Peptides from the calcitonin genes: molecular genetics, structure and function

Paracrine Regulation of Thyroid-Hormone Synthesis by C Cells

“…In contrast to calcitonin receptors found in bone, these receptors are not linked to adenylate cyclase, however, CGRP stimulates adenylate cyclase activity by acting at the calcitonin receptor in more than one tissue. Furthermore, specific cAMP linked CGRP receptors have been identified both in the intima and media of vessels as well as the atria and ventricles of the heart [80]. Seifert et al [81] demonstrated the presence of a novel specific receptor for CGRP in the acinar cells of the pancreas.…”

The action of CGRP and SP on cultured skin fibroblasts

“…CGRP is a 37-amino acid peptide expressed by neurons and endocrine cells in different tissues [11]. Two isoforms of the CGRP peptide have been described: alpha-CGRP, which is formed by the alternative mRNA splicing of the calcitonin gene located on chromosome 11; and beta-CGRP, which is encoded by a different, but closely related gene [11][12][13][14][15][16][17]. Alpha-CGRP and beta-CGRP differ from each other by three amino acids in humans and by one amino acid in rats [13,15], and exhibit overlapping biological actions [16].…”

Biotinyl analogues of amylin as biologically active probes for amylin/CGRP receptor recognition

“…Receptors for CGRP have been identified on a number of cell lines and tissues which are often of vascular origin, consistent with the role of CGRP as a potent vasodilator [6]. High affinity CGRP receptors have also been localized to the major sites of glucose metabolism, the liver [7,8] and skeletal muscle [8,9].…”