Peptide Screening from a Phage Display Library for Benzaldehyde Recognition

Tanaka, Masayoshi; Minamide, Taisuke; Takahashi, Yuta; Hanai, Yosuke; Yanagida, Takeshi; Okochi, Mina

doi:10.1246/cl.190318

Cited by 14 publications

(15 citation statements)

References 44 publications

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“…This made selection possible, even with weaker affinities [81]. However, Tanaka et al [82] recently managed to perform the highly sensitive detection of benzaldehyde in solution and in the gas phase with a peptide selected from a seven-mer commercial library. Nonetheless, they did not clearly demonstrate the selectivity of this peptide.…”

Section: Phage Displaymentioning

confidence: 99%

“…Indeed, in the work of Sawada et al [78], circular dichroism spectroscopy showed that the selected peptide folds in β-turn. For Tanaka et al [82], the best binders included a proline, which can contribute to a bent or twisted conformation. In both cases, the authors considered the structuration of the peptides was partly responsible for the molecular recognition.…”

Section: Improvement Of the Selectivitymentioning

confidence: 99%

“…Zine et al [104] generated them directly in situ. Recently, Tanaka et al [82] immobilized selective peptides on ZnO nanowires, Figure 7b.…”

Section: Increase Of the Sensitivitymentioning

confidence: 99%

“…(a) Olfactory neurons deploy a large specific surface area in the mucus through their cilia. To mimic this strategy, (b) Mascini et al[103] modified ZnO nanoparticles with peptides, (c) Tanaka et al[82] immobilized peptides specific to benzaldehyde on ZnO nanowires. (d) Jaffar-Bandjee et al[108] fabricated artificial "moth antennae" (e) Gray et al[109] proposed liposomes displaying tetrameric peptides to enable cooperative binding (f) Kotlowski et al[96] used a bio-functional linker to optimize the orientation of OBPs on a graphitic surface.…”

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confidence: 99%

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Bio-Inspired Strategies for Improving the Selectivity and Sensitivity of Artificial Noses: A Review

Hurot

Scaramozzino

Buhot

et al. 2020

Sensors

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Artificial noses are broad-spectrum multisensors dedicated to the detection of volatile organic compounds (VOCs). Despite great recent progress, they still suffer from a lack of sensitivity and selectivity. We will review, in a systemic way, the biomimetic strategies for improving these performance criteria, including the design of sensing materials, their immobilization on the sensing surface, the sampling of VOCs, the choice of a transduction method, and the data processing. This reflection could help address new applications in domains where high-performance artificial noses are required such as public security and safety, environment, industry, or healthcare.

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Section: Phage Displaymentioning

confidence: 99%

Section: Improvement Of the Selectivitymentioning

confidence: 99%

“…Zine et al [104] generated them directly in situ. Recently, Tanaka et al [82] immobilized selective peptides on ZnO nanowires, Figure 7b.…”

Section: Increase Of the Sensitivitymentioning

confidence: 99%

mentioning

confidence: 99%

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Bio-Inspired Strategies for Improving the Selectivity and Sensitivity of Artificial Noses: A Review

Hurot

Scaramozzino

Buhot

et al. 2020

Sensors

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“…16,17 Because peptides can be chemically synthesised in large batch scales, many functional peptides have been discovered from rational and systematic studies for a wide range of applications (e.g., targeting, sensing, imaging). [18][19][20] Importantly for the study of nanoparticle functionalisation, solid-binding peptides can bind or recognise material surfaces and offer simple and bio-friendly alternatives to conventional surface modication techniques. 21,22 So far, a few peptides have been reported to possess the capacity to bind to QDs based on histidine (His or H)-metal affinity.…”

Section: Introductionmentioning

confidence: 99%

Screening and characterisation of CdTe/CdS quantum dot-binding peptides for material surface functionalisation

et al. 2020

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Rational Design of Peptide Biorecognition Elements on Carbon Nanotubes for Sensing Volatile Organic Compounds

Sim

Kuang

Sant'Anna

et al. 2022

Adv Materials Inter

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compounds. Exhaled breath is one of the most accessible and zero-invasive samples to monitor human health and performance. For example, recent studies have demonstrated that analyzing the exhaled breath is practical for fast-diagnosing of COVID-19. [1,2] Volatile organic compounds (VOCs) [3][4][5][6] in the exhaled breath serve as performance-related biomarkers providing rich information on human physiological/physical statuses [7][8][9][10][11] such as psychological stress and fatigue level. A miniaturized sensor is key to building a wearable sensing suite with the capability to monitor human breath. Conventional VOC detection tools are either bulky or non-selective. For example, gas chromatography-mass spectrometry (GC-MS) is accepted as a gold standard for measuring breath VOCs. [12][13][14] However, GC-MS is bulky due to its heating and vacuum systems and requires a long operation time due to the VOC sampling and separation process. Photo-ionized detectors (PIDs) are another commercial off-the-shelf, portable VOC sensors commonly applied to gas sensing. [15,16] These sensors (VOC-TRAQ, MOCON, Inc., Minneapolis, MN, USA) range their dimensions Carbon nanotube (CNT) chemiresistors have emerged as miniaturized platforms for wearable volatile organic compound (VOC) sensors. As a promising biorecognition element (BRE), a short peptide can functionalize CNT to be sensitive and selective to target VOCs. However, unveiling the VOCoptimized peptide-CNT pair for gas-phase sensing remains unclear. Here, a novel multimodal molecular toolset for designing, building, and probing suitable BRE-CNT sensors using machine learning, molecular dynamics, and near-edge X-ray absorption fine structure spectroscopy is presented. This computational and experimental suite predicts the peptide conformation on the CNT surface and probes how the peptide-CNT interfaces affect the VOC sensing. Then, peptide-functionalized CNT chemiresistors are tested against various VOCs to confirm the efficacy of the toolkit. The results show that the vertically oriented peptide on the CNT surface hinders VOC access to the peptide-CNT interface, resulting in a significantly lower sensor signal than the CNT chemiresistor with the horizontally oriented peptide. The interactive computational and experimental results strongly indicate that a peptide conformation plays an important role in VOC sensing sensitivity.

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Peptide Screening from a Phage Display Library for Benzaldehyde Recognition

Cited by 14 publications

References 44 publications

Bio-Inspired Strategies for Improving the Selectivity and Sensitivity of Artificial Noses: A Review

Bio-Inspired Strategies for Improving the Selectivity and Sensitivity of Artificial Noses: A Review

Screening and characterisation of CdTe/CdS quantum dot-binding peptides for material surface functionalisation

Rational Design of Peptide Biorecognition Elements on Carbon Nanotubes for Sensing Volatile Organic Compounds

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