Peran prostaglandin pada pergerakan gigi ortodontik

Iskandar, Patricia; Ismaniati, Nia Ayu

doi:10.15562/jdmfs.v9i2.238

Cited by 2 publications

(2 citation statements)

References 4 publications

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“…The first messenger will then stimulate a second messenger release, including cAMP and intracellular calcium, which will then activate the osteoclast. In addition, prostaglandins binding to EP4 receptors on the surface of osteoblasts will trigger the formation of RANKL, if bound to RANK present on the surface of osteoclast progenitor cells, will activates osteoclasts to resorb bone, and some researchers have proved that prostaglandin administration may accelerate almost two fold of orthodontic tooth movement 18 .…”

Section: Discussionmentioning

confidence: 99%

Caffeine increases PGE2 levels at compression and tension areas during orthodontic tooth movement

2018

IJCTR

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Objective: To analyze the effect of caffeine on PGE2 levels during orthodontic tooth movement. Experimental: Sixteen healthy male rats were divided into two groups, i.e. control group (C) consisted of eight rats applied with orthodontic force (OF), and treatment group (T) consisted of eight rats applied with OF and caffeine 1.35 mg/100 g BW twice a day for 14 days. The rats were anesthetized using ketamine, and subsequently OF was applied. A ligature wire with a diameter of 0.20 mm was mounted by attaching on the maxillary right first molar and both of the maxillary incisors. Next, the maxillary right first molar was moved to mesial using a tension gauge to generate 10 g/cm2 by using nickel titanium orthodontic closed coil spring. The observations were carried out on the 8 th and 15 th days of study period, GCFs were taken by placing the paper points in the gingival sulcus of mesio-and disto-palatal permanent maxillary right first molar. PGE2 levels was determined by using ELISA. Results: caffeine on 8 th and 15 th days enhanced PGE2 levels on the compression and tension areas (p <0.05). PGE2 levels on the compression area were significantly greater compared to that in the tension area (p <0.05). Conclusion: Caffeine increased PGE2 levels during orthodontic tooth movement. Caffein can trigger osteoclast formation and increase the efficiency of tooth movement, thus it may enhance the effectiveness of orthodontic treatment in the future.

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Section: Discussionmentioning

confidence: 99%

Caffeine increases PGE2 levels at compression and tension areas during orthodontic tooth movement

2018

IJCTR

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“…Ketika tekanan diaplikasikan pada mahkota gigi, akan diteruskan melalui akar gigi ke ligamen periodontal dan tulang alveolar, dan akan menimbulkan daerah tekanan dan daerah regangan. 16 pada daerah tekanan, ekspresi RANK oleh osteoklas menyebabkan resorpsi yang dibutuhkan oleh pergerakan gigi, sedangkan daerah tarikan ekspresi OPG oleh osteoblas yang memblok ikatan RANK dan RANK-L dapat menghambat resorpsi dan mengaktivasi aposisi.…”

Section: Studi Pustakaunclassified

<p>Potensi gel Stichopus hermanii dan Hyperbaric Oxygen Therapy untuk mempercepat perawatan ortodonti</p><p>Potential of Stichopus hermanii gel and Hyperbaric Oxygen Therapy in accelerating orthodontic treatment</p>

Sandana

Velisia

Yunior

et al. 2017

JKG

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Perawatan ortodonti memerlukan inovasi untuk mempercepat waktu perawatan. Perawatan ortodonti menyebabkan adanya daerah tekanan dan tarikan yang dipengaruhi oleh ekspresi Receptor Activator of Nuclear Factor Kappa β (RANK) pada daerah tekanan, yang merangsang osteoklas dan ekspresi osteoprotegerin pada daerah tarikan yang merangsang osteoblast. Stichopus hermanii mempunyai efek pada proses penyembuhan, Hyperbaric Oxygen Therapy (HBOT) memberikan efek remodelling. Studi pustaka ini bertujuan untuk mengungkapkan mekanisme potensi gel Stichopus hermanii dan Hyperbaric Oxygen Therapy (HBOT) dalam mempercepat proses pergerakan gigi pada perawatan ortodonti sebagai alternatif terapi. Studi Pustaka: Inovasi untuk mempercepat perawatan ortodonti dilakukan pada daerah tekanan dan tarikan. Pemberian gel Stichopus hermanii secara lokal dapat meningkatkan level osteoprotegerin yang menghambat ikatan antara Receptor Activator of Nuclear Factor Kappa-β Ligand (RANK-L) dan Receptor Activator of Nuclear Factor Kappa β (RANK), sehingga menghambat aktivasi osteoklas dan mengaktivasi aposisi tulang. Hyperbaric Oxygen Therapy menstimulasi ekspresi RANK pada daerah tekanan membantu mempercepat proses resorpsi. Kombinasi gel Stichopus hermanii dan Hyperbaric Oxygen Therapy menyebabkan pergerakan gigi meningkat melalui proses remodelling. Simpulan: Inovasi kombinasi terapi gel Stichopus hermanii dan Hyperbaric Oxygen Therapy dapat meningkatkan pergerakan gigi pada perawatan ortodonti.

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Peran prostaglandin pada pergerakan gigi ortodontik

Cited by 2 publications

References 4 publications

Caffeine increases PGE2 levels at compression and tension areas during orthodontic tooth movement

Caffeine increases PGE2 levels at compression and tension areas during orthodontic tooth movement

<p>Potensi gel Stichopus hermanii dan Hyperbaric Oxygen Therapy untuk mempercepat perawatan ortodonti</p><p>Potential of Stichopus hermanii gel and Hyperbaric Oxygen Therapy in accelerating orthodontic treatment</p>

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