Peptide functionalized targeting liposomes: for nanoscale drug delivery towards angiogenesis

Abstract

VEGFR2-targeted peptide S1 functionalized liposomes show high drug delivery towards targeted tumors.

Paclitaxel prodrug based mixed micelles for tumor-targeted chemotherapy

“…Herein, the uorescence intensity of the DiR loaded MMs was monitored in comparison with the unmodied DiR-loaded SMs using a NIR uorescence imaging system for 12 h to evaluate the targeting ability of different nanoparticles in the H22 tumorbearing mice. 34 Fig. 5A shows the in vivo images at the tumor site aer the intravenous injection of the DiR loaded SMs and MMs at different time points.…”

Immunomodulatory Lipocomplex Functionalized with Photosensitizer-Embedded Cancer Cell Membrane Inhibits Tumor Growth and Metastasis

“…Several liposome-encapsulated anticancer drugs (e.g., Doxil and Myocet) are in clinical use for the treatment of several types of cancer . However, the anticancer drugs insufficiently accumulate (<1%) in the tumor site because the drug-loaded liposomes are targeted to tumors passively via the enhanced permeability and retention (EPR) effect of leaky blood vessels in tumors. − Moreover, unexpected drug leakage from the liposomal carriers before they reach the tumor site exerts cytotoxic side effects on healthy cells and can lead to failure of tumor eradication. − To enhance the cancer-targeting efficiency of liposomal carriers, they have been decorated with various targeting moieties, such as peptides, aptamers, and antibodies. − However, integration of the targeting moieties requires multiple chemical reactions and formulation processes that inevitably pose problems of low stability, poor reproducibility, and complicated assessments. , Hence, a facile and efficient method for liposome modification is required to improve liposomal carrier-based chemotherapy.…”