Peptide Biomaterials for Tissue Regeneration

Ross, Alex; Sauce-Guevara, Mildred A.; Alarcon, Emilio I.; Méndez‐Rojas, Miguel A.

doi:10.3389/fbioe.2022.893936

Cited by 7 publications

(9 citation statements)

References 110 publications

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“…Although biomaterials support healing processes, their modification with peptide sequences can improve antimicrobial, proangiogenic, and immunomodulatory properties. New peptides with biofunctional activities are being discovered . Thus, various scientific groups − employed genomics to identify new short peptides, indicating their immunomodulatory properties toward keratinocytes, periodontal ligament cells, or endothelial cells in the context of regeneration, cytokine secretion, cell apoptosis, or viability.…”

Section: Biomolecules Used For Bone Regenerationmentioning

confidence: 99%

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Bioactive Materials for Bone Regeneration: Biomolecules and Delivery Systems

Szwed-Georgiou

Płociński

Kupikowska-Stobba

et al. 2023

ACS Biomater. Sci. Eng.

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Novel tissue regeneration strategies are constantly being developed worldwide. Research on bone regeneration is noteworthy, as many promising new approaches have been documented with novel strategies currently under investigation. Innovative biomaterials that allow the coordinated and wellcontrolled repair of bone fractures and bone loss are being designed to reduce the need for autologous or allogeneic bone grafts eventually. The current engineering technologies permit the construction of synthetic, complex, biomimetic biomaterials with properties nearly as good as those of natural bone with good biocompatibility. To ensure that all these requirements meet, bioactive molecules are coupled to structural scaffolding constituents to form a final product with the desired physical, chemical, and biological properties. Bioactive molecules that have been used to promote bone regeneration include protein growth factors, peptides, amino acids, hormones, lipids, and flavonoids. Various strategies have been adapted to investigate the coupling of bioactive molecules with scaffolding materials to sustain activity and allow controlled release. The current manuscript is a thorough survey of the strategies that have been exploited for the delivery of biomolecules for bone regeneration purposes, from choosing the bioactive molecule to selecting the optimal strategy to synthesize the scaffold and assessing the advantages and disadvantages of various delivery strategies.

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Section: Biomolecules Used For Bone Regenerationmentioning

confidence: 99%

“…Also, peptides are frequently incorporated into biomaterials to improve the repairing of cardiovascular tissue. 37 Amino Acids. Amino acids are the building blocks of proteins.…”

Section: ■ Introductionmentioning

confidence: 99%

Bioactive Materials for Bone Regeneration: Biomolecules and Delivery Systems

Szwed-Georgiou

Płociński

Kupikowska-Stobba

et al. 2023

ACS Biomater. Sci. Eng.

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“…Additionally, such scaffolds provide structural support for newly formed tissues [ 10 , 11 ]. Cell colonization, migration, and differentiation, as well as tissue growth, can be supported by peptide-based materials, which often control the development of the tissue [ 12 ]. A peptide-based scaffold should comprise interconnected porosities, surface functional groups to allow cell interactions, and adequate mechanical properties.…”

Section: Introductionmentioning

confidence: 99%

“…A peptide-based scaffold should comprise interconnected porosities, surface functional groups to allow cell interactions, and adequate mechanical properties. The optimal scaffold should also be biodegradable or bioresorbable, nontoxic upon degradation, and easy to construct [ 12 ]. The tremendous advancements in this field in recent years emphasize its potential to revolutionize biomedical research.…”

Section: Introductionmentioning

confidence: 99%

Design of Functional RGD Peptide-Based Biomaterials for Tissue Engineering

et al. 2023

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Tissue engineering (TE) is a rapidly expanding field aimed at restoring or replacing damaged tissues. In spite of significant advancements, the implementation of TE technologies requires the development of novel, highly biocompatible three-dimensional tissue structures. In this regard, the use of peptide self-assembly is an effective method for developing various tissue structures and surface functionalities. Specifically, the arginine–glycine–aspartic acid (RGD) family of peptides is known to be the most prominent ligand for extracellular integrin receptors. Due to their specific expression patterns in various human tissues and their tight association with various pathophysiological conditions, RGD peptides are suitable targets for tissue regeneration and treatment as well as organ replacement. Therefore, RGD-based ligands have been widely used in biomedical research. This review article summarizes the progress made in the application of RGD for tissue and organ development. Furthermore, we examine the effect of RGD peptide structure and sequence on the efficacy of TE in clinical and preclinical studies. Additionally, we outline the recent advancement in the use of RGD functionalized biomaterials for the regeneration of various tissues, including corneal repair, artificial neovascularization, and bone TE.

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“…The complex binding of copper ions with peptide structures has promoted collagen production, increased vascular growth, and antioxidant capacity, and stimulated glucosaminoglycan production, supporting the skin’s self-repair processes [ 3 ]. As an activator of tissue remodeling, bound copper can also promote the growth, division, and differentiation of nerve cells, immune-related cells, and glomerular cells and stimulate the production of epidermal stem cell proliferation markers and integrin [ 4 ].…”

Section: Introductionmentioning

confidence: 99%

Metal–Peptide Complexes with Antimicrobial Potential for Cotton Fiber Protection

Georgieva

Todorov

Staneva

et al. 2023

JFB

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A study of the formation of copper (II) complexes with hemorphin peptide motifs in alkalic water solutions is presented. The effect of the peptide ligand on the complexing properties of the Cu (II) ion was quantified by giving the stoichiometry and stability of the complex compounds in the medium in which they are formed using voltammetric (cyclic) and spectral (UV-Vis and fluorimetric) analytical techniques. The resulting complexes were examined via IR spectroscopy to detect M-N and M-O oscillations and using the EPR approach in solution and in the solid phase to view the coordination and ligand binding regime. The possibility of the synergistic action of copper ions in the antivirus protection processes of cotton fibers coated in the same solvent with the newly obtained complex compounds was also investigated. One of the advantages is the formation of the complexes in an environment where the immobilization takes place, which contributes to increasing the efficiency of the process. The obtained results may serve as an aid for future more detailed biological studies of structure–activity relationships (SARs).

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Peptide Biomaterials for Tissue Regeneration

Cited by 7 publications

References 110 publications

Bioactive Materials for Bone Regeneration: Biomolecules and Delivery Systems

Bioactive Materials for Bone Regeneration: Biomolecules and Delivery Systems

Design of Functional RGD Peptide-Based Biomaterials for Tissue Engineering

Metal–Peptide Complexes with Antimicrobial Potential for Cotton Fiber Protection

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