Peptides with anticancer use or potential

Abstract

This review is an attempt to illustrate the diversity of peptides reported for a potential or an established use in cancer therapy. With 612 references, this work aims at covering the patents and publications up to year 2000 with many inroads in years 2001-2002. The peptides are classed according to four categories of effective (or plausible) biological mechanisms of action: receptor-interacting compounds; inhibitors of protein-protein interaction; enzymes inhibitors; nucleic acid-interacting compounds. The fifth group is made of the peptides for which no mechanism of action has been found yet. Incidentally this work provides an overview of many of the modern targets of anticancer research.

A missense mutation in Caenorhabditis elegans prohibitin 2 confers an atypical multidrug resistance

“…CB4856 males were mated with triple mutants and, from the F 2 generation, recombinant Bli-nonRol worms were selected, made homozygous, and tested for the compound 3-sensitive or -resistant genotype. After SNP analysis of isolated recombinants, the mutation was mapped between snp uCE2-1658 and snp C29F5 [1]. Mating with two strains, mnDf30 and mnDf96, each having a deficiency spanning the region, confirmed the location of the mutation.…”

“…We amplified all 65.7 kb of genomic DNA from the phb-2(ad2154) mutant from snp uCE2-1658 to snp C29F5 [1] and sequenced the PCR products. We identified the only mutation present in that region in the T24H7.1 (phb-2) gene.…”

“…Hemiasterlin is one of the naturally occurring toxins found to act on tubulin (1). Hemiasterlin poisons spindle assembly in cultured cells, leading to growth arrest in mitosis (2).…”

A new cytotoxic indole-3-ethenamide from the halotolerant fungus Aspergillus sclerotiorum PT06-1

“…6 Meanwhile, because of many of small peptides possessing a potential or an established use in cancer therapy, these compounds have intrigued us. 7 Our previous work revealed two novel cyclic hexapeptides, 8 and 11 new aspochracin-type cyclic tripeptides 9 from the metabolites of marine-derived halotolerant fungus Aspergillus sclerotiorum PT06-1 in hypersaline nutrient-limited and nutrient-rich media, respectively. Further chemical study led to the identification of a new indole-3-ethenamide (1), along with two known compounds, 7-(3-methylbut-2-enyl)-1H-indole-3-carbaldehyde (2) 10 and emodin (3) 11 from the ethyl acetate extract of the fermentation broth of A. sclerotiorum PT06-1 in a hypersaline nutrient-rich medium.…”

Psyllium Mucilage and Its Use in Pharmaceutical Field: An Overview

“…Rajasthan also has similar status for cultivation and production as the environmental conditions are very conducive for harvesting of these crops. Gujarat and Rajasthan are collectively reported to have an area of about 61,000 hectares under its cultivation [10,11]. India provides main contribution for availability of the psyllium in the world market and USA being the world's largest importer of psyllium husk.…”