Peptidergic Systems

Schotman, P.; Schrama, Loes H.; Edwards, P.M.

doi:10.1007/978-1-4684-7018-5_11

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2000

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“…Other compounds, such as K ions and many regulatory peptides, act in the same manner [22,24]. Another mechanism is also possible: an increase in mediator secretion induced by some factor could induce (or enhance) the production of an inhibitory factor.…”

Section: Discussionmentioning

confidence: 99%

The modulating effects of various muscle factors on the function of motor nerve terminals

Drabkina

Matyushkin

Romanovskii

2000

Neurosci Behav Physiol

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Studies reported here showed that the incubation medium used for frog muscle contains factors able to modulate the secretion of mediator from motor nerve terminals, with increases in release from low-efficiency synapses and decreases in release from high-efficiency synapses. Both the stimulatory and the inhibitory effects of the incubation medium are mediated by the corresponding changes in the number of available mediator quanta stored. Factors with stimulatory presynaptic actions were present mainly in the low-molecular-weight (<10 kDal) fraction of the incubation medium. The extent of the stimulatory action of this fraction on low-efficiency synapses correlated with the concentration of histidine-containing substances.

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Section: Discussionmentioning

confidence: 99%