Peptide-Based Materials for Cartilage Tissue Regeneration

Haştar, Nurcan; Arslan, Elif Acar; Güler, Mustafa O.; Tekinay, Ayşe B.

doi:10.1007/978-3-319-66095-0_7

Cited by 15 publications

(8 citation statements)

References 51 publications

(51 reference statements)

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“…Due to their diversity, peptides are thought as one of the most promising molecules in cartilage regeneration because they can serve as components of permeable scaffolds or bio-functional factors [ 120 ]. For instance, Link protein N-terminal peptide (LPP) in ECM of cartilage was shown to stimulate the proliferation of cartilage stem/progenitor cells (CSPCs) [ 121 ].…”

Section: Current State-of-art Of Hydrogels Designed For Cartilage Regmentioning

confidence: 99%

Advanced hydrogels for the repair of cartilage defects and regeneration

Wei

Yao

et al. 2021

Bioactive Materials

241

176

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Cartilage defects are one of the most common symptoms of osteoarthritis (OA), a degenerative disease that affects millions of people world-wide and places a significant socio-economic burden on society. Hydrogels, which are a class of biomaterials that are elastic, and display smooth surfaces while exhibiting high water content, are promising candidates for cartilage regeneration. In recent years, various kinds of hydrogels have been developed and applied for the repair of cartilage defects in vitro or in vivo , some of which are hopeful to enter clinical trials. In this review, recent research findings and developments of hydrogels for cartilage defects repair are summarized. We discuss the principle of cartilage regeneration, and outline the requirements that have to be fulfilled for the deployment of hydrogels for medical applications. We also highlight the development of advanced hydrogels with tailored properties for different kinds of cartilage defects to meet the requirements of cartilage tissue engineering and precision medicine.

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Section: Current State-of-art Of Hydrogels Designed For Cartilage Regmentioning

confidence: 99%

Advanced hydrogels for the repair of cartilage defects and regeneration

Wei

Yao

et al. 2021

Bioactive Materials

241

176

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“…In addition, there are a group of peptides that can self-assemble into hydrogels for tissue engineering. These peptides include RADA16 (AcN-(RADA) 4 -COHN 2 ), KLD-12 (AcN-KLDLKLDLKLDL-CNH 2 ), PS-b-PEO-Ada, palmitoyl-V 3 A 3 K 3 –Am and HSNGLPL [ 37 , 92 , 93 ]. The self-assembled peptides gelate through noncovalent self-assembly mechanisms, and these noncovalent interactions are useful for the attachment of bioactive groups that replicate the functions of proteins [ 37 ].…”

Section: Bioactive Peptide To Promote Chondrogenesismentioning

confidence: 99%

“…These peptides include RADA16 (AcN-(RADA) 4 -COHN 2 ), KLD-12 (AcN-KLDLKLDLKLDL-CNH 2 ), PS-b-PEO-Ada, palmitoyl-V 3 A 3 K 3 –Am and HSNGLPL [ 37 , 92 , 93 ]. The self-assembled peptides gelate through noncovalent self-assembly mechanisms, and these noncovalent interactions are useful for the attachment of bioactive groups that replicate the functions of proteins [ 37 ]. The self-assembling peptides mainly function as scaffolds and have been reviewed elsewhere [ 19 ].…”

Section: Bioactive Peptide To Promote Chondrogenesismentioning

confidence: 99%

“…Peptides also show promising potential in the field of cartilage tissue engineering [ 37 ]. Through mimicking the actions of chondrogenesis-related ligands, cell-cell junction molecules and ECM compositions, a large variety of peptides have been designed to trigger desired cellular signaling pathways [ [38] , [39] , [40] , [41] , [42] , [43] ].…”

Section: Introductionmentioning

confidence: 99%

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Chondroinductive/chondroconductive peptides and their-functionalized biomaterials for cartilage tissue engineering

