Per-follicle measurements indicate that anti-müllerian hormone secretion is modulated by the extent of follicular development and luteinization and may reflect qualitatively the ovarian follicular status

Follicular fluid anti-Müllerian hormone and inhibin B concentrations: comparison between gonadotropin-releasing hormone (GnRH) agonist and GnRH antagonist cycles

“…In addition, we found a strong correlation between serum and FF AMH levels, which means that serum AMH reflects intrafollicular AMH secretion as well as the number of follicles. There has been only one previous study on the relation between FF AMH level and COH outcomes (24), which showed that FF AMH levels were significantly correlated with numbers of mature follicles and oocytes retrieved. Our results are in line with those of the previous study and confirm the qualitative roles of serum AMH and a role of AMH in folliculogenesis.…”

“…It is possible that comparative study of FF markers between GnRH-a and GnRH antagonist cycles for COH would reveal differences in the follicular microenvironment for these two protocols and would help clarify this issue. There have been several studies of FF AMH or inhibin B concentrations (22)(23)(24); however, to the best of our knowledge, there have been no comparative studies on FF AMH and inhibin B concentrations between GnRH-a and GnRH antagonist cycles for COH.…”

Association of anti-mullerian hormone levels with obesity in late reproductive-age women

“…In postnatal females, AMH is secreted by the primary, secondary and antral follicles and appears to regulate early follicular development (1,2). The exact role of AMH in the ovary is not entirely clear, but the proposed functions include inhibition of follicular recruitment, inhibition of aromatase activity, and reduced sensitivity of follicles to FSH (3,4).…”

Serum and ovarian Müllerian inhibiting substance, and their decline in reproductive aging

“…A number of investigators presented data to support the hypothesis that MIS could be used as a biomarker of ovarian age and ovarian reserve in humans (17)(18)(19)(20)(21)(22)(23)(24)(25)(26)(27). In humans, findings showed [1] that serum MIS levels decline with increasing reproductive age, [2] that after oophorectomy there is a precipitate drop in levels of MIS, [3] that after gonadotropin stimulation for assisted reproductive technologies, the levels of MIS decline, and [4] that the follicular-fluid MIS levels differ between younger patients and older patients (17)(18)(19)(20)(21)(22)(23)(24)(25)(26)(27)(28). Kevenaar et al measured serum MIS in mice, and the decline in MIS levels found in aging mice is consistent with the results obtained in humans (29).…”

“…In human studies by de Vet et al (17) and Fanchin et al (19), as subsequently reviewed by Visser et al (36), a correlation was observed between serum MIS levels and the antral follicle count as determined by ultrasonography. Further, Fanchin et al (26) showed a correlation between the ultrasonographically defined small follicle count and the serum MIS level, and concluded that the serum MIS level may reflect per-follicle MIS follicle production. The findings reported in this study extend the previous studies, and show histologically that it is the total number of small follicles that are MIS-positive that is related to the serum MIS level.…”