“…In particular, IAV-derived DIPs resulted in a high tolerability and antiviral efficacy in animal studies [5,16,[18][19][20][21][22][23][24][25], and were therefore proposed as prophylactic and therapeutic antivirals [16,[25][26][27]. IAV DIPs typically contain a large internal deletion in one of the eight genomic viral RNA (vRNA) segments [4,10,16,22,25,26,[28][29][30].…”