Pentraxin3 as a new indicator of cardiovascular-related death in patients with advanced chronic kidney disease?

Krzanowski, Marcin; Krzanowska, Katarzyna; Gajda, Mariusz; Dumnicka, Paulina; Dziewierz, Artur; Woziwodzka, Karolina; Litwin, Jan A.; Sułowicz, Władysław

doi:10.20452/pamw.3944

Cited by 18 publications

(21 citation statements)

References 19 publications

(27 reference statements)

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“…[21][22][23] Proinflammatory cytokines and metabolic abnormalities associated with systemic inflammation are considered one of the principal mechanisms leading to endothelial dysfunction. 24 In the present study, SDF1α, sTNFRII, and MMP -2 were independent predictors of an increased ADMA level. There are risk factors, and PTX3 as an acute -phase reactant synthesized locally at the site of inflammation.…”

Section: Discussionsupporting

confidence: 56%

Asymmetric dimethylarginine represents a precious risk indicator for radial artery calcification in patients with advanced kidney disease

Krzanowski¹,

Krzanowska²,

Gajda³

et al. 2018

Polish Archives of Internal Medicine

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INTRODUCTION Medial arterial calcification is common in patients with chronic kidney disease (CKD) and is considered a risk factor for morbidity and mortality. OBJECTIVES We aimed to evaluate the correlation between asymmetric dimethylarginine (ADMA) levels, radial artery calcification, and common carotid artery intima-media thickness (CCA‑IMT). PATIENTS AND METHODS The study included 51 patients with CKD, in whom an arteriovenous fistula for hemodialysis access was created to collect radial artery samples for a histological examination, and 33 healthy volunteers, in whom the reference concentrations of ADMA were assessed. The concentrations of creatinine, albumin, calcium, phosphate, fibroblast growth factor 23, osteoprotegerin (OPG), osteopontin (OPN), osteocalcin, secreted protein acidic and rich in cysteine, interleukin 6, interleukin 18, pentraxin 3, stromal cell‑derived factor 1α (SDF1α), thrombomodulin, soluble tumor necrosis factor receptor II (sTNFRII), and matrix metalloproteinase 2 (MMP‑2) were determined. Radial artery fragments were stained for calcifications using alizarin red. The CCA‑IMT was assessed by ultrasonography. RESULTS Patients with CKD had higher ADMA levels than controls. Patients with ADMA levels above the median were older, had higher levels of phosphate, fibroblast growth factor 23, OPG, OPN, PTX3, sTNFRII, MMP‑2, thrombomodulin, and they had more atherosclerotic plaques in the carotid artery. In multiple regression, log‑transformed (log)sTNFRII, MMP‑2, and SDF1α levels were independent predictors of log(ADMA). Patients with calcifications had higher ADMA levels. A similar correlation was observed between SDF1α and alizarin red staining grades 1 to 3. In logistic regression, ADMA levels positively predicted the presence of calcifications independently of age, hemodialysis status, Framingham risk score, and PTX3. CONCLUSIONS Circulating ADMA levels indicate medial arterial calcification in patients with CKD.

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Section: Discussionsupporting

confidence: 56%

Asymmetric dimethylarginine represents a precious risk indicator for radial artery calcification in patients with advanced kidney disease

Krzanowski¹,

Krzanowska²,

Gajda³

et al. 2018

Polish Archives of Internal Medicine

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“…PTX3, a marker of inflammation, is independently associated with the risk of vascular events. [12][13][14] There are data indicating that PTX3 also has anti -inflammatory and cardioprotective properties. 15 Plasma PTX3 level is, according to some data, a marker for nonalcoholic steatohepatitis and severity of liver fibrosis.…”

Section: Resultsmentioning

confidence: 99%

Serum pentraxin 3 concentration in patients with type 2 diabetes mellitus and non-alcoholic fatty liver disease

Trojak¹,

Waluś-Miarka²,

Kapusta³

et al. 2019

Polish Archives of Internal Medicine

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INTRODUCTION Nonalcoholic fatty liver disease (NAFLD) is common in patients with type 2 diabetes (T2D). Pentraxin 3 (PTX3), a marker of inflammation, is a cardiovascular risk factor. OBJECTIVES We examined clinical and biochemical factors associated with serum PTX3 concentrations in patients with T2D with and without NAFLD. PATIENTS AND METHODS Serum material was obtained from 116 patients with T2D (mean age, 59.1 years), including 79 patients with NAFLD. RESULTS Median (interquartile range) PTX3 level was 4.264 (2.293) ng/ml in patients with and 3.773 (3.223) ng/ml in patients without NAFLD (P = 0.93). In the whole group, PTX3 level was associated with total cholesterol, low-density lipoprotein cholesterol (LDL-C), apolipoprotein (apo) B100, apo C3, triglyceride (TG) concentrations, and waist circumference after adjustment for age and gender. As indicated by partial regression coefficient b, increase of independent variable LDL-C by 1 mmol/l was associated with the rise of PTX3 by 1.2017 ng/ml, increase of apo B100 by 1 mg/dl with the rise of PTX3 by 1.0051 ng/ml, and increase of apo C3 by 1 µg/dl with the rise of PTX3 by 1.0012 ng/ml. In patients with T2D with NAFLD, total cholesterol, LDL-C, TG, apo C3, and apo B100 were associated with PTX3. Associations of PTX3 with apolipoproteins were observed only in the NAFLD group. CONCLUSIONS Reported associations of PTX3 level add new insight into possible mechanisms of its atherogenic actions.

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“…In total, 568 deaths were recorded. Most studies ( n = 6) reported both unadjusted and adjusted HRs [11-14, 17, 27]; 3 studies reported only adjusted HRs [15, 16, 26], and 1 study reported only unadjusted HRs [28].…”

Section: Resultsmentioning

confidence: 99%

Elevated Osteoprotegerin Concentration Predicts Increased Risk of Cardiovascular Mortality in Patients with Chronic Kidney Disease: A Systematic Review and Meta-Analysis

Huang

et al. 2020

Kidney Blood Press Res

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Introduction: Studies have shown inconsistent results regarding the association between osteoprotegerin (OPG) concentration and cardiovascular mortality in patients with chronic kidney disease (CKD). This systematic review and meta-analysis aims to investigate the association between OPG concentration and cardiovascular mortality in patients with CKD. Methods: Between January 1970 and February 2020, the PubMed, EMBASE, and Cochrane Library databases were searched for eligible studies investigating the association between OPG concentration and cardiovascular mortality in patients with CKD. Pooled hazard ratios (HRs) and the corresponding 95% confidence intervals (CIs) were calculated using random effects models. Results: In total, 10 studies comprising 2,120 patients (including 1,723 receiving dialysis) with CKD were included. The included studies were considered to be of fair to high quality. Patients in the highest OPG concentration group had a significantly higher risk of cardiovascular mortality (4 studies; adjusted HR, 2.05; 95% CI, 1.39-3.00) than patients in the low OPG concentra

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Pentraxin3 as a new indicator of cardiovascular-related death in patients with advanced chronic kidney disease?

Cited by 18 publications

References 19 publications

Asymmetric dimethylarginine represents a precious risk indicator for radial artery calcification in patients with advanced kidney disease

Asymmetric dimethylarginine represents a precious risk indicator for radial artery calcification in patients with advanced kidney disease

Serum pentraxin 3 concentration in patients with type 2 diabetes mellitus and non-alcoholic fatty liver disease

Elevated Osteoprotegerin Concentration Predicts Increased Risk of Cardiovascular Mortality in Patients with Chronic Kidney Disease: A Systematic Review and Meta-Analysis

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