Immunomodulatory Lipocomplex Functionalized with Photosensitizer-Embedded Cancer Cell Membrane Inhibits Tumor Growth and Metastasis

Kim, Han Young; Kang, Mikyung; Choo, Yeon Woong; Go, Seokhyeong; Kwon, Sung Pil; Song, Seuk Young; Sohn, Hee Su; Hong, Jihye; Kim, Byung Soo

doi:10.1021/acs.nanolett.9b01571

Cited by 76 publications

(45 citation statements)

References 42 publications

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“…Cell‐membrane‐derived biomimetic nanoplatforms have revolutionized the design of cancer vaccine by providing targeted delivery, specific recognition, antigen presentation, and immune stimulation [ 1 ] and diverse eukaryotic membrane vesicles have been developed for vaccine design, including blood cells, [ 2 ] immune cells, [ 3 ] and especially cancer cells. [ 4 ] The specific antigens expressed on cancer cell membrane vesicles (CMVs) can be processed by mature antigen presenting cells (APCs) to trigger the anticancer immunity based on the cytotoxic T lymphocytes (CTLs). Despite this fundamental role in vaccine design, the mono‐CMVs suffer from the lack of efficient immunostimulation to APCs, which necessitates more comprehensive CMV‐based strategies.…”

Section: Figurementioning

confidence: 99%

A Hybrid Eukaryotic–Prokaryotic Nanoplatform with Photothermal Modality for Enhanced Antitumor Vaccination

et al. 2020

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The ORCID identification number(s) for the author(s) of this article can be found under https://doi.org/10.1002/adma.201908185.Cell-membrane-derived biomimetic nanoplatforms have revolutionized the design of cancer vaccine by providing targeted delivery, specific recognition, antigen presentation, and immune stimulation [1] and diverse eukaryotic membrane vesicles have been developed for vaccine design, including blood cells, [2] Adv.

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Section: Figurementioning

confidence: 99%

A Hybrid Eukaryotic–Prokaryotic Nanoplatform with Photothermal Modality for Enhanced Antitumor Vaccination

et al. 2020

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“…because of the relatively low molecular weight of the lipids involved in liposomes (1,200-1,800 g/mol) compared with the surfactants used in micelles (>8,000 g/mol). Inadvertent leakage remains a concern in antimicrobial-loaded systems (Kim et al, 2019).…”

Section: Introductionmentioning

confidence: 99%

Lipid-Based Antimicrobial Delivery-Systems for the Treatment of Bacterial Infections

et al. 2020

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Many nanotechnology-based antimicrobials and antimicrobial-delivery-systems have been developed over the past decades with the aim to provide alternatives to antibiotic treatment of infectious-biofilms across the human body. Antimicrobials can be loaded into nanocarriers to protect them against de-activation, and to reduce their toxicity and potential, harmful side-effects. Moreover, antimicrobial nanocarriers such as micelles, can be equipped with stealth and pH-responsive features that allow self-targeting and accumulation in infectious-biofilms at high concentrations. Micellar and liposomal nanocarriers differ in hydrophilicity of their outer-surface and inner-core. Micelles are self-assembled, spherical core-shell structures composed of single layers of surfactants, with hydrophilic head-groups and hydrophobic tail-groups pointing to the micellar core. Liposomes are composed of lipids, self-assembled into bilayers. The hydrophilic head of the lipids determines the surface properties of liposomes, while the hydrophobic tail, internal to the bilayer, determines the fluidity of liposomal-membranes. Therefore, whereas micelles can only be loaded with hydrophobic antimicrobials, hydrophilic antimicrobials can be encapsulated in the hydrophilic, aqueous core of liposomes and hydrophobic or amphiphilic antimicrobials can be inserted in the phospholipid bilayer. Nanotechnology-derived liposomes can be prepared with diameters <100-200 nm, required to prevent reticulo-endothelial rejection and allow penetration into infectious-biofilms. However, surface-functionalization of liposomes is considerably more difficult than of micelles, which explains while self-targeting, pH-responsive liposomes that find their way through the blood circulation toward infectious-biofilms are still challenging to prepare. Equally, development of liposomes that penetrate over the entire thickness of biofilms to provide deep killing of biofilm inhabitants still provides a challenge. The liposomal phospholipid bilayer easily fuses with bacterial cell membranes to release high antimicrobial-doses directly inside bacteria. Arguably, protection against de-activation of antibiotics in liposomal nanocarriers and their fusogenicity constitute the biggest advantage of liposomal antimicrobial carriers over antimicrobials free in solution. Many Gram-negative and Gram-positive bacterial strains, resistant to specific antibiotics, Wang et al. Lipid-Based Antimicrobial Delivery-Systems have been demonstrated to be susceptible to these antibiotics when encapsulated in liposomal nanocarriers. Recently, also progress has been made concerning large-scale production and long-term storage of liposomes. Therewith, the remaining challenges to develop self-targeting liposomes that penetrate, accumulate and kill deeply in infectious-biofilms remain worthwhile to pursue.

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“…Reproduced with permission. [ 141 ] Copyright 2019, American Chemical Society. C) Schematic illustration of the preparation and mechanism of fused cell membrane‐coated nanoparticles as cell membrane vaccines for tumor prevention.…”

Section: Cellular Communicationmentioning

confidence: 99%

Recent Advances of Cell Membrane‐Coated Nanomaterials for Biomedical Applications

Liu

Zou

Qin

et al. 2020

Adv Funct Materials

135

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Surface modification of nanomaterials is essential for their biomedical applications owing to their passive immune clearance and damage to reticuloendothelial systems. Recently, a cell membrane-coating technology has been proposed as an ideal approach to modify nanomaterials owing to its facile functionalized process and good biocompatibility for improving performances of synthetic nanomaterials. Here, recent advances of cell membrane-coated nanomaterials are reviewed based on the main biological functions of the cell membrane in living cells. An overview of the cell membrane is introduced to understand its functions and potential applications. Then, the applications of cell membrane-coated nanomaterials based on the functions of the cell membrane are summarized, including physical barrier with selective permeability and cellular communication via information transmission and reception processes. Finally, perspectives of biomedical applications and challenges about cell membrane-coated nanomaterials are discussed.

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Immunomodulatory Lipocomplex Functionalized with Photosensitizer-Embedded Cancer Cell Membrane Inhibits Tumor Growth and Metastasis

Cited by 76 publications

References 42 publications

A Hybrid Eukaryotic–Prokaryotic Nanoplatform with Photothermal Modality for Enhanced Antitumor Vaccination

A Hybrid Eukaryotic–Prokaryotic Nanoplatform with Photothermal Modality for Enhanced Antitumor Vaccination

Lipid-Based Antimicrobial Delivery-Systems for the Treatment of Bacterial Infections

Recent Advances of Cell Membrane‐Coated Nanomaterials for Biomedical Applications

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