A CD9-binding peptide (RSHRLRLH), screened from EWI-2, was characterized, and its inhibition effect on cancer-cell migration and invasion was demonstrated.
Silver nanoparticles (AgNPs) were synthesized in skim natural rubber latex, the by-product from concentrated latex production. The role of ammonia was investigated by varying the concentration to be 0.217, 0.362, 0.377, 0.392, and 0.406 wt%. The emergence of AgNPs was detected by UV-visible spectrophotometer and electrical conductivity meter. Upon increasing ammonia concentration, the ABS peak increased to a maximum and slightly shifted to a higher wavelength and then it decreased afterward and slightly shifted to a lower wavelength. The shift of the ABS peak was consistent with the conductivity result. The kinetic model was proposed to explain the competition between the reducing effect and size-controlling effect of ammonia. The reducing effect seemed to dominate in the low range of concentration while the size-controlling effect via the formation of AgNH32+ complex ion was important in the higher range. The TEM figures evidently confirmed the effects.
Lipid tubules are of particular interest for many potential applications in nanotechnology. Among various lipid tubule fabrication techniques, the morphological regulation of membrane structure by proteins mimicking biological processes may provide the chances to form lipid tubes with highly tuned structures. Magnetotactic bacteria synthesize magnetosomes (a unique prokaryotic organelle comprising a magnetite crystal within a lipid envelope). MamY protein is previously identified as the magnetosome protein responsible for magnetosome vesicle formation and stabilization. Furthermore, MamY is shown in vitro liposome tubulation activity. In this study, the interaction of MamY and phospholipids is investigated by using a lipids-immobilized membrane strip and a peptide array. Here, the binding of MamY to the anionic phospholipid, cardiolipin, is found and enhanced liposome tubulation efficiency. The authors propose the interaction is responsible for recruiting and locating cardiolipin to elongate liposome in vitro. The authors also suggest a similar mechanism for the invagination site in magnetosomes vesicle formation, where the lipid itself contributes further to increasing the curvature. These findings are highly important to develop an effective biomimetic synthesis technique of lipid tubules and to elucidate the unique prokaryotic organelle formation in magnetotactic bacteria.
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