Back Diffusion of Hydrogen Ions across Gastric Mucosa of Patients with Gastric Ulcer and Rheumatoid Arthritis

Ivey, Kevin J.; Clifton, James

doi:10.1136/bmj.1.5896.16

Cited by 19 publications

(7 citation statements)

References 15 publications

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“…Similar reversal, from net gastric secretion in response to an acid load to net loss from the lumen has been noted after intravenous atropine (Ivey & Clifton, 1974), although the magnitude of the reversal is greater with metiamide, presumably because metiamide inhibits gastric secretion of acid more than atropine under these experimental circumstances and, by inhibiting the gastric secretion of acid, 'uncovers' intragastric losses of acid.…”

Section: Efect Of Metiamide On the Secretory Response To Instilled Somentioning

confidence: 57%

Effects of Metiamide on the Human Stomach

Þjóðleifsson

Wormsley

1975

Clinical Science

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1. The effect of metiamide on gastric acidity in man has been studied. Solutions of hydrochloric acid or glucose were instilled into the stomach and the subsequent rates of gastric secretion and emptying, and the disappearance of acid within the stomach, were measured. 2. Metiamide inhibited the gastric secretory response to the instilled acid and glucose solutions but did not change the overall pattern of emptying of the instilled solutions. 3. During administration of metiamide, there was a net loss of acid from within the gastric lumen. The rate of disappearance of acid from the instilled acid solution was small and not sufficient in magnitude to account for the metiamide-evoked decrease in the concentration of acid secreted in response to pentagastrin. 4. We conclude that metiamide does not inhibit gastric secretion by altering the 'barrier' function of the gastric mucosa.

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Section: Efect Of Metiamide On the Secretory Response To Instilled Somentioning

confidence: 57%

Effects of Metiamide on the Human Stomach

Þjóðleifsson

Wormsley

1975

Clinical Science

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“…Davenport (1965) postulated that the abnormal gastric mucosa of patients with gastric ulcers allowed excessive reabsorption of secreted hydrogen ions, thereby causing apparent hyposecretion. Permeability studies in gastric ulcer patients have provided some evidence in favour of this hypothesis (Chapman et al, 1968;Chapman et al, 1972;Ivey and Clifton 1974). However, problems with recovery of instilled solutions, neutralisation, secretion, and gastric emptying make such studies difficult in man, and the results are sometimes inaccurate.…”

mentioning

confidence: 99%

Potential difference across the normal and the abnormal gastric mucosa in man.

Hossenbocus¹,

Fitzpatrick²,

Colin‐Jones³

1976

Gut

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SUMMARY The mucosal potential difference in the body of the stomach was measured in 18 patients with gastric ulcers, five with gastritis, and three with pernicious anaemia. The results were compared with those of 12 normal volunteers. Significantly lower than normal levels were found in the groups of patients with gastric ulcers and gastritis. The patients with pernicious anaemia had even lower potential differences. In an additional 25 subjects, measurements were made in the duodenal bulb and at five sites in the stomach under direct vision at endoscopy. Biopsies were taken from each site for histology. Subjects with gastritis at the high lesser curve had a significantly lower potential difference at that site than those without gastritis. In the latter group, the potential difference at the high lesser curve was as low as in the antrum, and invariably lower than at the high greater curve.

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“…Study II Ionic fluxes Our methodology has been described in detail elsewhere (Ivey and Clifton, 1971a;Ivey et al, 1972a;Ivey and Clifton, 1974).…”

Section: Experimental Technique Laboratory Measurements and Calculamentioning

confidence: 99%

“…Exactly 15 minutes later gastric contents were aspirated as fully as possible and the residual volume recovered by rinsing with wash solution. Net ion flux = amount of ion aspirated + amount of ion emptied -amount of ion initially present (Ivey and Clifton, 1974). A positive flux indicates a net addition of ions to the lumen.…”

Section: Experimental Technique Laboratory Measurements and Calculamentioning

confidence: 99%

Effect of paracetamol (acetaminophen) on gastric ionic fluxes and potential difference in man.

Ivey¹,

Settree²

1976

Gut

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SUMMARY Paracetamol has replaced aspirin as the analgesic of choice in many situations. The major reason is the damaging effect of aspirin on gastric mucosa. Alterations in gastric ionic fluxes and potential difference provide measures of aspirin-induced structural damage. We studied the effect of large doses of paracetamol (acetaminophen 2-0 g) on gastric ionic fluxes in man. In addition, the effect of 2-0 g paracetamol on gastric potential difference was compared with that of 600 mg aspirin. (Goulston and Skyring, 1964). Vickers in 1967 found a 17% incidence of visible gastroscopic lesions after aspirin compared with 0% after paracetamol. This study, however, seriously underestimated the incidence of aspirin-induced damage as measured by other techniques (Goulston and Skyring, 1964) including microscopic examination of gastric biopsies (Ivey et al., 1975a), which indicated damage in 100% of subjects.Aspirin has been well documented to damage

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Back Diffusion of Hydrogen Ions across Gastric Mucosa of Patients with Gastric Ulcer and Rheumatoid Arthritis

Cited by 19 publications

References 15 publications

Effects of Metiamide on the Human Stomach

Effects of Metiamide on the Human Stomach

Potential difference across the normal and the abnormal gastric mucosa in man.

Effect of paracetamol (acetaminophen) on gastric ionic fluxes and potential difference in man.

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