Peptide-directed crystal growth modification in the formation of ZnO

Sola-Rabada, Anna; Liang, Mei-Keat; Roe, Martin; Perry, Carole C.

doi:10.1039/c5tb00253b

Cited by 18 publications

(41 citation statements)

References 52 publications

(115 reference statements)

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“…First, by having dodecamer peptides with 12 residues varied over the 20 canonical amino acids, the diversity of functional group compositions (hydrophobic, hydrophilic, aromatic, and positively and negatively charged) and arrangement within the sequence is enormous, allowing for rapid fine-tuning of the interactions of the peptides with the inorganic surface. This is important as recent studies have demonstrated that localized changes in these bioorganic structures can have dramatic implications over both the peptide affinity and the nanoparticle surface structure, − which can be very difficult to achieve using traditional organic ligands. Second, the phage-display process is inherently biased against the incorporation of cysteine residues into the variable peptide domains.…”

Section: Bioinspired Nanotechnologymentioning

confidence: 99%

Biointerface Structural Effects on the Properties and Applications of Bioinspired Peptide-Based Nanomaterials

2017

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Peptide sequences are known to recognize and bind different nanomaterial surfaces, which has resulted in the screening and identification of hundreds of peptides with the ability to bind to a wide range of metallic, metal oxide, mineral, and polymer substrates. These biomolecules are able to bind to materials with relatively high affinity, resulting in the generation of a complex biointerface between the biotic and abiotic components. While the number of material-binding sequences is large, at present, quantitative materials-binding characterization of these peptides has been accomplished only for a relatively small number of sequences. Moreover, it is currently very challenging to determine the molecular-level structure(s) of these peptides in the materials adsorbed state. Despite this lack of data related to the structure and function of this remarkable biointerface, several of these peptide sequences have found extensive use in creating functional nanostructured materials for assembly, catalysis, energy, and medicine, all of which are dependent on the structure of the individual peptides and collective biointerface at the material surface. In this Review, we provide a comprehensive overview of these applications and illustrate how the versatility of this peptide-mediated approach for the growth, organization, and activation of nanomaterials could be more widely expanded via the elucidation of biointerfacial structure/property relationships. Future directions and grand challenges to realize these goals are highlighted for both experimental characterization and molecular-simulation strategies.

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Section: Bioinspired Nanotechnologymentioning

confidence: 99%

Biointerface Structural Effects on the Properties and Applications of Bioinspired Peptide-Based Nanomaterials

2017

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“…[15][16][17] Of specific interest, in-house studies have been carried out to understand the fundamental principles through which ZnO binding peptides (ZnO-BPs) interact with and modify ZnO growth process and morphology. 6,8,18 In a recent contribution, the mechanisms through which specific ZnO binding peptides (ZnO-BPs) interact with and modify the growth process and morphology of ZnO during solution synthesis was described. 8 The peptides used in the study were PD identified G-12 (GLHVMHKVAPPR) peptide, its derivative GT-16 (GLHVMHKVAPPR-GGGC) and alanine mutants of the G-12 peptide.…”

Section: Introductionmentioning

confidence: 99%

Thermodynamic Study of Interactions Between ZnO and ZnO Binding Peptides Using Isothermal Titration Calorimetry

Limo

Perry

2015

Langmuir

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Whilst material specific peptide binding sequences have been identified using a combination of combinatorial methods and computational modelling tools, a deep molecular level understanding of the fundamental principles through which these interactions occur and in some instances modify the morphology of inorganic materials is far from being fully realized. Understanding the thermodynamic changes that occur during peptide-inorganic interactions and correlating these to structural modifications of the inorganic materials could be the key to achieving and mastering control over material formation processes. This study is a detailed investigation applying isothermal titration calorimetry (ITC) to directly probe thermodynamic changes that occur during interaction of ZnO binding peptides (ZnO-BPs) and ZnO. The ZnO-BPs used are reported sequences G-12 (GLHVMHKVAPPR), GT-16 (GLHVMHKVAPPR-GGGC) and alanine mutants of G-12 (G-12A6, G-12A11 and G-12A12) whose interaction with ZnO during solution synthesis studies have been extensively investigated. The interactions of the ZnO-BPs with ZnO yielded biphasic isotherms comprising both an endothermic and an exothermic event. Qualitative differences were observed in the isothermal profiles of the different peptides and ZnO particles studied. Measured ∆G values were between -6 and -8.5 kcal/mol and high adsorption affinity values indicated the occurrence of favourable ZnO-BP-ZnO interactions. ITC has great potential in its use to understand peptide-inorganic interactions and with continued development, the knowledge gained may be instrumental for simplification of selection processes of organic molecules for the advancement of material synthesis and design.

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“…In advancing our understanding of peptide mineral interactions a clear understanding of the solution behavior of both the peptide and the mineral is needed before the interaction of the two can be understood. As examples, in our research we have shown that by careful study of the particular properties of the material itself, for example silica [29,30,134] and ZnO [57,135,136] we can show that the size of particles [29,30,134] and charge/ functionality on particles [30,137] have clear effects on the binding of small peptides to minerals as well as the route by which a material is formed [57,135,136] by moderating peptide mineral interaction.…”

Section: Current and Future Directionsmentioning

confidence: 72%

A Review on Recent Patents and Applications of Inorganic Material Binding Peptides

Thota

Perry

2017

NANOTEC

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Over the past decade, significant progress has been made in the identification of novel material binding peptides having affinity to a wide range of target materials and their use in nanobiotechnological innovations. These material binding peptides (MBPs), also known as solid/ substance binding peptides (SBPs) can be isolated using combinatorial display technologies such as phage display (PD), surface display (cell, bacterial, yeast, mRNA) exhibit material specific selectivity and affinity towards a range of inorganic and organic nanomaterial surfaces including metals, metal oxides, minerals, semiconductors and biomolecules. MBPs serve as mediators in bringing nanotechnology and biotechnology under one umbrella by linking solid nanoparticles with biomolecules including proteins, bioactive peptide motifs, bifunctional binding peptides, enzymes, antigens and antibody fragments. As the utilization and application of these inorganic binding peptides as molecular connectors, molecular assemblers and material specific synthesizers in nanotechnology has been expanding rapidly, so too has growing commercial interest in patenting such innovations. In this review, we present the past, current and future developments and applications of inorganic MBPs specific to nanomaterials and their applications.

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Peptide-directed crystal growth modification in the formation of ZnO

Abstract: ZnO-binding peptides, differing only by Met or Cys at position 5 modify the mechanism of ZnO crystal growth.

Cited by 18 publications

References 52 publications

Biointerface Structural Effects on the Properties and Applications of Bioinspired Peptide-Based Nanomaterials

Biointerface Structural Effects on the Properties and Applications of Bioinspired Peptide-Based Nanomaterials

Thermodynamic Study of Interactions Between ZnO and ZnO Binding Peptides Using Isothermal Titration Calorimetry

A Review on Recent Patents and Applications of Inorganic Material Binding Peptides

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