Peptide–Polymer Hybrid Nanotubes

Couet, Julien; Samuel, Jorice; Kopyshev, Alexey; Santer, Svetlana; Biesalski, Markus

doi:10.1002/anie.200462993

Cited by 206 publications

(188 citation statements)

References 25 publications

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“…The divergent route, whereby polymer chains are grown from the CP amino-acid side chains, can be achieved in a 'graft-from' procedure. For example, Couet et al 44,45 have employed this route to synthesize CP-polymer NTs from CPs bearing initiator side chains. Although the resulting CP-polymer NTs are uniform in length, it is difficult to assess the polymer molecular weight and uniformity as well as the overall polymergrafting density on the CP 45 , and this strategy does not allow for the conjugation of two different polymer chains to the CP core.…”

Section: Discussionmentioning

confidence: 99%

Janus cyclic peptide–polymer nanotubes

et al. 2013

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Self-assembled nanotubular structures have numerous potential applications but these are limited by a lack of control over size and functionality. Controlling these features at the molecular level may allow realization of the potential of such structures. Here we report a new generation of self-assembled cyclic peptide-polymer nanotubes with dual functionality in the form of either a Janus or mixed polymeric corona. A 'relay' synthetic strategy is used to prepare nanotubes with a demixing or mixing polymeric corona. Nanotube structure is assessed in solution using 1 H-1 H nuclear Overhauser effect spectroscopy NMR, and in bulk using differential scanning calorimetry. The Janus nanotubes form artificial pores in model phospholipid bilayers. These molecules provide a viable pathway for the development of intriguing nanotubular structures with dual functionality via a demixing or a mixing polymeric corona and may provide new avenues for the creation of synthetic transmembrane protein channel mimics.

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Section: Discussionmentioning

confidence: 99%

Janus cyclic peptide–polymer nanotubes

et al. 2013

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“…6,7 While the self-assembly of DNA, [8][9][10][11][12] peptides, 13,14 and other 15 types of filaments has been well-explored, relatively…”

mentioning

confidence: 99%

Self-assembly of precisely defined DNA nanotube superstructures using DNA origami seeds

et al. 2017

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“…Important principles of self-assembly are chemical complementarity and structural compatibility through weak and noncovalent interactions. Different construction units, such as well ordered nanofiber scaffolds [233,234], peptide nanotubes [235][236][237], segmented surface assembling peptides as a 'molecular carpet' [238][239][240] and dipolar molecules with changeable conformation as a 'molecular switch' [241][242][243], can be realized by specially designed peptide units and sequences. However, the realization of peptide scaffolds by molecular self-assembly is extremely extensive and it depends on elaborate techniques.…”

Section: Self-assembly Systemsmentioning

confidence: 99%

Design and preparation of polymeric scaffolds for tissue engineering

Weigel

Schinkel

Lendlein

2006

Expert Review of Medical Devices

207

154

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Polymeric scaffolds for tissue engineering can be prepared with a multitude of different techniques. Many diverse approaches have recently been under development. The adaptation of conventional preparation methods, such as electrospinning, induced phase separation of polymer solutions or porogen leaching, which were developed originally for other research areas, are described. In addition, the utilization of novel fabrication techniques, such as rapid prototyping or solid free-form procedures, with their many different methods to generate or to embody scaffold structures or the usage of selfassembly systems that mimic the properties of the extracellular matrix are also described. These methods are reviewed and evaluated with specific regard to their utility in the area of tissue engineering.Expert Rev. Med. Devices 3(6), 835-851 (2006) The technology of tissue engineering aims to generate new or substitute damaged or malfunctioning tissue or organs and could well become an alternative method to whole organ transplantation [1][2][3][4][5][6]. In the last decade particularly, enormous advances have been made in the area of tissue regeneration for therapeutical purposes. Tissue engineering is an interdisciplinary research area in which principles of material science/engineering and cell biology/life science are combined. The methods of tissue engineering have been applied to different types of tissue, including skin [7][8][9][10][11], bone [12][13][14][15][16], liver [17][18][19][20][21], intestine [22][23][24][25][26][27], esophagus [28][29][30][31][32], valve leaflets [33][34][35][36], muscle [37][38][39] and tongue [40][41][42], the vascular system [43][44][45][46][47], for craniofacial defects [48][49][50], tendons and ligaments [51][52][53][54][55], cartilage [56][57][58][59][60] and nerve tissue [61][62][63][64][65]. Since the early commercialization of tissue-engineered applications, for example, the work of Bell and colleagues [66], research with stem cells [3,[67][68][69] and the use of growth factors [70][71][72][73] that support cell differentiation and proliferation, have provided new opportunities in the field of tissue engineering. At present, tissue engineering methods generally require the use of a porous scaffold that serves as a matrix for initial cell attachment and subsequently for tissue formation in vitro and in vivo. Up to now scaffolds made from biomaterials have temporarily substituted the extracellular matrix (ECM). Such biomaterials can be of natural origin, such as organic collagen [74][75][76], fibrin glue [77][78][79], hyaluronic acid [80][81][82] or the inorganic-like coralline [83,84]. Synthetic polymeric materials have also been investigated, including, for example, aliphatic, copolyesters [85][86][87], polyhydroxyalkanoates [88][89][90] and polyethylene glycol [91,92], or inorganic materials, such as hydroxyapatite [48,93,94], tricalciumphosphate [95,96], glass ceramics and glass [97][98][99].The intrinsic material properties, such as the mechanical [100] or thermal [101,102] be...

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Peptide–Polymer Hybrid Nanotubes

Cited by 206 publications

References 25 publications

Janus cyclic peptide–polymer nanotubes

Janus cyclic peptide–polymer nanotubes

Self-assembly of precisely defined DNA nanotube superstructures using DNA origami seeds

Design and preparation of polymeric scaffolds for tissue engineering

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