2000
DOI: 10.1128/iai.68.7.3965-3970.2000
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Peptidoglycan and Lipoteichoic Acid fromStaphylococcus aureusInduce Tumor Necrosis Factor Alpha, Interleukin 6 (IL-6), and IL-10 Production in Both T Cells and Monocytes in a Human Whole Blood Model

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Cited by 176 publications
(143 citation statements)
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“…TLR2 expression on T cells has been observed (23), and both direct and indirect T cell costimulatory properties have been ascribed to TLR2 agonists (24,25). In addition, it has been shown in vitro that TLR2 agonists alone are able to activate T cells (26). Similar observations were reported for the TLR4 agonist LPS (27,28).…”
Section: Discussionsupporting
confidence: 59%
“…TLR2 expression on T cells has been observed (23), and both direct and indirect T cell costimulatory properties have been ascribed to TLR2 agonists (24,25). In addition, it has been shown in vitro that TLR2 agonists alone are able to activate T cells (26). Similar observations were reported for the TLR4 agonist LPS (27,28).…”
Section: Discussionsupporting
confidence: 59%
“…TNF-␣, INF-␥, IL-1␤, IL-6) and iNOS in myeloid cells that are key contributors to the sepsis syndrome. In keeping with these observations, studies using a human whole blood model indicated that lipoteichoic acid can induce expression of TNF-␣, IL-6, and IL-10 in a time-and dose-dependent manner (15). Collectively, these studies indicate that precise molecular mechanisms mediate the effects of Gram-positive bacterial endotoxins that contribute to the systemic inflammatory response syndrome.…”
mentioning
confidence: 51%
“…The most evident consequence of TLR stimulation is the induction of the inflammatory response. TLR ligation results in the production of pro-and anti-inflammatory cytokines (IL-1, IL-6, IL-8, IL-10, TNFα) [40][41][42], chemokines (IL-8, MCP-1) [43,44], defensins [45], and antiviral type-I interferons [46,47]. Other mechanisms attributed to TLR signaling are processes including apoptosis, tissue repair and angiogenesis.…”
Section: The Results Of Tlr Activation -Tlrs In Carcinogenesismentioning
confidence: 99%