Peptide Vaccines for Malaria

Bermúdez, Adriana; Lozano, José Manuel; Patarroyo, Manuel E.

doi:10.1016/b978-012369442-3/50077-5

Cited by 6 publications

(4 citation statements)

References 86 publications

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“…For each challenge strain, the average body weight and survival percentages were analyzed (Figure 6). In the IN group, mice vaccinated with M2e NCs + CpG exhibited some weight loss ■ DISCUSSION Short peptide epitopes are potential antigens for developing vaccines against cancer, 26,27 infectious diseases such as influenza, 28 HIV, 29 malaria, 30 and even autoimmune diseases. 31 However, the small peptide epitopes are poorly immunogenic and require strategies to enhance their immunogenicity.…”

Section: ■ Resultsmentioning

confidence: 99%

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Generation of Broad Protection against Influenza with Di-Tyrosine-Cross-Linked M2e Nanoclusters

Wilks,

Joshi,

Rychener

et al. 2024

ACS Infect. Dis.

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Tyrosine cross-linking has recently been used to produce nanoclusters (NCs) from peptides to enhance their immunogenicity. In this study, NCs were generated using the ectodomain of the ion channel Matrix 2 (M2e) protein, a conserved influenza surface antigen. The NCs were administered via intranasal (IN) or intramuscular (IM) routes in a mouse model in a prime-boost regimen in the presence of the adjuvant CpG. After boost, a significant increase in anti-M2e IgG and its subtypes was observed in the serum and lungs of mice vaccinated through the IM and IN routes; however, significant enhancement in anti-M2e IgA in lungs was observed only in the IN group. Analysis of cytokine concentrations in stimulated splenocyte cultures indicated a Th1/Th17-biased response. Mice were challenged with a lethal dose of A/California/07/2009 (H1N1pdm), A/Puerto Rico/08/1934 (H1N1), or A/Hong Kong/08/1968 (H3N2) strains. Mice that received M2e NCs + CpG were significantly protected against these strains and showed decreased lung viral titers compared with the naive mice and M2e NC-alone groups. The IN-vaccinated group showed superior protection against the H3N2 strain as compared to the IM group. This research extends our earlier efforts involving the tyrosine-based cross-linking method and highlights the potential of this technology in enhancing the immunogenicity of short peptide immunogens.

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Section: ■ Resultsmentioning

confidence: 99%

“…Short peptide epitopes are potential antigens for developing vaccines against cancer, , infectious diseases such as influenza, HIV, malaria, and even autoimmune diseases . However, the small peptide epitopes are poorly immunogenic and require strategies to enhance their immunogenicity.…”

Section: Discussionmentioning

confidence: 99%

Generation of Broad Protection against Influenza with Di-Tyrosine-Cross-Linked M2e Nanoclusters

Wilks,

Joshi,

Rychener

et al. 2024

ACS Infect. Dis.

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“…Beberapa perkembangan yang sangat konstruktif telah dicatat untuk memperkenalkan vaksin malaria berbasis peptida yang mampu menginduksi antibodi terhadap Plasmodium falciparum. Meskipun urutan peptida (Glu-Val-LeuTyr-Leu-Lys-Pro-Leu-Ala-Gly-Val-Tyr-Arg-Ser-Leu-Lys-Lys-Gln-Leu-Glu) berasal dari MSP-1, yang dilestarikan di semua galur parasit, tetapi keberhasilannya tetap dipertanyakan dan masih diperlukan lebih banyak pekerjaan untuk mengembangkan vaksin malaria karena P. falciparum sangat efektif untuk menghindari deteksi oleh sistem kekebalan melalui mekanisme yang berbeda (Lozano et al, 2006).…”

Section: Tantanganunclassified

Prospek Dan Perkembangan Bioteknologi Mikroba

Hafsan¹

2023

Preprint

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Mikroba sebagai agen bioteknologi secara khusus diulas pada buku ini berikut beberapa studi kasus terkait pemanfaatan mikroba yang diimplementasikan pada berbagai aspek kehidupan manusia. Pemahaman yang konkrit tentang konsep dasar proses-proses biologis mikroba dalam bioteknologi merupakan harapan terbesar yang diharapkan atas terbitnya buku ini sehingga dapat digunakan sebagai acuan untuk meningkatkan kompetensi diri dalam upaya mengimplementasikan wawasan kebioteknologian. Peran mikroba dalam pengembangan dan atau menghasilkan produk yang bermanfaat bagi kehidupan dalam bidang pertanian, Kesehatan dan pengolahan pangan menjadi fokus pembahasan buku ini.

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“…There are two strategies to develop phage-based vaccine: (1) Phage-based vaccine can mimic to display antigens on their coated protein surface, or (2) display peptide target to the antigen presenting cells and deliver DNA-encoded antigens. Phagebased vaccine has a potential for immunotherapy including cancer [413,414], malaria [415,416], and Alzheimer [417].…”

Section: Phage-based Vaccinesmentioning

confidence: 99%

Review: Development of SARS-CoV-2 immuno-enhanced COVID-19 vaccines with nano-platform

et al. 2021

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Vaccination is the most effective way to prevent coronavirus disease 2019 (COVID-19). Vaccine development approaches consist of viral vector vaccines, DNA vaccine, RNA vaccine, live attenuated virus, and recombinant proteins, which elicit a specific immune response. The use of nanoparticles displaying antigen is one of the alternative approaches to conventional vaccines. This is due to the fact that nano-based vaccines are stable, able to target, form images, and offer an opportunity to enhance the immune responses. The diameters of ultrafine nanoparticles are in the range of 1–100 nm. The application of nanotechnology on vaccine design provides precise fabrication of nanomaterials with desirable properties and ability to eliminate undesirable features. To be successful, nanomaterials must be uptaken into the cell, especially into the target and able to modulate cellular functions at the subcellular levels. The advantages of nano-based vaccines are the ability to protect a cargo such as RNA, DNA, protein, or synthesis substance and have enhanced stability in a broad range of pH, ambient temperatures, and humidity for long-term storage. Moreover, nano-based vaccines can be engineered to overcome biological barriers such as nonspecific distribution in order to elicit functions in antigen presenting cells. In this review, we will summarize on the developing COVID-19 vaccine strategies and how the nanotechnology can enhance antigen presentation and strong immunogenicity using advanced technology in nanocarrier to deliver antigens. The discussion about their safe, effective, and affordable vaccines to immunize against COVID-19 will be highlighted.

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Peptide Vaccines for Malaria

Cited by 6 publications

References 86 publications

Generation of Broad Protection against Influenza with Di-Tyrosine-Cross-Linked M2e Nanoclusters

Generation of Broad Protection against Influenza with Di-Tyrosine-Cross-Linked M2e Nanoclusters

Prospek Dan Perkembangan Bioteknologi Mikroba

Review: Development of SARS-CoV-2 immuno-enhanced COVID-19 vaccines with nano-platform

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