Peptide-functionalized semiconductor surfaces: strong surface electronic effects from minor alterations to backbone composition

Matmor, Maayan; Lengyel, George A.; Horne, W. Seth; Ashkenasy, Nurit

doi:10.1039/c6cp07198h

Cited by 9 publications

(5 citation statements)

References 36 publications

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“…For example, X-ray photoelectron spectroscopy data for GaAs with water reveals shift in the As 2p due to the formation of As-H 36 . In a separate study, the FTIR peak assigned to the amino group is found shifted due to its adsorption at the GaAs surface 37 . Therefore, cross-correlation between the differential conduction of the bare Schottky GaAs and those of the diode in contact with the amino acids can quantify the modification to the GaAs chemisorption.…”

Section: Ongoing and Future Workmentioning

confidence: 86%

Detection of some amino acids with modulation-doped and surface-nanoengineered GaAs Schottky P-I-N diodes

Alkhidir

Jaoudé

Gater

et al. 2020

Journal of Vacuum Science &Amp; Technology B, Nanotechnology and Microelectronics: Materials, Processing, Measurement, and Phen

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Most current techniques for analyzing amino acids require substantial instrumentation and significant sample preprocessing. In this study, we designed, fabricated and tested a scalable diode-based microdevice that allows for direct sensing of amino acids. The device is based on modulation-doped GaAs heterostructure with a Schottky contact on one side. The relatively high mobility and relatively small dielectric constant of GaAs are naturally helpful in this problem. We also paid attention to a proper etching procedure allowing for substantial modification of the surface properties, thereby further boosting the sensing performance. Transport data (I-V, differential conductance) are presented for three qualitatively different classes of amino acids (i.e. non-polar with aliphatic R-group, polar uncharged R-group and charged R-group) with glycine, cysteine and histidine as specific examples, respectively. The conductance for the GaAsamino acid interface measured using scanning tunneling microscope (STM) was previously reported to have distinct spectral features. In this paper, we show that measuring the differential conductance of GaAs diode whose surface is in direct contact with an aqueous solution of amino acid, is a simple methodology to access useful information, previously available only through sophisticated and equipment-demanding STM and molecular electronics approaches. Density functional theory (DFT) calculations were used to examine which adsorption processes were likely responsible for the observed surface conductance modification. Lastly, in future and ongoing work, we illustrate how it might be possible to employ standard multivariate data analysis techniques to reliably identify distinct (95%) single amino acid specific features in near-ambient differential conductance data. Research questions we address here are: (1) is it possible to distinguish between different amino acids in contact with the same GaAs interface, based on I-V curves?; (2) how are partial charges specific to individual amino acids?; (3) what are the likely binding mechanisms (individual amino acid to GaAs)?; and (4) to what extent one can use differential conductance data? We show how it is possible to distinguish between separate aqueous solutions of the amino acids in in-This is the author's peer reviewed, accepted manuscript. However, the online version of record will be different from this version once it has been copyedited and typeset.

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Section: Ongoing and Future Workmentioning

confidence: 86%

Detection of some amino acids with modulation-doped and surface-nanoengineered GaAs Schottky P-I-N diodes

Alkhidir

Jaoudé

Gater

et al. 2020

Journal of Vacuum Science &Amp; Technology B, Nanotechnology and Microelectronics: Materials, Processing, Measurement, and Phen

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“…This study emphasized the important role of peptides as tools for improving the electronic properties of FET. [ 318 ] Mehlhose et al synthesized novel helical peptides based on (Leu‐Aib)n sequences that were chemically coupled to gallium nitride (GaN) surfaces. GaN exhibited good electrochemical stability over a wide frequency window, and the controllable electronic properties made it possible to fabricate various heterostructures.…”

Section: Applications Of Peptide‐based Bioelectronic Materials and De...mentioning

confidence: 99%

Rational Design of Bio‐Inspired Peptide Electronic Materials toward Bionanotechnology: Strategies and Applications

Zhao,

Liu,

Tong

et al. 2024

Adv Funct Materials

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Biologically inspired peptide‐based materials, as novel charge transport materials, have gained increasing interest in bioelectronics due to their remarkable electrical properties and inherent biocompatibility. Extensive studies have shown that peptides can self‐assemble into a variety of hierarchical nanostructures with unique physical properties through supramolecular interactions. Therefore, peptide‐based materials hold great promise for applications in emerging electronic fields such as sensing, energy harvesting, energy storage, and electronic transmission. Herein, this work proposes a review article to summarize the rational design and research progress of peptide‐based materials and devices in bioelectronics. This work first introduces the design strategies and assembly mechanism for constructing high‐performance peptide‐based electronic materials and devices. In the following part, the applications of peptide‐based electronic materials and devices are systematically classified and discussed, including sensors, piezoelectric nanogenerators, electrodes, and semiconductors. Finally, the remaining challenges and future perspectives of peptide‐based bioelectronic materials and devices are presented. This work believes that this review will provide inspiration and guidance for the design and development of innovative peptide‐based smart materials in the field of bioelectronics.

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“…[8][9][10][11][12] Accordingly, significant efforts were devoted to reveal the effects of peptide adlayers on the surface work function of metals and semiconductors. [13][14][15][16][17][18] The surface work function was found to be affected by the nature of the amino acids 13 and by their position in the peptide sequence, 14 as well as the structure of the peptide backbone. 15 The applicability of this approach was demonstrated through the incorporation of basic amino acids in the sequence of short peptide functionalization layers to reduce the work function of transparent conductive oxides and graphene in order to improve their performance as a cathode for a device.…”

Section: Introductionmentioning

confidence: 99%

“…[13][14][15][16][17][18] The surface work function was found to be affected by the nature of the amino acids 13 and by their position in the peptide sequence, 14 as well as the structure of the peptide backbone. 15 The applicability of this approach was demonstrated through the incorporation of basic amino acids in the sequence of short peptide functionalization layers to reduce the work function of transparent conductive oxides and graphene in order to improve their performance as a cathode for a device. 8,[16][17][18][19][20] However, to the best of our knowledge, the influence of multivalent interactions on the surface electronic properties, and the work function in particular, has not yet been explored.…”

Section: Introductionmentioning

confidence: 99%

Enhancement of electronic effects at a biomolecule–inorganic interface by multivalent interactions

Kramer

Sivron

Saux

et al. 2023

Phys. Chem. Chem. Phys.

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Peptide-functionalized semiconductor surfaces: strong surface electronic effects from minor alterations to backbone composition

Cited by 9 publications

References 36 publications

Detection of some amino acids with modulation-doped and surface-nanoengineered GaAs Schottky P-I-N diodes

Detection of some amino acids with modulation-doped and surface-nanoengineered GaAs Schottky P-I-N diodes

Rational Design of Bio‐Inspired Peptide Electronic Materials toward Bionanotechnology: Strategies and Applications

Enhancement of electronic effects at a biomolecule–inorganic interface by multivalent interactions

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