Peptide‐Conjugated Nano‐Drug Delivery System to Improve Synergistic Molecular Chemotherapy for Colon Carcinoma

Rayappan, Kathirvel; Murugan, Chandran; Kannan, R.; Portillo-Lara, Roberto; Kannan, Soundarapandian

doi:10.1002/slct.201701153

Cited by 8 publications

(4 citation statements)

References 49 publications

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“…This could elucidate the possible interaction of the nanomaterial with endolysosome membranes because of transitory undermining of the cell membranes, resulting in the easy entry of the nanomaterial into the cytosol. 40 , 41 At this stage, the BBR is released from FA-PEG@BBR-AgNPs, after the accretion of the nanomaterial in MDA-MB-231 cells. The aim of the study is to assess the MDA-MB-231 cell-targeting capability of the nanocarrier such as BBR-AgNPs and FA-PEG@BBR-AgNPs through FA receptor-binding efficacy (over-expressed in many types of cancer).…”

Section: Resultsmentioning

confidence: 99%

Drug-Carrying Capacity and Anticancer Effect of the Folic Acid- and Berberine-Loaded Silver Nanomaterial To Regulate the AKT-ERK Pathway in Breast Cancer

2018

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Currently, in clinics, breast cancer is treated with free chemotherapeutic drugs, as a result there is not much therapeutic effect in treated models, leading to substantial systemic toxicity. To overcome these critical problems for the primary outcome, we developed the formulated nanomaterial (FA-PEG@BBR-AgNPs) aimed to specifically target cancer cells via nanoscopic-based drug delivery for getting better therapeutic effectiveness. In the present study, an isoquinoline alkaloid, berberine (BBR), was chosen as a cancer therapeutic agent, encapsulated on citrate-capped silver nanoparticles (AgNPs) through electrostatic interactions (BBR-AgNPs). Then, BBR-AgNPs were conjugated with polyethylene glycol-functionalized folic acid (FA-PEG) via hydrogen bonding interactions (FA-PEG@BBR-AgNPs). The transmission electron microscopy study shows the cellular invasion of the formulated FA-PEG@BBR-AgNPs, indicating the accretion of the nanomaterial at the tumor-specific site. Hence, FA conjugated with the nanomaterial suggests an efficient release of BBR molecules into the specific cancer site. Consequently, the results showed an increase in apoptotic induction via reactive oxygen species and condensed nuclei in cancer cells. Moreover, the western blotting analysis shows reduced/increased expression of PI3K, AKT, Ras, Raf, ERK, VEGF, HIF1α, Bcl-2, Bax, cytochrome c, caspase-9, and caspase-3, thereby enhancing apoptosis. Likewise, the in vivo antitumor efficiency of FA-PEG@BBR-AgNPs showed a significant restraint of tumor progression, and histopathological observations of lung, liver, kidney, heart, and brain tissues proved lesser toxicity of FA-PEG@BBR-AgNPs. Thus, the successfully formulated nanomaterial can serve as a potential drug-discharging vehicle to combat cancer cells by a molecular-based targeting approach.

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Section: Resultsmentioning

confidence: 99%

Drug-Carrying Capacity and Anticancer Effect of the Folic Acid- and Berberine-Loaded Silver Nanomaterial To Regulate the AKT-ERK Pathway in Breast Cancer

2018

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“…Human MDA-MB-231 breast cancer cells were collected from the National Center for Cell Science, Pune, India and stored in DMEM media enriched with 10% FBS, 1% Lglutamine, 1% penicillin, and 1% streptomycin stock solution, at 37°C and 5% CO 2 . The medium was modified every two days and the cells were transferred by trypsinization prior to confluence [30][31][32].…”

Section: Cell Lines and Cell Culturementioning

confidence: 99%

Eco-Friendly Formulation of Selenium Nanoparticles and Its Functional Characterization against Breast Cancer and Normal Cells

Rajasekar¹,

Kuppusamy²

2020

J Clust Sci

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In the recent years, targeted cancer therapy induced by nanoparticles has been more effective than other treatment options; in addition, the green formulation of metal or non-metallic nanoparticles are of tremendous concern due to appreciation therapeutic performance with low toxicity to mammalian cells. Here, we reported eco-friendly formulation of selenium nanoparticles (SeNPs) achieved by biological route utilizing the Carica papaya latex. The UV-Visible Spectrophotometer (UV-Vis) analysis, Fourier-transform infrared spectroscopy (FT-IR), X-ray powder diffraction (XRD), dynamic light scattering (DLS), and Transmission electron microscopy (TEM) analysis were used to confirm the SeNPs formation. MTT assay proved its biological properties such as anti-cancer efficacy against the cultured MDA-MB-231 cells. The findings showed that MDA-MB-231 cells were severely impacted by the green synthesized SeNPs as compared with the normal HBL100 cell line. The IC 50 value of green synthesized SeNPs toward MDA-MB-231 cells was noted to be 34 lg/mL for 48 h, while HBL-100 cells showed no cytotoxic effects at concentrations as high above 50 lg/mL for 48 h over SeNPs. Our finding indicates that the delivery of biosynthesized SeNPs has a greater clinical efficiency for MDA-MB-231 breast cancer cells.

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“…As a result, nanomedicine has garnered considerable interest in the scientific community as a promising avenue for diagnosing, treating, and preventing immune and tumor diseases. [ 2,3 ]…”

Section: Introductionmentioning

confidence: 99%

Composite Nanoplatforms Based on Nanocalcium Peroxide for Cancer Treatment: From Monotherapy to Combination Therapy

Liu

Wang

et al. 2023

Advanced Therapeutics

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Nano‐CaO2, with its multifunctional properties, has emerged as a promising candidate for tumor therapy. Its ability to release Ca2+ and H2O2 into the tumor microenvironment has positively modulated abnormal calcium signaling and kinetic therapy. Moreover, the indirectly produced O22− by CaO2 can alleviate hypoxic conditions. On the one hand, the accumulation of Ca2+ can lead to various tumor cell apoptosis events, such as calcium overload and tumor calcification. On the other hand, the released H2O2 can convert into more toxic reactive oxygen species (ROS) via exogenous stimulation and endogenous regulation, thereby making nano‐CaO2 a versatile tool in modern medicine, exhibiting its invaluable and irreplaceable medical value in tumor therapy. Hence, a comprehensive review of the recent advances in the nano‐CaO2 platform is imperative. This review provides an overview of the conventional synthesis strategies for nano‐CaO2. It elucidates the potential role of the nano‐CaO2 nanoplatforms in various tumor treatment strategies, including monotherapy and combination therapy, in detail. Given the remarkable outcomes achieved to date and the challenges that of future clinical translation, this work predicts the future research directions. This review will encourage further development of the metal oxide nanomedicine family, epitomized by nano‐CaO2.

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Peptide‐Conjugated Nano‐Drug Delivery System to Improve Synergistic Molecular Chemotherapy for Colon Carcinoma

Cited by 8 publications

References 49 publications

Drug-Carrying Capacity and Anticancer Effect of the Folic Acid- and Berberine-Loaded Silver Nanomaterial To Regulate the AKT-ERK Pathway in Breast Cancer

Drug-Carrying Capacity and Anticancer Effect of the Folic Acid- and Berberine-Loaded Silver Nanomaterial To Regulate the AKT-ERK Pathway in Breast Cancer

Eco-Friendly Formulation of Selenium Nanoparticles and Its Functional Characterization against Breast Cancer and Normal Cells

Composite Nanoplatforms Based on Nanocalcium Peroxide for Cancer Treatment: From Monotherapy to Combination Therapy

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