Generation of “OP7 chimera” defective interfering particle preparations free of infectious influenza A virus that shows antiviral efficacy in mice
Tanya Dogra,
Lars Pelz,
Julia D. Boehme
et al.
Abstract:Influenza A virus (IAV) defective interfering particles (DIPs) are considered as new promising antiviral agents. Conventional DIPs (cDIPs) contain a deletion in the genome and can only replicate upon co-infection with infectious standard virus (STV), during which they suppress STV replication. We previously discovered a new type of IAV DIP OP7 that entails genomic point mutations and displays higher antiviral efficacy than cDIPs. To avoid safety concerns for the medical use of OP7 preparations, we developed a … Show more
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