Zhu

Zhong

Cao

et al. 2022

Bioactive Materials

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The repair of articular cartilage defects is still challenging in the fields of orthopedics and maxillofacial surgery due to the avascular structure of articular cartilage and the limited regenerative capacity of mature chondrocytes. To provide viable treatment options, tremendous efforts have been made to develop various chondrogenically-functionalized biomaterials for cartilage tissue engineering. Peptides that are derived from and mimic the functions of chondroconductive cartilage extracellular matrix and chondroinductive growth factors, represent a unique group of bioactive agents for chondrogenic functionalization. Since they can be chemically synthesized, peptides bear better reproducibility, more stable efficacy, higher modifiability and yielding efficiency in comparison with naturally derived biomaterials and recombinant growth factors. In this review, we summarize the current knowledge in the designs of the chondroinductive/chondroconductive peptides, the underlying molecular mechanisms and their-functionalized biomaterials for cartilage tissue engineering. We also systematically compare their in-vitro and in-vivo efficacies in inducing chondrogenesis. Our vision is to stimulate the development of novel peptides and their-functionalized biomaterials for cartilage tissue engineering.

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“…In the specific context of cartilage repair, SAPs are interesting materials since the self‐assembling process results in highly hydrated material (more than 90% water content) and native cartilage is highly hydrated (80% water content), a feature offering the tissue its “shock absorber” capabilities. SAPs also offer the advantage of being injectable into nonuniform defects, thanks to their malleability and it is highly conceivable that they can be used to infiltrate and coat porous scaffolds intended to serve as implants. Moreover, SAPs have been shown to sustain or allow recovery of the chondrogenic phenotype with expression of cartilage‐specific matrix proteins when they are combined with rabbit, bovine, and human chondrocytes.…”

Section: Introductionmentioning

confidence: 99%

Combination of bioactive factors and IEIK13 self‐assembling peptide hydrogel promotes cartilage matrix production by human nasal chondrocytes

Dufour

Buffier²,

Vertu-Ciolino

et al. 2019

J Biomedical Materials Res

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Nasal reconstruction remains a challenge for every reconstructive surgeon. Alloplastic implants are proposed to repair nasal cartilaginous defects but they are often associated with high rates of extrusion and infection and poor biocompatibility. In this context, a porous polymeric scaffold filled with an autologous cartilage gel would be advantageous. In this study, we evaluated the capacity of IEIK13 self‐assembling peptide (SAP) to serve as support to form such cartilage gel. Human nasal chondrocytes (HNC) were first amplified with FGF‐2 and insulin, and then redifferentiated in IEIK13 with BMP‐2, insulin, and T3 (BIT). Our results demonstrate that IEIK13 fosters HNC growth and survival. HNC phenotype was assessed by RT‐PCR analysis and neo‐synthesized extracellular matrix was characterized by western blotting and immunohistochemistry analysis. BIT‐treated cells embedded in IEIK13 displayed round morphology and expressed cartilage‐specific markers such as type II and type IX collagens and aggrecan. In addition, we did not detect significant production of type I and type X collagens and gene products of dedifferentiated and hypertrophic chondrocytes that are unwanted in hyaline cartilage. The whole of these results indicates that the SAP IEIK13 represents a suitable support for hydrogel‐based tissue engineering of nasal cartilage. © 2018 Wiley Periodicals, Inc. J Biomed Mater Res Part A: 107A: 893–903, 2019.

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Peptide-Based Materials for Cartilage Tissue Regeneration

Cited by 15 publications

References 51 publications

Advanced hydrogels for the repair of cartilage defects and regeneration

Advanced hydrogels for the repair of cartilage defects and regeneration

Chondroinductive/chondroconductive peptides and their-functionalized biomaterials for cartilage tissue engineering

Combination of bioactive factors and IEIK13 self‐assembling peptide hydrogel promotes cartilage matrix production by human nasal chondrocytes

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