Prolactin and Growth Hormone Secretion in Stress

Reichlin, Seymour

doi:10.1007/978-1-4899-2064-5_28

Cited by 17 publications

(6 citation statements)

References 87 publications

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“…By inhibiting phosphodiesterase, caffeine may decrease clearance of cAMP and enhance steroid production (Leonard et al, 1987). Moreover, in high doses, caffeine can induce stress-like effects in the pituitaryadrenal axis (Spiller, 1998), which could raise risk of uterine leiomyomata via increased secretion of prolactin (Reichlin, 1988;Mora et al, 1995;Andersen, 1996).…”

Section: Risk Factors For Uterine Leiomyomata In Black Womenmentioning

confidence: 99%

Risk of uterine leiomyomata in relation to tobacco, alcohol and caffeine consumption in the Black Women's Health Study

Wise

Palmer

Harlow³

et al. 2004

Human Reproduction

116

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BACKGROUND: Tobacco, alcohol and caffeine consumption may influence risk of uterine leiomyomata via changes in ovarian function or hormone metabolism. METHODS: We prospectively assessed the relation of these exposures to risk of self-reported uterine leiomyomata in the Black Women's Health Study. From 1997 to 2001, we followed 21 885 premenopausal women with intact uteri and no prior myoma diagnosis. Cox regression models were used to estimate incidence rate ratios (IRRs) and 95% confidence intervals (CIs). RESULTS: During 73 426 person-years of follow-up, 2177 incident cases of uterine leiomyomata confirmed by ultrasound (n 5 1920) or hysterectomy (n 5 257) were reported. Cigarette smoking was not associated with risk of uterine leiomyomata. Risk was positively associated with years of alcohol consumption and current consumption of alcohol, particularly beer. Relative to non-drinkers, multivariate IRRs for beer consumption of <1, 1 -6 and 71 drinks/week were 1.11 (95% CI 0.98-1.27), 1.18 (95% CI 1.00-1.40) and 1.57 (95% CI 1.17-2.11), respectively. Heavy coffee and caffeine consumption were not associated with risk overall, but IRRs were increased among women aged <35 years. CON-CLUSIONS: In US black women, risk of uterine leiomyomata was positively associated with current consumption of alcohol, particularly beer. Cigarette smoking and caffeine consumption were unrelated to risk overall.

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Section: Risk Factors For Uterine Leiomyomata In Black Womenmentioning

confidence: 99%

Risk of uterine leiomyomata in relation to tobacco, alcohol and caffeine consumption in the Black Women's Health Study

Wise

Palmer

Harlow³

et al. 2004

Human Reproduction

116

View full text Add to dashboard Cite

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“…Although inhibition of the PRL increase after exposure to ether was possible within 7 days, the coitus-induced surges apparently were not blocked in the first seven days after grafting. A more prolonged exposure to enhanced DA may be necessary to block the coitus-induced surges of PRL as they rely on different PRF from the ether response (25,26) and probably also require quantitatively different levels of DA withdrawal.…”

Section: Discussionmentioning

confidence: 97%

Intrahypothalamic Pituitary Grafts Elevate Prolactin in the Cerebrospinal Fluid and Attenuate Prolactin Release following Ether Stress

Grattan

Averill

1991

Experimental Biology and Medicine

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Anterior pituitary (AP) tissue grafted into the hypothalamus of female rats inhibits the luteotrophic prolactin (PRL) secretion which normally follows mating. Dopamine blockade has been shown to overcome this inhibition, suggesting that the grafts suppress PRL release from the in situ pituitary by the action of graft PRL increasing dopamine activity in the hypothalamus. To examine whether PRL levels in the cerebrospinal fluid (CSF) were elevated by the AP grafts, CSF samples were taken from 5 control rats and 10 rats bearing intrahypothalamic AP grafts. Mean PRL concentrations in the CSF of the control rats were 3.0 +/- 0.8 ng/ml. The grafted rats had significantly higher concentrations of PRL in their CSF, averaging 23.2 +/- 4.2 ng/ml (P less than 0.005). Plasma PRL concentrations were similar in the control and grafted rats. PRL release in response to 5 min of ether stress was examined in 8 control and 11 grafted rats. In control animals, PRL rose from 4.2 +/- 1.5 to 44.7 +/- 9.0 ng/ml following exposure to ether, but the response was significantly attenuated in the grafted rats, peaking at 9.3 +/- 1.4 ng/ml (P less than 0.001). This inhibition of response due to the grafts was evident within 1 week of graft placement. The results confirm that the presence of intrahypothalamic AP grafts led to the accumulation of supranormal PRL concentrations in the CSF. This elevated PRL suppressed pituitary PRL release in response to ether stress, probably by an autoregulatory feedback activation of the inhibitory tuberoinfundibular dopaminergic neurons in the hypothalamus.

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“…Therefore, the effect of dehydration on basal prolactin secretion may involve some enhancement of dopaminergic inhibition and this too could be due to a central action of vasopressin, as suggested in the rat (DePaolo, Berardo & Carrillo, 1986). Furthermore, the presence of magnocellular vasopressinergic axons in the ovine median eminence (Parry & Livett, 1973), where the inhibitory dopaminergic terminals are also located (Reichlin, 1988), indicates a pathway whereby the further suppression of basal prolactin secretion might be achieved.…”

Section: Discussionmentioning

confidence: 99%

“…The inability of exogenous CRF to influence prolactin secretion in dehydrated sheep confirms and extends previous findings in euhydrated 8 CRF, 30,ug animals (Donald et al 1983) and suggests that the enhanced stress response is not due to a pituitary action of CRF. The release of prolactin during stress may involve the removal of dopaminergic inhibition and/or the secretion of a prolactin-releasing factor (PRF; Reichlin, 1988). There is in vivo evidence that a small neurohypophysial peptide may function as a PRF in the rat (Hyde & Ben-Jonathan, 1989).…”

Section: Discussionmentioning

confidence: 99%

Prolactin secretion in sheep after dehydration followed by restraint or administration of ovine corticotrophin‐releasing factor

Matthews

Parrott²

1992

Experimental Physiology

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SUMMARYPlasma concentrations of prolactin werc measured in male sheep (wethers, n = 8) during 120 min exposure to mild physical stress (restraint), and also following i.v. injection of 30 lmg ovine corticotrophin-releasing factor (CRF), when the animals were water replete and when they had been deprived of water for 48 h. Restraint stress produced a small increase in prolactin secretion (n.s.) when the animals were euhydrated and a large increase (P < 0-001) when they were dehydrated. Administration of CRF had no effect on prolactin concentrations in either experimental condition. In a further study in which euhydrated animals (n = 6) were subjected to restraint while receiving infusions of vasopressin (I pg/h), there was no enhancement of basal or stress-induced prolactin secrction. Thus, dehydration enhances stress-induced prolactin release in sheep through a process that does not involve a pituitary action of CRF or circulating vasoprcssin.

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Prolactin and Growth Hormone Secretion in Stress

Cited by 17 publications

References 87 publications

Risk of uterine leiomyomata in relation to tobacco, alcohol and caffeine consumption in the Black Women's Health Study

Risk of uterine leiomyomata in relation to tobacco, alcohol and caffeine consumption in the Black Women's Health Study

Intrahypothalamic Pituitary Grafts Elevate Prolactin in the Cerebrospinal Fluid and Attenuate Prolactin Release following Ether Stress

Prolactin secretion in sheep after dehydration followed by restraint or administration of ovine corticotrophin‐releasing factor

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