Peptide-Assisted Synthesis of Gold Nanoparticles and Their Self-Assembly

Bhattacharjee, Rama Ranjan; Das, Apurba K.; Haldar, Debasish; Si, Satyabrata; Banerjee, Arindam; Mandal, Tarun K.

doi:10.1166/jnn.2005.166

Cited by 78 publications

(80 citation statements)

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“…[10][11][12][13][14][15][16][17][18][19][20][21][22][23][24][25] Recently, there has been increasing interest in the development of biological synthesis for Au NPs because of the need for an environmentally acceptable solvent system and eco-friendly reducing and capping agents. [26][27][28] Xie et al first demonstrated the synthesis of highly fluorescent protein-stabilized Au NCs using a bovine-serum alubumin (BSA)-templated method. 22 The as-prepared Au NCs consisted of 25 gold atoms (Au25) with a red emission at 640 nm.…”

Section: Introductionmentioning

confidence: 99%

Trypsin-Stabilized Fluorescent Gold Nanocluster for Sensitive and Selective Hg2+ Detection

et al. 2011

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We report on trypsin-stabilized fluorescent gold nanoclusters (Au NCs) for the sensitive and selective detection of Hg 2+ ions. The Au NCs have an average size of 1 nm and show a red emission at 645 nm. The photostable properties of the trypsin-stabilized Au NCs were examined, and their photochemical stability was found to be similar to that of CdSe quantum dots. The fluorescence was particularly quenched by Hg 2+ , and therefore the Au NCs can be used as fluorescent sensors for sensitive and selective Hg 2+ detection to a detection limit of 50 ± 10 nM and the quantitative detection of Hg 2+ in wide and low concentration range of 50 -600 nM.

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Section: Introductionmentioning

confidence: 99%

Trypsin-Stabilized Fluorescent Gold Nanocluster for Sensitive and Selective Hg2+ Detection

et al. 2011

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“…[10] In our previous work we have reported the formation of GNPs and their self-assembly using a tyrosine-containing short peptide. [11] To the best of our knowledge, nobody has reported the role of tyrosine in the formation of metal nanoparticles in detail. It has been reported that tyrosine has an important function in electron transfer in the photosystem II (PSII), a vital process in nature leading to a neutral tyrosyl Abstract: Synthetic oligopeptides containing redox-active tyrosine residues have been employed to prepare gold and silver nanoparticles.…”

Section: Introductionmentioning

confidence: 99%

A Mechanistic and Kinetic Study of the Formation of Metal Nanoparticles by Using Synthetic Tyrosine‐Based Oligopeptides

Bhattacharjee

Banerjee

et al. 2006

Chemistry A European J

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Synthetic oligopeptides containing redox-active tyrosine residues have been employed to prepare gold and silver nanoparticles. In this reduction process an electron from the tyrosinate ion of the peptide is transferred to the metal ion at basic pH through the formation of a tyrosyl radical, which is eventually converted to its dityrosine form during the reaction. This reaction mechanism was confirmed from UV-visible, fluorescence, and EPR spectroscopy and was found to be pH-dependent. Transmission electron microscopy measurement shows that the average size and the monodispersity of gold nanoparticles increase as the number of tyrosine residues in the peptide increases. The kinetic study, based on spectrophotometric measurements of the surface plasmon resonance optical property, shows that the rate of formation of gold nanoparticles was much faster at higher pH than at lower pH and was also dependent on the number of tyrosine residues present in the peptide. The dityrosine form of the peptide was found to retain reducing properties like those of tyrosine in basic medium.

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“…In 2005, Bhattacharjee et al 18 reported an approach to prepare colloidal GNP-tripeptides through an in situ tyrosine reduction technique. The designed tripeptide sequence was H2N-Leu-Aib-Tyr-OMe (Aib is 2-aminoisobutyric acid, or 2-methylalanine); tyrosine was included at the C-terminus to act as an electron-transfer agent.…”

Section: Chemical Reductionmentioning

confidence: 99%

Peptide-functionalized gold nanoparticles: versatile biomaterials for diagnostic and therapeutic applications

2017

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Colloidal gold solutions have been used for centuries in a wide variety of applications including staining glass and in the colouring of ceramics. More recently, gold nanoparticles (GNPs) have been studied extensively due to their interesting size-dependent electronic and optical properties. GNPs can be functionalized easily with biomolecules that contain thiols, amines, or even phosphine moieties. For example, the reaction of thiol-containing peptides with GNPs has been used extensively to prepare novel hybrid materials for biomedical applications. A range of different types of peptides can be used to access biomaterials that are designed to perform a specific role such as cancer cell targeting. In addition, specific peptide sequences that are responsive to external stimuli (e.g. temperature or pH) can be used to stabilise / destabilise the aggregation of colloidal GNPs. Such systems have exciting potential applications in the field of colorimetric sensing (including bio-sensing) and in targeted drug delivery platforms. In this review, we will give an overview of the current methods used for preparing peptide functionalized GNPs, and we will discuss their key properties outlining the 2 various applications of this class of biomaterial. In particular, the potential applications of peptide functionalized GNPs in areas of sensing and targeted drug delivery will be discussed.

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Peptide-Assisted Synthesis of Gold Nanoparticles and Their Self-Assembly

Cited by 78 publications

References 0 publications

Trypsin-Stabilized Fluorescent Gold Nanocluster for Sensitive and Selective Hg2+ Detection

Trypsin-Stabilized Fluorescent Gold Nanocluster for Sensitive and Selective Hg2+ Detection

A Mechanistic and Kinetic Study of the Formation of Metal Nanoparticles by Using Synthetic Tyrosine‐Based Oligopeptides

Peptide-functionalized gold nanoparticles: versatile biomaterials for diagnostic and therapeutic applications

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