Peptides of the neurointermediary lobe of rat pituitary stimulate GH secretion in vitro

Schlegel, Werner; Vecsey, A; Eberle, Alex E.; Chrétien, Michel; Seidah, Nabil G.; Zahnd, G

doi:10.1016/0303-7207(83)90097-7

Cited by 3 publications

(2 citation statements)

References 17 publications

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“…Interestingly, this a-MSH inhibitor has been previously described in the literature as a growth hormone-releasing peptide in vitro and in vivo (Bowers et al, 1984). Furthermore, it is known that a-MSH peptides possess weak growth hormone-releasing properties (Schlegel et al, 1983). Thus, the exact interrelationship of a-MSH and its analogs on pituitary function as related to growth hormone secretion remains unclear.…”

Section: A-msh Antagonist Analoguesmentioning

confidence: 99%

“…In fact, the excess secretion of ACTH, as in Addison's disease, can result in the hyperpigmentation of human skin, because of the intrinsic melanotropic activity of this peptide (Hadley, 1984). Finally, it is not known whether any physiological processes are controlled by 0-MSH or y-MSH, two other POMC-derived members of the so-called melanocortin de Wied and Jolles, 1982;Gispen et al, 1975;Hadley, 1984;Hadley et al, 1986;Hruby et al, 1984;Kokobun et al, 1983;Murphy et al, 1983;O'Donohue and Dorsa, 1982;Schlegel et al, 1983;Strand and Smith, 1980;Tatro and Reichlin, 1987;van Nispen and Greven, 1982). However, a definitive evaluation of the specificity of these biological effects has not included comparative structure-activity analysis, radioreceptor testing, or inhibition by the use of a n a-MSH antagonist.…”

Section: Introductionmentioning

confidence: 99%

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α‐Melanocyte‐stimulating hormone structure‐activity studies: Comparative analysis of melanotropic and CNS bioactivities

Sawyer¹,

Hadley

Hruby

et al. 1988

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The structure-activity relationships in vitro of alpha-MSH (alpha-melanocyte-stimulating hormone, alpha-melanotropin) analogs as determined on normal and transformed (melanoma cell) melanocyte bioassays are summarized. Specifically, the characterization of potent and metabolically stable melanotropic agonist analogs and a newly discovered antagonist of alpha-MSH are highlighted. Comparison of these data versus the known structure-activity relationships of alpha-MSH related to CNS bioactivities suggests the existence of nonclassical alpha-MSH receptor-mediated pathways or, perhaps, a yet undefined endogenous neuropeptidergic pathway(s) having different selectivities for alpha-MSH analogs. In summary, several of the alpha-MSH analogs reported here may be useful molecular probes in future strategies aimed at the identification and systematic characterization of both peripheral and central alpha-MSH receptors.

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Section: A-msh Antagonist Analoguesmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

α‐Melanocyte‐stimulating hormone structure‐activity studies: Comparative analysis of melanotropic and CNS bioactivities

Sawyer¹,

Hadley

Hruby

et al. 1988

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Prolactin and Growth Hormone Secretion in Stress

Reichlin

1988

Advances in Experimental Medicine and Biology

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ACTH 1–17 stimulates GH pituitary secretion in humans

Valenti

Banchini

Denti

et al. 1986

J Endocrinol Invest

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Nineteen normal subjects (12 men and 7 women) were injected with 100 micrograms of ACTH 1-17. Additionally 6 male subjects were studied twice at 3-day intervals with random infusions of ACTH 1-17 and saline. A clear GH response to ACTH 1-17 infusions (GH peak higher than 5 ng/ml) was documented in 10 out of 12 males and in 6 out of 7 women. In the 6 male subjects studied twice, clear-cut GH increments were observed only after peptide administration. PRL levels decreased throughout the study period both in male and female subjects; however, when the PRL percentage decline was evaluated in the same group of subjects after saline and ACTH 1-17, the more obvious decrease of PRL levels after the peptide infusion was not statistically significant. No variation of LH, FSH and TSH levels was documented. With the exception of the specific increase of cortisol levels, no significant change in peripheral steroid pattern (Te, E2, DHEA-S) was observed. In this experiment the effect on GH secretion was quite evident in both sexes. This effect was obtained using the lowest dosage of ACTH preparation documented in the literature.

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Peptides of the neurointermediary lobe of rat pituitary stimulate GH secretion in vitro

Cited by 3 publications

References 17 publications

α‐Melanocyte‐stimulating hormone structure‐activity studies: Comparative analysis of melanotropic and CNS bioactivities

α‐Melanocyte‐stimulating hormone structure‐activity studies: Comparative analysis of melanotropic and CNS bioactivities

Prolactin and Growth Hormone Secretion in Stress

ACTH 1–17 stimulates GH pituitary secretion in humans

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