Self-assembly of precisely defined DNA nanotube superstructures using DNA origami seeds

Mohammed, Abdul M.; Velazquez, Lourdes; Chisenhall, A.; Schiffels, Daniel; Fygenson, Deborah Kuchnir; Schulman, Rebecca

doi:10.1039/c6nr06983e

Cited by 37 publications

(46 citation statements)

References 24 publications

(29 reference statements)

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“…DNA cages refer to wireframe architectures assembly from DNA strands (Chen and Seeman, 1991;Wang et al, 2019). Various DNA cages include DNA polyhedrons (Wang et al, 2019) and DNA nanotube (Jorgenson et al, 2017;Mohammed et al, 2017) were reported. DNA polyhedrons represent a 3D cage-like compact structure which is stable and easily absorbed by cells.…”

Section: Wireframe Dna Cagesmentioning

confidence: 99%

DNA Nanostructure as an Efficient Drug Delivery Platform for Immunotherapy

Chi

Yang

et al. 2020

Front. Pharmacol.

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Immunotherapy has received increasing attention due to its low potential side effects and high specificity. For instance, cancer immunotherapy has achieved great success. CpG is a well-known and commonly used immunotherapeutic and vaccine adjuvant, but it has the disadvantage of being unstable and low in efficacy and needs to be transported through an effective nanocarrier. With perfect structural programmability, permeability, and biocompatibility, DNA nanostructures are one of the most promising candidates to deliver immune components to realize immunotherapy. However, the instability and low capability of the payload of ordinary DNA assemblies limit the relevant applications. Consequently, DNA nanostructure with a firm structure, high drug payloads is highly desirable. In the paper, the latest progress of biostable, high-payload DNA nanoassemblies of various structures, including cage-like DNA nanostructure, DNA particles, DNA polypods, and DNA hydrogel, are reviewed. Cage-like DNA structures hold drug molecules firmly inside the structure and leave a large space within the cavity. These DNA nanostructures use their unique structure to carry abundant CpG, and their biocompatibility and size advantages to enter immune cells to achieve immunotherapy for various diseases. Part of the DNA nanostructures can also achieve more effective treatment in conjunction with other functional components such as aPD1, RNA, TLR ligands.

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Section: Wireframe Dna Cagesmentioning

confidence: 99%

DNA Nanostructure as an Efficient Drug Delivery Platform for Immunotherapy

Chi

Yang

et al. 2020

Front. Pharmacol.

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“…Hierbei zeigten Röhren mit Origami‐Keimen eine wesentlich höhere Wachstumsrate als in unbehandelten Ansätzen . Die Hybridisierung zweier Keime mittels dsDNA‐Verbindungsstück führt zur Bildung von Nanoröhren in Form von “Nunchakus” . Keimbildner mit L‐, T‐ oder Y‐Form erzeugen entsprechende DNA‐Nanoröhren mit einer Länge von 2 oder 3 μm .…”

Section: Design‐strategienunclassified

Biomimetische DNA‐Nanoröhren: Gezielte Synthese und Anwendung nanoskopischer Kanäle

Liu

Zhao

et al. 2019

Angewandte Chemie

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Biomakromolekulare Nanoröhren spielen eine wichtige physiologische Rolle für transmembranäre Transportvorgänge von Ionen/Molekülen im intrazellulären Transport und in der interzellulären Kommunikation. Während genetisch kodierte Protein‐Nanoröhren das In‐vivo‐Geschehen dominieren, findet seit Anbruch der strukturellen DNA‐Nanotechnologie die In‐vitro‐Konstruktion biomimetischer DNA‐Nanoröhren zunehmende Beachtung. Der abiotische Gebrauch der DNA‐Assemblierung stellt einen potenten Bottom‐up‐Ansatz zur rationalen Erstellung komplexer Materialien in beliebiger Größe und Form im Nanomaßstab zur Verfügung. So kann eine typische DNA‐Nanoröhre entweder mittels parallel ausgerichteter DNA‐Doppelstrukturen oder über ein geschlossenes DNA‐Kachelgitter assembliert werden. Diese künstlichen DNA‐Nanoröhren können maßgeschneidert und targetspezifisch modifiziert werden, um ihre biomimetischen Funktionen zu erfüllen, wie z. B. für den Transport von Ionen/Molekülen, für Bioreaktoren, Wirkstofftransport und Biomolekularsensorik. Dieser Aufsatz zielt darauf ab, die jüngsten Fortschritte der Entwicklungsstrategien zusammenzufassen, einschließlich der Beschreibung und Anwendung biomimetischer DNA‐Nanoröhren.

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“…As we all know, Self-Assembly is commonly regarded as an emerging technology which could be used in nano-fabrication or computation because of its nanoscale feature size [1,[7][8][9][10][11]. In nano-manufacture system and algorithmic system, DNA is applied in Self-Assembly as a main technology because of its wonderful versatility.…”

Section: Introductionmentioning

confidence: 99%

Analysis of Effect of Symmetric Tiles on Binary Counter in DNA Self-Assembly

Zhu¹,

Chen²,

Hu³

et al. 2018

Proceedings of the 2018 Joint International Advanced Engineering and Technology Research Conference (JIAET 2018)

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With the growth of complicate system or crystals, whereas, a few phenomena have occurred and been found, which could result in final crystals or patterns with errors. Among those phenomena, one has still not been processed in current published literatures, which is named symmetry tile may appear. This paper analyses the effect of symmetry tile on binary counter in DNA Self-Assembly. The exact relationship between symmetry tile and counting is set up considering the type of symmetry and the position of the symmetry tile. The analysis shows that the final patterns are partly or completely different from the originally desired patterns in the case of symmetry tile due to the changed counting behavior. Simulation results which are obtained by Xgrow demonstrate that the analysis is valid and correct.

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Self-assembly of precisely defined DNA nanotube superstructures using DNA origami seeds

Cited by 37 publications

References 24 publications

DNA Nanostructure as an Efficient Drug Delivery Platform for Immunotherapy

DNA Nanostructure as an Efficient Drug Delivery Platform for Immunotherapy

Biomimetische DNA‐Nanoröhren: Gezielte Synthese und Anwendung nanoskopischer Kanäle

Analysis of Effect of Symmetric Tiles on Binary Counter in DNA Self-Assembly

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