Consider the range of social behaviours we engage in every day. In each case, there are a multitude of unknowns, reflecting the many sources of uncertainty inherent to social inference. We describe how uncertainty manifests in social environments (the thoughts and intentions of others are largely hidden, making it difficult to predict a person's behaviour) and why people are motivated to reduce the aversive feelings generated by uncertainty. We propose a three-part model whereby social uncertainty is initially reduced through automatic modes of inference (such as impression formation) before more control-demanding modes of inference (such as perspective-taking) are deployed to narrow one's predictions even more. Finally, social uncertainty is attenuated further through learning processes that update these predictions based on new information. Our framework integrates research across fields to offer an account of the mechanisms motivating social cognition and action, laying the groundwork for future experiments that can illuminate the impact of uncertainty on social cognition. We are often faced with decisions that require us to consider our effect on others, as well as their effect on us. To date, research exploring social decision-making has focused on the vital role of reward and punishment in guiding choice. A large body of work now demonstrates that these decisions are driven by the same reward-related computations and neural circuitry as non-social decisions 1,2. However, there is another critical-and equally potent-motivator of social behaviour: the desire to reduce uncertainty 3-6. Interacting with others is one of the most inherently uncertain acts humans embark on. There are a multitude of unknowns, whether it is choosing how to express ourselves 7 , who to confide in 8 , how reliable an individual is 9,10 or whether to engage in risky behaviour with our peers 11,12. The information we bring to bear on each of these decisions-from the expected trustworthiness or competence of others 8,13 to their anticipated reactions to an offcolour joke-relies on uncertain estimates 14. It is therefore critical to our productivity, wellbeing and ultimately our survival as social beings to constantly estimate these uncertainties and find ways to reduce them 15 .