“…There seems little doubt that patients with rheumatoid arthritis requiring therapy with steroids and aspirin have a higher incidence of gastric ulcer (Kern, et al, 1957;Krammerer et al, 1958;Gedda and Moritz, 1959;Bowen et al, 1960;Taylor et al, 1968). While corticosteroids increase gastric acid secretion in dogs they do not alter ionic permeability (Cooke et al, 1966;Cooke, 1967;Chung, et al 1970).…”