Peptidoglycan and Bacterial DNA Induce Inflammation and Coagulation Markers in Synergy

Amoureux, Marie Claude; Rajapakse, Nandani; Stipkovits, L.; Szathmáry, Susan

doi:10.1155/mi.2005.118

Cited by 9 publications

(8 citation statements)

References 16 publications

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“…They are key players in infectious diseases and implicate toll-like receptors (TLR) in the activation of inflammation[1]. …”

Section: Introductionmentioning

confidence: 99%

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Urinary tract infections caused by staphylococcus aureus DNA in comparison to the candida albicans DNA

Al-Mathkhury¹,

Abdul-Ghaffar²

2011

North Am J Med Sci

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Background:Bacterial DNA released upon bacterial autolysis or killed by antibiotics, hence, many inflammatogenic reactions will be established leading to serious tissue damage.Aim:the present work aimed to elucidate the histopathological changes caused by prokaryotic (bacterial) DNA and eukaryotic (candidal) DNA.Materials and Methods:twenty one Staphylococcus aureus and 36 Candida albicans isolates were isolated from UTI patients. Viable cells and DNA of the highest antibiotic sensitive isolates were injected, intraurethraly, in mice. Results were evaluated via histopathological examination.Results:Mildest reactions were obtained from mice challenged with viable C. albicans compared with those challenged with viable S. aureus. Dose-dependent histological changes were observed for both eukaryotic and prokaryotic DNA. However, the eukaryotic C. albicans DNA developed less intense histological changes than S. aureus DNA.Conclusion:microbial DNA has the ability to cause damage in murine renal system. Nevertheless, bacterial DNA caused more intense damage than candidal DNA.

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“…They are key players in infectious diseases and implicate toll-like receptors (TLR) in the activation of inflammation[1]. …”

Section: Introductionmentioning

confidence: 99%

“…Microbial components signal the presence of foreign pathogens in the innate immune system. They are key players in infectious diseases and implicate toll-like receptors (TLR) in the activation of inflammation[ 1 ].…”

Section: Introductionmentioning

confidence: 99%

Urinary tract infections caused by staphylococcus aureus DNA in comparison to the candida albicans DNA

Al-Mathkhury¹,

Abdul-Ghaffar²

2011

North Am J Med Sci

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“…It is well known that living periodontal pathogens can invade and destroy host tissues 33 , 34 . It also described that bacterial compounds like lipopolysaccharide (LPS), bacterial DNA and certain bacterial proteins can induce an inflammatory reaction 35 , 36 . However, the influence of dead bacteria (necrotoxicity) alone or in combination with living bacteria on the host tissues has never been shown.…”

Section: Discussionmentioning

confidence: 99%

Necrotrophic growth of periodontopathogens is a novel virulence factor in oral biofilms

Herrero

Boon

Pauwels

et al. 2017

Sci Rep

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The oral use of antimicrobial agents embedded in toothpastes and mouth rinses results in an oral microbial massacre with high amounts of dead bacteria in close proximity to few surviving bacteria. It was hypothesized that this provides the surviving pathogenic bacteria a large amount of dead microbial biomass as a nutritional source for growth (necrotrophy). This study demonstrated the necrotrophic growth of periodontal pathogens in the presence of different dead oral species. In addition, the presence of dead bacteria resulted in an outgrowth of several periodontal pathogens in complex multi-species biofilms. Additionally, upon contact with dead oral bacteria, virulence genes of P. intermedia and P. gingivalis were up-regulated (necrovirulence). This resulted in a more pronounced epithelial cytotoxicity (necrotoxicity). These findings indicate that presence of dead bacteria induce necrotrophy, necrovirulence and necrotoxicity in several oral pathogens.

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“…DNA is capable of synergising with sub‐stimulatory levels of LPS and with peptidoglycan to upregulate pro‐inflammatory mediators in in vitro and animal model systems . The presence of microbial DNA from ‘good bacteria’ found in probiotics has also been associated with an anti‐inflammatory response .…”

Section: Methodological Considerations In the Reproductive Tract Micrmentioning

confidence: 99%

Re‐assessing microbiomes in the low‐biomass reproductive niche

Turner

Nitert

et al. 2019

BJOG

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The female reproductive tract represents a continuum between the vagina and the upper genital tract. New evidence from cultivation‐independent studies suggests that the female upper genital tract is not sterile; however, the significance of this for reproductive health and disease remains to be elucidated fully. Further, diagnosis and treatment of infectious reproductive tract pathologies using cultivation‐independent technologies represents a largely unchartered area of modern medical science. The challenge now is to design well‐controlled experiments to account for the ease of contamination known to confound molecular‐based studies of low‐biomass niches, including the uterus and placenta. This will support robust assessment of the potential function of microorganisms, microbial metabolites, and cell‐free bacterial DNA on reproductive function in health and disease. Tweetable abstract Molecular microbial studies of low‐biomass niches require stringent experimental controls to reveal causal relations in reproductive health and disease.

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Peptidoglycan and Bacterial DNA Induce Inflammation and Coagulation Markers in Synergy

Cited by 9 publications

References 16 publications

Urinary tract infections caused by staphylococcus aureus DNA in comparison to the candida albicans DNA

Urinary tract infections caused by staphylococcus aureus DNA in comparison to the candida albicans DNA

Necrotrophic growth of periodontopathogens is a novel virulence factor in oral biofilms

Re‐assessing microbiomes in the low‐biomass reproductive niche

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