reference statements)

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“…This is a sub-study of a randomized controlled trial that evaluated the effect of 20 weeks moderate-to-high intensity exercise on older adults with RA [18]. The study participants were recruited from the Rheumatology clinics at the Sahlgrenska University Hospital, Gothenburg and Skaraborg Hospital, Skövde, Sweden, using the Swedish Rheumatology Quality Register (SRQ).…”

Section: Methodsmentioning

confidence: 99%

“…The active control group (n = 38) performed light home-based exercise for mobility, lower body strength and balance, but no gym-based exercise for 20 weeks. The exercise of both groups is described in detail elsewhere [18].…”

Section: Study Groupsmentioning

confidence: 99%

“…The medical assessment included physical examination, disease activity and blood samples. The flowchart of participant enrolment and follow-up, along with the details of tests of physical fitness, is presented elsewhere [18].…”

Section: Patientsmentioning

confidence: 99%

“…Inclusion criteria: RA according to the ACR 1987/ EULAR 2010 criteria; age ≥ 65 years; disease duration > 2 years; disease activity score 28 < 5.1. Exclusion criteria: co-morbidities such as unstable ischemic heart disease or arrhythmia that might preclude moderate intensity exercise; joint surgery within the 6 months prior to inclusion; ongoing exercise of moderate-to-high intensity ≥ 2 times/ week; inability to understand or speak Swedish; inability to participate in physical testing that involved walking or bicycling [18].…”

Section: Patientsmentioning

confidence: 99%

“…1). The exercise group (n = 36) and the active control group (n = 38) were considered equal in sociodemographic data [18]. All participants were invited to a post-treatment examination after 20 weeks and 100% (n = 36) in the exercise group and 97% (n = 37) in the active control group completed the test.…”

Section: Patientsmentioning

confidence: 99%

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Moderate-to-high intensity exercise with person-centered guidance influences fatigue in older adults with rheumatoid arthritis

et al. 2019

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Fatigue is described as a dominant and disturbing symptom of rheumatoid arthritis (RA) regardless of the advances in pharmacological treatment. Fatigue is also found to correlate with depression. The objective was to evaluate the impact of moderate-to-high intensity, aerobic and resistance exercise with person-centered guidance on fatigue, anxiety and depression, in older adults with RA. Comparisons were made between older adults (> 65 years) with RA taking part in a 20-week moderate-to-high intensity exercise at a gym (n = 36) or in home-based exercise of light intensity (n = 38). Assessments were performed at baseline, at 20 weeks, and at 52 weeks. Outcomes were differences in Multidimensional Fatigue Inventory (MFI-20), Visual Analog Scale Fatigue (VAS fatigue), and Hospital Anxiety and Depression Scale (HADS). Analysis of metabolomics was also performed. The subscales "physical fatigue" and "mental fatigue" in MFI-20 and symptoms of depression using HADS depression scale improved significantly at week 20 in the exercise group compared with the control group. Exercise did not influence global fatigue rated by VAS or subscales "reduced motivation", "reduced activity" and "general fatigue" in MFI-20. No significant change was found on the anxiety index of HADS. The improvements in physical fatigue were associated with changes in the metabolism of lipids, bile acids, the urea cycle and several sugars. Moderateto-high intensity exercise with person-centered guidance decreased fatigue and improved symptoms of depression and were accompanied by metabolic changes in older adults with RA.

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Section: Methodsmentioning

confidence: 99%

Section: Study Groupsmentioning

confidence: 99%

Section: Patientsmentioning

confidence: 99%

Section: Patientsmentioning

confidence: 99%

Section: Patientsmentioning

confidence: 99%

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Moderate-to-high intensity exercise with person-centered guidance influences fatigue in older adults with rheumatoid arthritis

et al. 2019

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General Functional Status: Common Outcome Measures for Adults With Rheumatic Disease

Lane

Givens

Thoma

2020

Arthritis Care & Research

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Remotely Supervised Weight Loss and Exercise Training to Improve Rheumatoid Arthritis Cardiovascular Risk: Rationale and Design of the Supervised Weight Loss Plus Exercise Training‐Rheumatoid Arthritis Trial

Andonian

Ross

Zidek

et al. 2023

ACR Open Rheumatology

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Patients with rheumatoid arthritis (RA) remain at an increased risk for cardiovascular disease (CVD) and mortality. RA CVD results from a combination of traditional risk factors and RA‐related systemic inflammation. One hypothetical means of improving overall RA CVD risk is through reduction of excess body weight and increased physical activity. Together, weight loss and physical activity can improve traditional cardiometabolic health through fat mass loss, while also improving skeletal muscle health. Additionally, disease‐related CVD risk may improve as both fat mass loss and exercise reduce systemic inflammation. To explore this hypothesis, 26 older persons with RA and overweight/obesity will be randomized to 16 weeks of a usual care control arm or to a remotely Supervised Weight Loss Plus Exercise Training (SWET) program. A caloric restriction diet (targeting 7% weight loss) will occur via a dietitian‐led intervention, with weekly weigh‐ins and group support sessions. Exercise training will consist of both aerobic training (150 minutes/week moderate‐to‐vigorous exercise) and resistance training (twice weekly). The SWET remote program will be delivered via a combination of video conference, the study YouTube channel, and study mobile applications. The primary cardiometabolic outcome is the metabolic syndrome Z score, calculated from blood pressure, waist circumference, high‐density lipoprotein cholesterol, triglycerides, and glucose. RA‐specific CVD risk will be assessed with measures of systemic inflammation, disease activity, patient‐reported outcomes, and immune cell function. The SWET‐RA trial will be the first to assess whether a remotely supervised, combined lifestyle intervention improves cardiometabolic health in an at‐risk population of older individuals with RA and overweight/obesity.

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Effects of Aerobic and Resistance Exercise in Older Adults With Rheumatoid Arthritis: A Randomized Controlled Trial

Abstract: Person-centered aerobic and resistance exercise improved physical fitness in terms of aerobic capacity, endurance and strength in older adults with RA. This article is protected by copyright. All rights reserved.

Cited by 56 publications

References 51 publications

Moderate-to-high intensity exercise with person-centered guidance influences fatigue in older adults with rheumatoid arthritis

Moderate-to-high intensity exercise with person-centered guidance influences fatigue in older adults with rheumatoid arthritis

General Functional Status: Common Outcome Measures for Adults With Rheumatic Disease

Remotely Supervised Weight Loss and Exercise Training to Improve Rheumatoid Arthritis Cardiovascular Risk: Rationale and Design of the Supervised Weight Loss Plus Exercise Training‐Rheumatoid Arthritis Trial

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