Peptic Ulcer Disease

Dunlap, Jayne Jennings; Patterson, Sheila

doi:10.1097/sga.0000000000000478

Cited by 41 publications

(24 citation statements)

References 2 publications

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“…The incidence of peptic ulcer disease (PUD) increases as patients get older, with an estimated prevalence of about 10% in the general population [ 1 , 2 ]. Peptic ulcers are described as defects or injuries in the gastroduodenal mucosa caused by peptic acid [ 3 ]. This ulceration is associated with stomach pain and often leads to gastrointestinal bleeding.…”

Section: Introductionmentioning

confidence: 99%

RETRACTED: Optimized Ellagic Acid–Ca Pectinate Floating Beads for Gastroprotection against Indomethacin-Induced Gastric Injury in Rats

et al. 2020

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A peptic ulcer is an alimentary tract injury that leads to a mucosal defect reaching the submucosa. This work aimed to optimize and maximize ellagic acid (EA) loading in Ca pectinate floating beads to maximize the release for 24 h. Three factors were selected: Ca pectinate concentration (X1, 1–3 w/v %), EA concentration (X2, 1–3 w/v %) and the dropping time (X3, 10–30 min). The factorial design proposed eight formulations. The optimized EA–Ca pectinate formulation was evaluated for the gastric ulcer index and the oxidative stress parameter determination of gastric mucosa. The results indicated that the optimum EA–Ca pectinate formula significantly improved the gastric ulcer index in comparison with raw EA. The protective effect of the optimized EA–Ca pectinate formula was further indicated by the histopathological features of the stomach. The results of the study indicate that an EA formulation in the form of Ca pectinate beads would be effective for protection against gastric ulcers because of Nonsteroidal anti-inflammatory drugs (NSAID) administration.

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Section: Introductionmentioning

confidence: 99%

RETRACTED: Optimized Ellagic Acid–Ca Pectinate Floating Beads for Gastroprotection against Indomethacin-Induced Gastric Injury in Rats

et al. 2020

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“…Aspirin, NSAIDs, and H. pylori are independent risk factors for PUD and its complications (54)(55)(56). The incidence of PUD increases with age, with most ulcers occurring between the ages of 25 and 64 (57). The most common and serious complication of PUD is bleeding, and people aged >60 years are at the highest risk of suffering from it (58).…”

Section: Peptic Ulcer Diseasementioning

confidence: 99%

Helicobacter pylori Infection in Geriatric Patients: Current Situation and Treatment Regimens

et al. 2021

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Helicobacter pylori (H. pylori) has so far infected more than half the global population. It is the most important and controllable risk factor for gastric cancer. The elderly, who are at a higher incidence of the infection, are also commonly found to develop antibiotic resistance. The symptoms, diagnosis, clinical features (of gastric or extra-digestive diseases), and treatment of H. pylori infection in the elderly, are different from that in the non-elderly. Health conditions, including comorbidities and combined medication have limited the use of regular therapies in elderly patients. However, they can still benefit from eradication therapy, thus preventing gastric mucosal lesions and gastric cancer. In addition, new approaches, such as dual therapy and complementary therapy, have the potential to treat older patients with H. pylori infection.

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“…Invasive factors including hydrochloric acid, pepsin, smoking and drinking, helicobacter pylori infection, non-steroidal anti-inflammatory drugs, certain dietary habits, and psychological stress can cause gastrointestinal mucosal lesions, which in severe cases can lead to ulcers [ 5 , 6 ]. Alcohol consumption worldwide increases as people’s material well-being increases, and the number of alcohol-related gastrointestinal diseases increases year by year [ 7 ].…”

Section: Introductionmentioning

confidence: 99%

Protective Effects of Small-Molecule Oligopeptides Isolated from Tilapia Fish Scale on Ethanol-Induced Gastroduodenal Injury in Rats

Liu

et al. 2021

Nutrients

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Peptic ulcer has a serious impact on people’s health around the world, and traditional medicines can cause adverse reactions. This study investigated the protective effects of tilapia collagen oligopeptides (TCOPs) on gastroduodenal injury. Seventy-two specific pathogen-free (SPF) male Sprague Dawley (SD) rats were randomly divided into six groups according to body weight: normal control group, ethanol group, whey protein group (500 mg/kg BW), and three TCOPs dose groups (250, 500, 1000 mg/kg BW). After intragastric administration for 30 days, the acute gastroduodenal injury was induced by anhydrous ethanol (5 mL/kg, intragastrically) in all groups except the normal control group. Biomarkers in gastric and duodenal tissue and serum were measured. Furthermore, western blot was used to detect the expression of apoptosis-related proteins. The results showed that the administration with TCOPs significantly reduced gastric and duodenal ulcer index, increased gastric juice pH, superoxide dismutase (SOD), catalase (CAT), and glutathione peroxidase (GSH-Px) activities, along with the reduction of malondialdehyde (MDA) contents. TCOPs decreased tumor Necrosis Factor-α (TNF-α), interleukin-1β (IL-1β), and myeloperoxidase (MPO) levels, while interleukin– 10 (IL-10) levels were increased. Furthermore, pepsinogens 1 (PG1), pepsinogens 2 (PG2), gastrin (GAS), and the pepsinogen ratio (PGR) were decreased, the prostaglandin E2 (PGE2) and NO contents were increased after TCOPs intervention. Moreover, TCOPs up-regulated the expression of Bcl-2 and inhibited the expression of Bax and Caspase-3. In conclusion, TCOPs have protective effects on ethanol-induced gastroduodenal injury through gastrointestinal mucosal microcirculation promotion, antioxidation, anti-inflammation, and anti-apoptosis mechanisms.

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Peptic Ulcer Disease

Cited by 41 publications

References 2 publications

RETRACTED: Optimized Ellagic Acid–Ca Pectinate Floating Beads for Gastroprotection against Indomethacin-Induced Gastric Injury in Rats

RETRACTED: Optimized Ellagic Acid–Ca Pectinate Floating Beads for Gastroprotection against Indomethacin-Induced Gastric Injury in Rats

Helicobacter pylori Infection in Geriatric Patients: Current Situation and Treatment Regimens

Protective Effects of Small-Molecule Oligopeptides Isolated from Tilapia Fish Scale on Ethanol-Induced Gastroduodenal Injury in Rats

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